Results 61 to 70 of about 40,232 (213)

Adagrasib, a KRAS G12C inhibitor, reverses the multidrug resistance mediated by ABCB1 in vitro and in vivo

Cell Communication and Signaling, 2022
Background Multidrug resistance (MDR) is a complex phenomenon that frequently leads to chemotherapy failure during cancer treatment. The overexpression of ATP-binding cassette (ABC) transporters represents the major mechanism contributing to MDR. To date,
Yuchen Zhang, Cheukfai Li, Chenglai Xia, Keneth Kin Wah To, Zhixing Guo, Chongyang Ren, Lingzhu Wen, Fang Wang, Liwu Fu, Ning Liao   +9 more
doaj   +1 more source

Substrate-specific effects of pirinixic acid derivatives on ABCB1-mediated drug transport [PDF]

, 2016
Pirinixic acid derivatives, a new class of drug candidates for a range of diseases, interfere with targets including PPARα, PPARγ, 5-lipoxygenase (5-LO), and microsomal prostaglandin and E2 synthase-1 (mPGES1).
Baba, Cascorbi, Chang, Cinatl, Cinatl, Cinatl, Cinatl, Clarke, Cory, Ferreira, Gescher, Gottesman, Grygiel-Górniak, Gudkov, Gupta, Gütschow, Kanda, Kornhuber, Liu, Mack, Mansour, Reiss, Rizzo, Samuelsson, Sarkadi, Schubert-Zsilavecz, Schubert-Zsilavecz, Schubert-Zsilavecz, Spengler, Steinhilber, Tomarelli, Werz, Werz, Werz, Westermann, Wiese, Zettl   +36 more
core   +1 more source

Differential effect of ABCB1 haplotypes on promoter activity [PDF]

Pharmacogenetics and Genomics, 2018
Promoter single-nucleotide polymorphisms (SNPs) of the ABCB1 gene, encoding the placental efflux transporter P-glycoprotein, can affect its expression and alter xenobiotic transfer from the maternal to the fetal circulation. Because SNPs are arranged in specific combinations as defined haplotypes, the aims of this study were to: (i) determine the ...
Jordan T, Speidel, Meixiang, Xu, Sherif Z, Abdel-Rahman   +2 more
openaire   +2 more sources

Mechanical Stimuli‐Induced Manipulation of Malignant Behavior in Bioprinted Cancer Microtissues via PI3K/NF‐κB Activation

Advanced Science, EarlyView.
A mechanically tunable ECM platform is created by integrating dECM–alginate matrices with in‐bath tumor printing. The mechanically tunable ECM environment drives tumors to acquire hypoxia, mechanotransduction signaling, metastatic traits, and drug‐resistant phenotypes that collectively promote malignant transformation.
Seok‐Hyeon Lee, Jeongho Lee, Min‐Seo Choi, Minjun Ahn, Sik Yoon, Dongjun Lee, Sae‐Ock Oh, Won‐Woo Cho, Byoung Soo Kim   +8 more
wiley   +1 more source

ML210 Antagonizes ABCB1- Not ABCG2-Mediated Multidrug Resistance in Colorectal Cancer

Biomedicines
Objectives: ABCB1-mediated multidrug resistance (MDR) compromises chemotherapy efficacy in colorectal cancer (CRC). Despite decades of research, no selective ABCB1 inhibitor has achieved clinical success.
Yan-Chi Li, Yu-Meng Xiong, Ze-Ping Long, Yi-Ping Huang, Yu-Bin Shu, Ke He, Hong-Yan Sun, Zhi Shi   +7 more
doaj   +1 more source

ABCB1 (MDR1) induction defines a common resistance mechanism in paclitaxel- and olaparib-resistant ovarian cancer cells [PDF]

