Results 91 to 100 of about 3,455 (202)

Receptor‐Dependent and ‐Independent Effects of Hemin on Platelet Plasma Membrane Disintegration

The FASEB Journal, Volume 40, Issue 2, 31 January 2026.
Microhemorrhages lead to the release of erythrocytes, which are then degraded and lysed. These hemolyses result in the liberation of free iron‐containing hemin. Hemin induces platelet activation and ferroptosis. Inhibition of GPVI/CLEC‐2 receptor‐mediated ITAM‐signaling inhibits hemin‐induced platelet activation (low hemin concentrations). Deferoxamine,
Zoi Laspa, Anne‐Katrin Rohlfing, Ravi Hochuli, Pamela Weronika Sowa, Tatsiana Castor, Meinrad Paul Gawaz   +5 more
wiley   +1 more source

Atypical Chemokine Receptor 3 Generates Guidance Cues for CXCL12-Mediated Endothelial Cell Migration

Frontiers in Immunology, 2019
Chemokine receptor CXCR4, its ligand stromal cell-derived factor-1 (CXCL12) and the decoy receptor atypical chemokine receptor 3 (ACKR3, also named CXCR7), are involved in the guidance of migrating cells in different anatomical districts.
Chiara Tobia, Paola Chiodelli, Andrea Barbieri, Simone Buraschi, Elena Ferrari, Stefania Mitola, Giuseppe Borsani, Jessica Guerra, Marco Presta   +8 more
doaj   +1 more source

Single-cell transcriptomic analysis reveals differential cell subpopulations and distinct phenotype transition in normal and dissected ascending aorta

Molecular Medicine, 2022
Background Acute thoracic aortic dissection (ATAD) is a fatal condition characterized by tear of intima, formation of false lumen and rupture of aorta. However, the subpopulations of normal and dissected aorta remain less studied. Methods Single-cell RNA
Yu-bin He, Hai-zhen Jin, Jin-long Zhao, Chong Wang, Wen-rui Ma, Jie Xing, Xiao-bin Zhang, Yang-yang Zhang, Huang-dong Dai, Nai-shi Zhao, Jian-feng Zhang, Guan-xin Zhang, Jing Zhang   +12 more
doaj   +1 more source

Single‐Cell RNA Sequencing Analysis Reveals Correlation Between Immune Cell Composition and Gene Expression in Cervical Cancer

Journal of Cellular and Molecular Medicine, Volume 30, Issue 2, January 2026.
ABSTRACT Cervical cancer has become a glaring concern for women's health globally. The use of single‐cell RNA sequencing (scRNA‐seq) contributes to a comprehensive understanding of cellular heterogeneity and the immune cell landscape in the TME of cervical cancer.
Changchang Huang, Guosha Pang, Xiaolin Lang, Jingjing Zhang, Fen Zhao   +4 more
wiley   +1 more source

Selective Elimination of Senescent Fibroblasts by Targeting the Cell Surface Protein ACKR3

International Journal of Molecular Sciences, 2022
The accumulation of senescent cells in aging tissues is associated with age-related diseases and functional decline. Thus, senolysis, a therapy aimed at rejuvenation by removing senescent cells from the body, is being developed. However, this therapy requires the identification of membrane surface antigens that are specifically expressed on senescent ...
Kento Takaya, Toru Asou, Kazuo Kishi
openaire   +2 more sources

Combining Genome Wide Association Studies and Differential Gene Expression Data Analyses Identifies Candidate Genes Affecting Mastitis Caused by Two Different Pathogens in the Dairy Cow [PDF]

, 2015
Mastitis is a costly disease which hampers the dairy industry. Inflammation of the mammary gland is commonly caused by bacterial infection, mainly Escherichia coli, Streptococcus uberis and Staphylococcus aureus.
Chen, X, Cheng, Z R, Wathes, D C, Werling, D, Zhang, S   +4 more
core   +3 more sources

Targeting Mast Cell Activation and MIF‐Mediated Remodelling Enhances Chemotherapy Response in Pancreatic Cancer

Advanced Science, Volume 12, Issue 48, December 29, 2025.
Neoadjuvant gemcitabine plus nab‐paclitaxel (AG) reprograms pancreatic ductal adenocarcinoma by shifting malignant cells toward a classical phenotype and remodeling the tumor microenvironment. Despite enhancing cytotoxic NKT cells, AG activates tumor‐associated mast cells (TAMCs) and inflammatory CAFs through MIF signaling.
Libo Wang, Guangcong Shen, Guanpeng Xie, Zekun Li, Xiaoqing Ma, Mengyu Li, Ziyun Liu, Yadi Wang, Zongjing Lv, Qingxiao Fang, Huihui Sun, Ningning Zhao, Chao Yang, Tianxing Zhou, Yongjie Xie, Jun Yu, Jihui Hao   +16 more
wiley   +1 more source

Multisystem multitasking by CXCL12 and its receptors CXCR4 and ACKR3

Cytokine, 2018
Chemokines are named and best known for their chemotactic cytokine activity in the hematopoietic system; however, their importance extends far beyond leukocytes, cell movement and immunoregulation. CXCL12, the most protean of chemokines, regulates development in multiple systems, including the hematopoietic, cardiovascular and nervous systems, and ...
Philip M, Murphy, Lauren, Heusinkveld
openaire   +3 more sources

Correction: del Molino del Barrio et al. Breast Cancer: An Examination of the Potential of ACKR3 to Modify the Response of CXCR4 to CXCL12. Int. J. Mol. Sci. 2018, 19, 3592

International Journal of Molecular Sciences, 2023
The authors and Editorial Office were made aware of an error in a figure within the original publication [...].
Irene del Molino del Barrio, Georgina C Wilkins, A. Meeson, Simi Ali, John A Kirby   +4 more
semanticscholar   +1 more source

2,3,7,8-Tetrachlorodibenzo-p-dioxin-induced RNA abundance changes identify Ackr3, Col18a1, Cyb5a and Glud1 as candidate mediators of toxicity [PDF]

, 2016
PMID: 27136898Peer ...
Boutros, Paul C, Okey, Allan B, Pohjanvirta, Raimo, Prokopec, Stephenie D., Smith, Ashley B., Watson, John D.   +5 more
core   +1 more source