Results 71 to 80 of about 19,900 (217)

Enhancing antitumour response to proteasome inhibitors with inhibitors of insulin‐degrading enzyme, a new molecular vulnerability in multiple myeloma

British Journal of Pharmacology, EarlyView.
Inhibitors of insulin‐degrading enzyme boost PI cytotoxicity through an increased sensitivity of proteasome to PI inhibitors, induction of ISR, DNA damage and Myc down‐regulation. They overcome PI resistance in vitro and induce tumour regression in vivo.
Laetitia Lesire, Rebecca Deprez‐Poulain, Damien Bosc, Florence Leroux, Valerie Landry, Sarah Ourabah, Morgane Tardy, Clara Maillard, Ronan Gealageas, Julie Dumont, Adrien Herledan, Sandrine Warenghem, Manon Cruette, Celine Lenglart, Alexandre Biela, Catherine Piveteau, Eva De Smedt, Catharina Muylaert, Wenguang Liang, Elvira Garcia De Paco, Elina Alaterre, Sara Ovejero, Nicolas Robert, Fabien Delahaye, Wei‐Jen Tang, Peter van Endert, Elke De Bruyne, Jérôme Moreaux, Benoit Deprez   +28 more
wiley   +1 more source

Synthesis and biological evaluation of norfloxacin – 1,2,3-triazole hybrids as antitumor, antibacterial, and antioxidant agents

Results in Chemistry
Six norfloxacin-1,2,3-triazole hybrids(7a-e) were synthesized via click reaction. Norfloxacin-1,2,3-triazole hybrids were screened for anti-cancer activity against different cancer cell lines DLD1, MCF-7, A549 and HDF.
Samir Al-Taweel, Yousef Al-Saraireh, Salah Al-Trawneh, Solhe Alshahateet, Rakan Al- Tarawneh, Wael Zereini, Omar Al-Qaralleh, Ahmed Al-sarayreh, Mohammad Salem Hareedy, Y.M. Abuhalaweh, Amer Hussien Tarawneh   +10 more
doaj   +1 more source

Recent Advances in Bioactive Flavonoid Hybrids Linked by 1,2,3-Triazole Ring Obtained by Click Chemistry

Molecules, 2021
As a result of the biological activities of natural flavonoids, several synthetic strategies aiming to obtain analogues with improved potency and/or pharmacokinetic profile have been developed.
Daniela Pereira, Madalena Pinto, Marta Correia-da-Silva, Honorina Cidade   +3 more
doaj   +1 more source

Antimicrobial and cytotoxic activities of 1,2,3-triazole-sucrose derivatives [PDF]

, 2015
A library of 1-(1′,2,3,3′,4,4′,6-hepta-O-acetyl-6′-deoxy-sucros-6′-yl)-1,2,3-triazoles have been investigated for their antibacterial, antifungal and cytotoxic activities.
Barros, M. Teresa, Calhelha, Ricardo C., Correia-da-Silva, Paula, Ferreira, Isabel C.F.R., Petrova, Krasimira T., Potewar, Taterao M., Soković, Marina, Ćirić, Ana   +7 more
core   +1 more source

Development of a Self‐Adjuvanting Influenza Peptide–Glycolipid Conjugate Inducing CD8+ T‐Cell Immunity

ChemBioChem, Volume 27, Issue 5, 13 March 2026.
The glycolipid‐peptide antigen complexes for self‐adjuvanting conjugates were successfully synthesized, and, with the HLA‐transgenic mice, the antigen‐specific CD8+ T cell expansion was exhibited. The results provide useful insights for the design and synthesis of vaccine conjugates using glycolipid antigen as an adjuvant.
Shunya Kikuchi, Hideki Ogura, Takanori Matsumaru, Satoshi Ishido, Yukari Fujimoto   +4 more
wiley   +1 more source

CuAAC-inspired synthesis of 1,2,3-triazole-bridged porphyrin conjugates: an overview

Beilstein Journal of Organic Chemistry, 2023
Among all the available approaches in organic synthesis, the “click chemistry” protocol is very common nowadays to covalently connect two diverse moieties in a single framework. Therefore, this review focuses on the synthesis and photophysical studies of
Dileep Kumar Singh
doaj   +1 more source

Synthesis and Characterization of 1,2,3- Triazole Derivatives from D-Mannitol

Tikrit Journal of Pure Science, 2023
This research included the use of azido D-Mannitol (3) to synthesize 1,2,3 triazole derivatives. Azido D – Mannitol  (3) itself used as an intermediate which was prepared from reaction of  1, 2:5, 6-Di-o-isopropylidene-3,4-di-p-tosyl-D-Mannitol (2) with
Ihmood Kh. Juber
doaj   +1 more source

Electroactive tetrathiafulvalene based pyridine-mono and -bis(1,2,3-triazoles) click ligands: synthesis, crystal structures and coordination chemistry [PDF]

, 2014
Electroactive ligands picoline-1,2,3-triazole-5-DM-TTF and lutidine-bis(1,2,3-triazole-5-DM-TTF) are synthesized by click chemistry following the ruthenium catalyzed azide–alkyne cycloaddition strategy.
N. Avarvari, T. Biet
core   +3 more sources

Synthesis of Ribosylated 1,2,3‐Triazole Derivatives.

ChemInform, 2003
AbstractFor Abstract see ChemInform Abstract in Full Text.
Zhong‐Xu Ren, Xiao‐Min Chen, Zhan‐Jiang Li, Zhi‐Tang Huang   +3 more
openaire   +1 more source

Sensitive Energetics from the N‐Amination of 4‐Nitro‐1,2,3‐Triazole

ChemistryOpen, 2020
Energetic N‐amino‐C‐nitro compounds 1‐amino‐4‐nitro‐1,2,3‐triazole and 2‐amino‐4‐nitro‐1,2,3‐triazole are characterized for the first time as energetic materials. These compounds were characterized chemically by nuclear magnetic resonance (NMR), Infrared
Dominique R. Wozniak, Benjamin Salfer, Dr. Matthias Zeller, Dr. Edward F. C. Byrd, Prof. Davin G. Piercey   +4 more
doaj   +1 more source