, 2016
BACKGROUND: Clinical response to chemotherapy for ovarian cancer is frequently compromised by the development of drug-resistant disease. The underlying molecular mechanisms and implications for prescription of routinely prescribed chemotherapy drugs are ...
A Eva, A Sonnenblick, A Tutt, AA Ahmed, AG Patel, Alison L Scott, AM Oza, AM Patch, Anne-Louise Gannon, Aparajitha Vaidyanathan, AR Safa, AT Fojo, B Norquist, BI Sikic, CK Ingemarsdotter, D Lawlor, DA Zajchowski, DW Shen, E Dean, EM Swisher, F Hyafil, F Micci, G Konecny, G Smith, G Wurzer, G Xu, Gillian Smith, GK Smyth, H Chang, H Farmer, H Green, H Parekh, H Thomas, HE Bryant, HS Kim, IE Dumitriu, J Tapper, J Wesierska-Gadek, JD Allen, JE Jaspers, JE Jaspers, JF Liu, JM Lee, K Partheen, L Liu, LY Tao, Lynne Sawers, M Boesch, M Rouleau, M Yun, Michelle J Ferguson, MM Cornwell, MN Fransson, MW Audeh, N Johnson, N Syed, Probir Chakravarty, R Cincinelli, RF Ozols, RJ Kathawala, RJ Kelly, RJ Kelly, RT Penson, RW Martin, S Arao, S Durmus, S Marsh, S Rottenberg, S Vaughan, SE Johnatty, SL Edwards, SP Langdon, Susan E Bray, T Krech, T Mosmann, TA Holzmayer, V Materna, W Sakai, X Yang, YC Wang   +79 more
core   +3 more sources

Effect of developmental changes on pharmacokinetics of drugs used in the treatment of infant acute lymphoblastic leukaemia—A comprehensive review

British Journal of Clinical Pharmacology, EarlyView.
While the event‐free survival (EFS) of children treated for acute lymphoblastic leukaemia (ALL) has improved greatly in the last decades, the EFS for patients diagnosed with ALL before the age of one is still under 50%. This outcome further decreases when infants have a rearrangement in the gene encoding histone‐lysine N‐methyltransferase 2A (KMT2A ...
Tirsa de Kluis, Leiah J. Brigitha, Lidwien M. Hanff, Alwin D. R. Huitema, Inge M. van der Sluis, Meta H. M. Diekstra   +5 more
wiley   +1 more source

Cannabinoids and drug–drug pharmacokinetic interactions: Deciphering the risks

British Journal of Clinical Pharmacology, EarlyView.
The relationship between cannabinoids and mental health has become a major focus of scientific inquiry and public discourse. Cannabinoids are diverse chemical compounds from the Cannabis species that have been explored for their therapeutic applications in treating chronic pain, psychiatric and neurological conditions, such as depression, schizophrenia,
Paraskevi Papakyriakopoulou, Georgia Valsami, Georgios Ismailos   +2 more
wiley   +1 more source

Overcoming multiple drug resistance mechanisms in medulloblastoma [PDF]

, 2014
Introduction: Medulloblastoma (MB) is the most common malignant paediatric brain tumour. Recurrence and progression of disease occurs in 15-20% of standard risk and 30-40% of high risk patients.
Andrey Korshunov, Beth Coyle, Ian D Kerr, Ioanna Kimishi, Lisa CD Storer, Othman, Ramadhan T, Ramadhan RamadhanT Othman, Richard G Grundy, Stefan M Pfister, Tracey D Bradshaw   +9 more
core   +1 more source

Assessing transporter‐mediated rifampin–linezolid interaction using physiologically‐based pharmacokinetic modelling

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims The study aims to develop a physiologically‐based pharmacokinetic (PBPK) model to quantitatively evaluate the role of ATP‐binding cassette sub‐family B member 1 (ABCB1) and ATP‐binding cassette super‐family G member 2 (ABCG2) in the drug–drug interaction (DDI) between rifampin and linezolid and to predict the impact of high‐dose rifampin ...
Hoang Dat Nguyen, Vinh Hoa Pham, Richard M. Hoglund, Joel Tarning, Junjie Ding   +4 more
wiley   +1 more source