GPR182 is a broadly scavenging atypical chemokine receptor influencing T-independent immunity [PDF]
Frontiers in Immunology, 2023 Immune responses highly depend on the effective trafficking of immune cells into and within secondary lymphoid organs (SLOs). Atypical chemokine receptors (ACKRs) scavenge chemokines to eliminate them from the extracellular space, thereby generating ...
Serena Melgrati +16 more
doaj +3 more sources
ACKR3–arrestin2/3 complexes reveal molecular consequences of GRK-dependent barcoding
bioRxiv, 2023 Atypical chemokine receptor 3 (ACKR3, also known as CXCR7) is a scavenger receptor that regulates extracellular levels of the chemokine CXCL12 to maintain responsiveness of its partner, the G protein-coupled receptor (GPCR), CXCR4.
Qiuyan Chen +8 more
semanticscholar +3 more sources
Modulation of non-canonical CXCR4 and ACKR3 functions [PDF]
The large family of G protein-coupled receptor (GPCR) family transduce extracellular signals via diverse signaling pathways to control physiological functions.
Perez Almeria, Claudia Victoria
core +2 more sources
Lymphatic Activation of ACKR3 Signaling Regulates Lymphatic Response After Ischemic Heart Injury
Arteriosclerosis, Thrombosis, and Vascular BiologyBACKGROUND: Ischemic heart disease is a prevalent cause of death and disability worldwide. Recent studies reported a rapid expansion of the cardiac lymphatic network upon ischemic heart injury and proposed that cardiac lymphatics may attenuate tissue ...
László Bálint +7 more
semanticscholar +5 more sources
The discovery of small-molecule modulators for the ACKR3 receptor [PDF]
, 2023 The atypical chemokine receptor 3 (ACKR3) is an attractive drug target for a new generation of chemotherapies. The inhibition of chemokine binding to ACKR3 by small-molecule agonists has shown reduced cancer activity in vivo and in vitro.
Riemens, Rick
core +3 more sources
The atypical chemokine receptor ACKR3/CXCR7 is a broad-spectrum scavenger for opioid peptides
Nature Communications, 2020 Opioids modulate pain, anxiety and stress by activating four subtypes of opioid receptors. The authors show that atypical chemokine receptor 3 (ACKR3) is a scavenger for various endogenous opioid peptides regulating their availability without activating ...
Max Meyrath +13 more
doaj +2 more sources
Structural basis for selectivity and antagonism in extracellular GPCR-nanobodies [PDF]
Nature CommunicationsG protein-coupled receptors (GPCRs) are pivotal therapeutic targets, but their complex structure poses challenges for effective drug design. Nanobodies, or single-domain antibodies, have emerged as a promising therapeutic strategy to target GPCRs ...
Roman R. Schlimgen +5 more
doaj +2 more sources
Endothelial ACKR3 drives atherosclerosis by promoting immune cell adhesion to vascular endothelium [PDF]
Basic Research in Cardiology, 2022 Atherosclerosis is the foundation of potentially fatal cardiovascular diseases and it is characterized by plaque formation in large arteries. Current treatments aimed at reducing atherosclerotic risk factors still allow room for a large residual risk ...
S. Gencer +15 more
semanticscholar +6 more sources
The Role of the CXCL12/CXCR4/ACKR3 Axis in Autoimmune Diseases [PDF]
Frontiers in Endocrinology, 2019 Chemokine receptors are members of the G protein-coupled receptor superfamily. These receptors are intimately involved in cell movement, and thus play a critical role in several physiological and pathological situations that require the precise ...
Eva M. García-Cuesta +5 more
doaj +5 more sources
Single-cell RNA sequencing reveals the potential role of Postn(+) fibroblasts in promoting the progression of myocardial fibrosis after myocardial infarction [PDF]
Scientific ReportsMyocardial infarction (MI) is a life-threatening coronary artery-related pathology characterized by sudden cardiac death, often leading to cardiac fibrosis and heart failure (HF).
Wenyang Nie +6 more
doaj +2 more sources