Results 1 to 10 of about 40,232 (213)

Differential Effects of the Oncogenic BRAF Inhibitor PLX4032 (Vemurafenib) and its Progenitor PLX4720 on ABCB1 Function [PDF]

Journal of Pharmacy & Pharmaceutical Sciences, 2014
PURPOSE: The clinically approved oncogenic BRAF inhibitor PLX4032 (vemurafenib) was shown to be a substrate of the ATP-binding cassette (ABC) transporter ABCB1. Here, we compared PLX4032 and its structurally closely related precursor compound PLX4720 for
Martin Michaelis, Florian Rothweiler, Thomas Nerreter, Marijke van Rikxoort, Mohsen Sharifi, Michael Wiese, Taravat Ghafourian, Jindrich Cinatl   +7 more
doaj   +2 more sources

ABCB1 polymorphism in clopidogrel-treated Montenegrin patients

Open Life Sciences, 2021
Clopidogrel is an antiplatelet drug that displays significant interindividual variability in treatment response. Its bioavailability depends on the function of P-glycoprotein (P-gp), which is coded by a highly polymorphic ABCB1 gene.
Mugosa Snezana, Todorovic Zoran, Cukic Jelena, Sahman-Zaimovic Majda, Djordjevic Natasa   +4 more
doaj   +4 more sources

H89 Reverses Multidrug Resistance in Colorectal Cancer by Inhibiting the ATPase Activity of ABCB1 [PDF]

Biomedicines
Background: Multidrug resistance (MDR) remains a major obstacle in cancer chemotherapy, and overexpression of ABCB1 plays a critical role in the pathogenesis of MDR.
Wei-Jing Liu, Yi-Yao Shan, Huan Wang, Yu-Meng Xiong, Le-Yao Shi, Xiao-Peng Song, Min Li, Ke He, Jia Huang, Zhi Shi   +9 more
doaj   +2 more sources

Liver Enzyme Abnormalities and Associated Risk Factors in HIV Patients on Efavirenz-Based HAART with or without Tuberculosis Co-Infection in Tanzania. [PDF]

, 2012
To investigate the timing, incidence, clinical presentation, pharmacokinetics and pharmacogenetic predictors for antiretroviral and anti-tuberculosis drug induced liver injury (DILI) in HIV patients with or without TB co-infection.
A Habtewold, A Kwara, A Patel, A Tostmann, A Tostmann, A Tostmann, A Turkova, AK Daly, AM Anderson, B Lopman, BS Kappelhoff, C Benichou, C Nyakutira, CJ Hoffmann, CJ Hoffmann, D Voora, DF Wares, E Aklillu, E Aklillu, E Lopez-Lopez, E Ngaimisi, E Ngaimisi, E Pukenyte, Eleni Aklillu, Eliford Ngaimisi, Eric Sandstrom, Ferdinand Mugusi, G Yimer, G Yimer, G Yimer, GJ Dore, GL Dean, JG Stine, JJ Saukkonen, JK Mukonzo, JR Ungo, Juergen Burhenne, K Cohen, Klaus-Dieter Riedel, Lars Lindquist, LK Shipton, M Fiegenbaum, M Nelson, MI Matee, Mohamed Janabi, Muhammad Bakari, N Abrescia, N Soleman, Omary Minzi, P Kuehl, P Ocama, Petros C. Karakousis, R Kalyesubula, R Singla, RA Mirghani, S Russmann, Sabina Mugusi, SC Figueroa, SF Mugusi, V Gounden, W Mankhatitham, Z Desta, ZS Lamar   +62 more
core   +16 more sources

Lack of Association between C1236T, G2677T/A and C3435T Variants of the ABCB1 Gene and Imatinib Response in Iranian Chronic Myeloid Leukemia Patients [PDF]

Journal of Sciences, Islamic Republic of Iran, 2021
Imatinib introduction caused to improve the clinical outcomes of chronic myeloid leukemia (CML) patients. Despite the significant effects of Imatinib, pharmacogenetic variables induced treatment resistant is also observed.
Maedeh Khosravi, Zahra Khalaj, Negar Nouri, Malihe Najaflu, Valiollah Mehrzad, Mohammad Forat-Yazdi, Fariborz Mokarian, Mansour Salehi   +7 more
doaj   +1 more source

Minimally invasive differential diagnosis of melanocytic intraocular neoplasms

Российский офтальмологический журнал, 2023
Purpose: to analyze the mutation frequency of the GNAQ/GNA11 gene in circulating tumor DNA and genotypes of the polymorphic marker C3435T of the ABCB1 gene in a large sample of patients with intraocular melanocytic neoplasms (IMN).Material and methods ...
A. Yu. Tsygankov, S. V. Saakyan, E. B. Myakoshina, A. M. Burdennyi, V. I. Loginov   +4 more
doaj   +1 more source

The influence of BCL2, BAX, and ABCB1 gene expression on prognosis of adult de novo acute myeloid leukemia with normal karyotype patients

Radiology and Oncology, 2023
Deregulation of the apoptotic process underlies the pathogenesis of many cancers, including leukemia, but is also very important for the success of chemotherapy treatment.
Pravdic Zlatko, Vukovic Nada Suvajdzic, Gasic Vladimir, Marjanovic Irena, Karan-Djurasevic Teodora, Pavlovic Sonja, Tosic Natasa   +6 more
doaj   +1 more source

Polyoxypregnanes as safe, potent, and specific ABCB1-inhibitory pro-drugs to overcome multidrug resistance in cancer chemotherapy in vitro and in vivo

Acta Pharmaceutica Sinica B, 2021
Multidrug resistance (MDR) mediated by ATP binding cassette subfamily B member 1 (ABCB1) is significantly hindering effective cancer chemotherapy. However, currently, no ABCB1-inhibitory drugs have been approved to treat MDR cancer clinically, mainly due
Xu Wu, Chun Yin, Jiang Ma, Stella Chai, Chunyuan Zhang, Sheng Yao, Onat Kadioglu, Thomas Efferth, Yang Ye, Kenneth Kin-Wah To, Ge Lin   +10 more
doaj   +1 more source

PBK/TOPK inhibitor OTS964 resistance is mediated by ABCB1-dependent transport function in cancer: in vitro and in vivo study

Molecular Cancer, 2022
Highlights ABCB1 overexpression significantly desensitized both drug-selected and gene-transfected cells, which overexpress ABCB1, to OTS964 and that this drug resistance can be antagonized by verapamil, a known ABCB1 inhibitor.
Yuqi Yang, Qiu-Xu Teng, Zhuo-Xun Wu, Jing-Quan Wang, Zi-Ning Lei, Sabrina Lusvarghi, Suresh V. Ambudkar, Ning Ji, Zhe-Sheng Chen   +8 more
doaj   +1 more source

Dynamic induction of drug resistance through a stress-responsive enhancer in acute myeloid leukemia

Molecular & Cellular Oncology, 2020
The drug efflux pump ABCB1 (ATP binding cassette subfamily B member 1) confers chemotherapy resistance in acute myeloid leukemia (AML). We recently identified an ABCB1 enhancer that is activated in response to a range of cellular stressors, including ...
Mark S. Williams, Tim C. P. Somervaille
doaj   +1 more source