Results 191 to 200 of about 40,232 (213)

Genuine Functions of P-Glycoprotein (ABCB1)

Current Drug Metabolism, 2008
P-glycoprotein (P-gp, ABCB1, MDR1) was recognized as a drug-exporting protein from cancer cells three decade ago. Apart from the multidrug transporter side effects of P-gp, normal physiological functions of P-gp have been reported. P-gp could be responsible for translocating platelet-activating factor (PAF) across the plasma membrane and PAF inhibited ...
Takaharu, Mizutani, Masatoshi, Masuda, Emi, Nakai, Kenji, Furumiya, Hiroshi, Togawa, Yutaka, Nakamura, Yuko, Kawai, Keiko, Nakahira, Shigeko, Shinkai, Kazuhiko, Takahashi   +9 more
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ABCB1 Pharmacogenetics: Progress, Pitfalls, and Promise

Clinical Pharmacology & Therapeutics, 2007
In 1976, Juliano and Ling(1) reported expression of a 170 kDa protein in colchicine-resistant Chinese hamster ovary (CHO) cells that was absent in drug-sensitive cells. Because this protein altered cellular permeability to colchicine, the authors named it P-glycoprotein (P-gp).(1) P-gp overexpression was described in tumor samples and leukemic cells.(2)
L W, Chinn, D L, Kroetz
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ABCB1

pharma-kritik, 2017
Mit der Genotypisierung des ABCB1-Gens – das das P-Glykoprotein enkodiert – soll eine wirksamere Antidepressiva-Therapie möglich sein. Bisher ist ungenügend dokumentiert, dass dies der Fall ist.    
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Breed distribution of the ABCB1-1Δ (multidrug sensitivity) polymorphism among dogs undergoing ABCB1 genotyping

Journal of the American Veterinary Medical Association, 2008
Abstract Objective—To evaluate the breed distribution of the ABCB1-1Δ polymorphism in a large number of dogs in North America, including dogs of several herding breeds in which this polymorphism has been detected and other breeds in which this polymorphism has not yet been identified. Design—Cross-sectional study.
Katrina L, Mealey, Kathryn M, Meurs
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ABCB1 and Cytochrome P450 Polymorphisms

Journal of Clinical Psychopharmacology, 2009
To examine the genetic factors influencing clozapine kinetics in vivo, 75 patients treated with clozapine were genotyped for CYPs and ABCB1 polymorphisms and phenotyped for CYP1A2 and CYP3A activity. CYP1A2 activity and dose-corrected trough steady-state plasma concentrations of clozapine correlated significantly (r = -0.61; P = 1 x 10), with no ...
Jaquenoud Sirot, Eveline, Knezevic, Branka, Morena, Gina Perla, Harenberg, Sabine, Oneda, Beatrice, Crettol, Severine, Ansermot, Nicolas, Baumann, Pierre, Eap, Chin B   +8 more
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Estimation of ABCB1 concentration in plasma membrane

Journal of Cellular Biochemistry, 2019
AbstractThe interaction between ABCB1 transporter and its substrates takes place in cell membranes but the available data precludes quantitative analysis of the interaction between transporter and substrate molecules. Further, the amount of transporter is usually expressed as a number of ABCB1 molecules per cell.
Petr Mlejnek, Petr Kosztyu, Petr Dolezel, Yasuhisa Kimura, Katerina Cizkova, Eliska Ruzickova   +5 more
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ABCB1 Genotyping in the Treatment of Depression

Pharmacogenomics, 2016
P-glycoprotein (P-gp), the gene product of ABCB1, is a drug transporter at the blood-brain barrier and could be a limiting factor for entrance of antidepressants into the brain, the target site of antidepressant action. Animal studies showed that brain concentrations of many antidepressants depend on P-gp.
Brückl, T., Uhr, M.
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Functioning of ABCB1 protein in pregnancy

Voprosy ginekologii, akušerstva i perinatologii, 2023
Objective. To study the functioning of ABCB1 protein in pregnancy, namely, to evaluate its amount in the organs that play a significant role in pharmacokinetics and its functional activity at the whole organism level. Materials and methods. The study was performed on 52 female rabbits divided into two groups.
N.M. Popova, A.V. Shchulkin, P.Yu. Mylnikov, I.V. Chernykh, E.N. Yakusheva   +4 more
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ABCB1 gene polymorphism in nephrotic syndrome

Comparative Clinical Pathology, 2018
Nephrotic syndrome is the most prevalent glomerular disease in childhood. This study illustrates distribution of the most common three multidrug resistance gene 1 MDR1 (ABCB1) exonic polymorphisms G3435C, G2677 T/A, and C1236T in children with NS to assess their ability to be used as markers for response of NS to steroids.
Faten Zahran Mohammed, Mohamed Magdy Zedan, Mona Abo Bakr El-Hussiny, Lamiaa Abd El-Lateaf Ali Barakat, Mohamed Adel Abd El-Motelb El-Eshmawy   +4 more
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