Results 41 to 50 of about 3,165 (181)

Targeting CXCR7/ACKR3 as a therapeutic strategy to promote remyelination in the adult central nervous system [PDF]

, 2014
Current treatment modalities for the neurodegenerative disease multiple sclerosis (MS) use disease-modifying immunosuppressive compounds but do not promote repair. Although several potential targets that may induce myelin production have been identified,
Arnett, Bajetto, Banisadr, Boldajipour, Brian P. Daniels, Calderon, Carbajal, Carbajal, Chang, Chang, Compston, Cruz-Orengo, Cruz-Orengo, Dziembowska, Franklin, Göttle, Hatse, Imitola, Jessica L. Williams, Jigisha R. Patel, Klein, Kuhlmann, Lindner, Matsuo, McCandless, McCandless, Naumann, Patel, Patel, Robyn S. Klein, Schönemeier, Steinman, Wolswijk, Xu, Zhu, Zou   +35 more
core   +2 more sources

CXCL12/SDF-1 from perisynaptic Schwann cells promotes regeneration of injured motor axonterminals [PDF]

, 2017
The neuromuscular junction has retained through evolution the capacity to regenerate after damage, but little is known on the inter-cellular signals involved in its functional recovery from trauma, autoimmune attacks, or neurotoxins.
Aram Megighian, Bagri A, Cesare Montecucco, Chiara M Mazzanti, Egle Radice, Elisa Duregotti, Elisanna Bergamin, Francesca Lessi, Guyon A, Marco La Ferla, Marco Pirazzini, Marcus Thelen, Michela Rigoni, Michele Menicagli, Paolo Aretini, Samuele Negro, Sara Franceschi, Shellard A   +17 more
core   +1 more source

Elevated ACKR2 expression is a common feature of inflammatory arthropathies [PDF]

, 2017
Objectives. Chemokines are essential contributors to leucocyte accumulation at sites of inflammatory pathology. Interfering with chemokine or chemokine receptor function therefore represents a plausible therapeutic option.
Baldwin, Helen M., Codullo, Veronica, Graham, Gerard J., King, Vicky, McInnes, Iain, Singh, Mark D., Wilson, Hilary   +6 more
core   +1 more source

Atypical chemokine receptor ACKR2 controls branching morphogenesis in the developing mammary gland [PDF]

, 2016
Macrophages are important regulators of branching morphogenesis during development and postnatally in the mammary gland. Regulation of macrophage dynamics during these processes can therefore have a profound impact on development.
Cairney, Claire J., Graham, Gerard J., Hansell, Christopher A., Hewit, Kay D., Lee, Kit M., Pallas, Kenneth J., Stein, Torsten, Wilson, Gillian J.   +7 more
core   +1 more source

Chemokines in the balance: Maintenance of homeostasis and protection at CNS barriers [PDF]

, 2014
In the adult central nervous system (CNS), chemokines and their receptors are involved in developmental, physiological and pathological processes. Although most lines of investigation focus on their ability to induce the migration of cells, recent ...
Holman, David W, Klein, Robyn S, Williams, Jessica L   +2 more
core   +3 more sources

α1‐Adrenergic Receptors Function Within Hetero‐Oligomeric Complexes With Atypical Chemokine Receptor 3 and Chemokine (C‐X‐C motif) Receptor 4 in Vascular Smooth Muscle Cells

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundRecently, we provided evidence that α1‐adrenergic receptors (ARs) in vascular smooth muscle are regulated by chemokine (C‐X‐C motif) receptor (CXCR) 4 and atypical chemokine receptor 3 (ACKR3). While we showed that CXCR4 controls α1‐ARs through
Lauren J. Albee, Jonathan M. Eby, Abhishek Tripathi, Heather M. LaPorte, Xianlong Gao, Brian F. Volkman, Vadim Gaponenko, Matthias Majetschak   +7 more
doaj   +1 more source

Circulating hsa_circ_0072309, acting via the miR‐100/ACKR3 pathway, maybe a potential biomarker for the diagnosis, prognosis, and treatment of brain metastasis from non‐small‐cell lung cancer

Cancer Medicine, 2023
Background One of the main causes of lung cancer‐related death is brain metastasis (BM). Finding early indicators of BM derived from lung cancer is crucial.
Xiao‐Qiang Zhang, Qian Song, Lin‐Xiang Zeng   +2 more
doaj   +1 more source

Single-cell RNA sequencing identifies distinct mouse medial ganglionic eminence cell types. [PDF]

, 2017
Many subtypes of cortical interneurons (CINs) are found in adult mouse cortices, but the mechanism generating their diversity remains elusive. We performed single-cell RNA sequencing on the mouse embryonic medial ganglionic eminence (MGE), the major ...
Chen, Ying-Jiun J, Durinck, Steffen, Friedman, Brad A, Ha, Connie, Liu, Jinfeng, Modrusan, Zora, Rubenstein, John L, Seshagiri, Somasekar   +7 more
core   +1 more source

From Insight to Modulation of CXCR4 and ACKR3 (CXCR7) Function [PDF]

Molecular Pharmacology, 2019
Chemokine receptors CXCR4 and atypical chemokine receptor 3 (ACKR3/CXCR7) are highly expressed in a range of tumors. Yet, their role in cancer progression is not well understood. This minireview series encompasses seven comprehensive reviews focusing on modulators (small molecules, pepducins, antibodies), structural aspects, spatio-temporal signaling ...
Smit, Martine J., van Muijlwijk-Koezen, Jacqueline E.   +1 more
openaire   +3 more sources

The atypical chemokine receptor 3 interacts with Connexin 43 inhibiting astrocytic gap junctional intercellular communication

Nature Communications, 2020
The atypical chemokine receptor 3 (ACKR3) is known to regulate cell migration, but the underlying mechanisms are unclear. Here, the authors show, from an interactome analysis, ACKR3 association with the gap junction protein Connexin 43 in vivo and ACKR3 ...
Amos Fumagalli, Joyce Heuninck, Anne Pizzoccaro, Enora Moutin, Joyce Koenen, Martial Séveno, Thierry Durroux, Marie-Pierre Junier, Géraldine Schlecht-Louf, Francoise Bachelerie, Dagmar Schütz, Ralf Stumm, Martine J. Smit, Nathalie C. Guérineau, Séverine Chaumont-Dubel, Philippe Marin   +15 more
doaj   +1 more source