Roxadustat Attenuates Adverse Remodeling Following Myocardial Infarction in Mice [PDF]
CellsActivation of the CXCL12/CXCR4/ACKR3 axis is known to aid myocardial repair through ischemia-triggered hypoxia-inducible factor-1α (HIF-1α). To enhance the upregulation of HIF-1α, we administered roxadustat, a novel prolyl hydroxylase inhibitor (PHI ...
Marc-Michael Zaruba +10 more
doaj +2 more sources
MIF-ACKR3 causes irreversible fat loss by impairing adipogenesis in cancer cachexia.
Cell MetabolismBoth exercise and cancer can cause adipose tissue shrinkage. However, only cancer-associated weight loss, namely cachexia, is characterized by profound adipose inflammation and fibrosis. Here, we identified tumor-secreted macrophage migration inhibitory factor (MIF) as a major driver that skews the differentiation of adipose stem and progenitor cells ...
Qionghua Cui +11 more
semanticscholar +3 more sources
Regulation of the chemokine receptors CXCR4 and ACKR3 by receptor activity-modifying proteins. [PDF]
J Biol ChemPfersdorf F +3 more
europepmc +2 more sources
Identification and functional characterization of arginine vasopressin receptor 1A : atypical chemokine receptor 3 heteromers in vascular smooth muscle [PDF]
Open Biology, 2018 Recent observations suggest that atypical chemokine receptor (ACKR)3 and chemokine (C-X-C motif) receptor (CXCR)4 regulate human vascular smooth muscle function through hetero-oligomerization with α1-adrenoceptors. Here, we show that ACKR3 also regulates
Lauren J. Albee +8 more
doaj +1 more source
PLoS ONE, 2021 Atypical chemokine receptor ACKR3 (formerly CXCR7) is a scavenging receptor that has recently been implicated in murine lymphatic development. Specifically, ACKR3-deficiency was shown to result in lymphatic hyperplasia and lymphedema, in addition to ...
Elena C Sigmund +8 more
doaj +1 more source
Subarachnoid hemorrhage alters CX43 and ACKR3 levels in cerebrospinal fluid: A preclinical study
Asian Journal of Surgery, 2023 Jian Yan +3 more
doaj +2 more sources
Novel atypical G protein-coupled receptor (GPCR)-arrestin complexes: a structural snapshot of the barcode hypothesis. [PDF]
Signal Transduct Target TherFilor JC, Matthees ESF, Hoffmann C.
europepmc +3 more sources
Antibodies Targeting Chemokine Receptors CXCR4 and ACKR3 [PDF]
Molecular Pharmacology, 2019 Dysregulation of the chemokine system is implicated in a number of autoimmune and inflammatory diseases, as well as cancer. Modulation of chemokine receptor function is a very promising approach for therapeutic intervention. Despite interest from academic groups and pharmaceutical companies, there are currently few approved medicines targeting ...
Bobkov, Vladimir +6 more
openaire +4 more sources
Effects of Small Molecule Ligands on ACKR3 Receptors
Molecular Pharmacology, 2022 Chemokines such as stromal derived factor 1 and their G protein coupled receptors are well-known regulators of the development and functions of numerous tissues. C-X-C motif chemokine ligand 12 (CXCL12) has two receptors: C-X-C chemokine motif receptor 4 (CXCR4) and atypical chemokine receptor 3 (ACKR3). ACKR3 has been described as an atypical "biased"
Hopkins, Brittany E. +8 more
openaire +2 more sources
Differential Involvement of ACKR3 C-Tail in β-Arrestin Recruitment, Trafficking and Internalization
Cells, 2021 Background: The atypical chemokine receptor 3 (ACKR3) belongs to the superfamily of G protein-coupled receptors (GPCRs). Unlike classical GPCRs, this receptor does not activate G proteins in most cell types but recruits β-arrestins upon activation. ACKR3
Aurélien Zarca +9 more
doaj +1 more source