Results 41 to 50 of about 40,232 (213)
Analytical Validation of Variants to Aid in Genotype-Guided Therapy for Oncology [PDF]
, 2019 The Clinical Laboratory Improvement Amendments (CLIA) of 1988 requires that pharmacogenetic genotyping methods need to be established according to technical standards and laboratory practice guidelines before testing can be offered to patients.
Kiel, Patrick J. +7 more
core +1 more source
Karanjin interferes with ABCB1, ABCC1, and ABCG2 [PDF]
Journal of Pharmacy & Pharmaceutical Sciences, 2014 PURPOSE: The prominent ATP-binding cassette (ABC) transporters ABCB1, ABCC1, and ABCG2 are involved in substance transport across physiological barriers and therefore in drug absorption, distribution, and elimination. They also mediate multi-drug resistance in cancer cells.
Martin Michaelis +5 more
openaire +4 more sources
Opioid-induced respiratory depression: ABCB1 transporter pharmacogenetics [PDF]
The Pharmacogenomics Journal, 2014 Opioid-related respiratory depression (RD) is a serious clinical problem as it causes multiple deaths and anoxic brain injuries. Morphine is subject to efflux via P-glycoprotein transporter encoded by ABCB1, also known as MDR1. ABCB1 polymorphisms may affect blood-brain barrier transport of morphine and therefore individual response to its central ...
S Sadhasivam +7 more
openaire +2 more sources
Медицинский совет, 2020 Background: despite well-studied safety profile of dabigatran its interactions with genetic polymorphism parameters are poorly understood, especially in patients with moderate chronic kidney disease (CKD).
A. I. Skripka +12 more
doaj +1 more source
Rivaroxaban-Induced Hemorrhage Associated with ABCB1 Genetic Defect [PDF]
Frontiers in Pharmacology, 2016 We report a patient who presented a non-ST segment elevation myocardial infarction in the context of severe normocytic hypochromic anemia related to gastrointestinal bleeding, 3 months after switching anticoagulant from the vitamin K antagonist acenocoumarol to the direct oral anticoagulant rivaroxaban.
Ing Lorenzini, Kuntheavy +4 more
openaire +4 more sources
Frontiers in Pharmacology, 2021 The emergence of multidrug resistance (MDR) has been a major issue for effective cancer chemotherapy as well as targeted therapy. One prominent factor that causes MDR is the overexpression of ABCB1 transporter.
Zhuo-Xun Wu +8 more
doaj +1 more source
The cyclophilin A DIAGEOTROPICA gene affects auxin transport in both root and shoot to control lateral root formation [PDF]
, 2015 Cyclophilin A is a conserved peptidyl-prolyl cis-trans isomerase (PPIase) best known as the cellular receptor of the immunosuppressant cyclosporine A. Despite significant effort, evidence of developmental functions of cyclophilin A in non-plant systems ...
Azzarello, Elisa +11 more
core +2 more sources
Molecules, 2016 In recent years, tyrosine kinase inhibitors (TKIs) have been shown capable of inhibiting the ATP-binding cassette (ABC) transporter-mediated multidrug resistance (MDR). In this study, we determine whether osimertinib, a novel selective, irreversible EGFR
Xiao-Yu Zhang +8 more
doaj +1 more source
Individualized immunosuppression in transplant patients: potential role of pharmacogenetics. [PDF]
, 2012 The immunosuppressive drugs used to prevent the rejection of transplanted organs have a narrow therapeutic index. Under treatment results in episodes of rejection leading to either damage or loss of the organ. Over immunosuppression increases the risk of
Abboudi, H, Macphee, IA
core +2 more sources
Presence of the ABCB1 (MDR1) deletion mutation causing ivermectin hypersensitivity in certain dog breeds in Belgium [PDF]
, 2009 Hypersensitivity to ivermectin and certain other drugs in Collies and related breeds is caused by a 4-base pair deletion mutation in the ABCB1 gene, better known as the MDR1 gene, encoding P-glycoprotein.
Daminet, Sylvie +9 more
core +2 more sources