The atypical chemokine receptor Ackr2 constrains NK cell migratory activity and promotes metastasis [PDF]
, 2018 Chemokines have been shown to be essential players in a range of cancer contexts. In this study, we demonstrate that mice deficient in the atypical chemokine receptor Ackr2 display impaired development of metastasis in vivo in both cell line and ...
Brownlie, Demi +12 more
core +1 more source
The G protein-coupled receptor heterodimer network (GPCR-HetNet) and its hub components [PDF]
, 2014 G protein-coupled receptors (GPCRs) oligomerization has emerged as a vital characteristic of receptor structure. Substantial experimental evidence supports the existence of GPCR-GPCR interactions in a coordinated and cooperative manner.
Agnati, Luigi F +12 more
core +4 more sources
Glia Cells Control Olfactory Neurogenesis by Fine-Tuning CXCL12
Cells, 2023 Olfaction depends on lifelong production of sensory neurons from CXCR4 expressing neurogenic stem cells. Signaling by CXCR4 depends on the concentration of CXCL12, CXCR4’s principal ligand.
André Dietz +4 more
doaj +1 more source
Effects of cognate, non-cognate and synthetic CXCR4 and ACKR3 ligands on human lung endothelial cell barrier function. [PDF]
PLoS ONE, 2017 Recent evidence suggests that chemokine CXCL12, the cognate agonist of chemokine receptors CXCR4 and ACKR3, reduces thrombin-mediated impairment of endothelial barrier function.
You-Hong Cheng +4 more
doaj +1 more source
Evaluation of Atypical Chemokine Receptor Expression in T Cell Subsets
Cells, 2022 Chemokines are molecules that pertain to a family of small cytokines and can generate cell chemotaxis through the interaction with their receptors.
Messias Oliveira Pacheco +3 more
doaj +1 more source
Chemotactic Cues for NOTCH1-Dependent Leukemia [PDF]
, 2018 The NOTCH signaling pathway is a conserved signaling cascade that regulates many aspects of development and homeostasis in multiple organ systems.
Amadori, Alberto +3 more
core +1 more source
Endothelial ACKR3 drives atherosclerosis by promoting immune cell adhesion to vascular endothelium [PDF]
Basic Research in Cardiology, 2022 AbstractAtherosclerosis is the foundation of potentially fatal cardiovascular diseases and it is characterized by plaque formation in large arteries. Current treatments aimed at reducing atherosclerotic risk factors still allow room for a large residual risk; therefore, novel therapeutic candidates targeting inflammation are needed.
Selin Gencer +15 more
openaire +5 more sources
CRISPR-Mediated Protein Tagging with Nanoluciferase to Investigate Native Chemokine Receptor Function and Conformational Changes [PDF]
, 2020 © 2020 The Authors G protein-coupled receptors are a major class of membrane receptors that mediate physiological and pathophysiological cellular signaling.
Caspar, Birgit +4 more
core +3 more sources
RIPK3 restricts viral pathogenesis via cell death-independent neuroinflammation [PDF]
, 2017 Receptor-interacting protein kinase-3 (RIPK3) is an activator of necroptotic cell death, but recent work has implicated additional roles for RIPK3 in inflammatory signaling independent of cell death.
Daniels, Brian P. +9 more
core +1 more source
Small Molecule Fluorescent Ligands for the Atypical Chemokine Receptor 3 (ACKR3)
ACS Medicinal Chemistry Letters, 2023 The atypical chemokine receptor 3 (ACKR3) is a receptor that induces cancer progression and metastasis in multiple cell types. Therefore, new chemical tools are required to study the role of ACKR3 in cancer and other diseases. In this study, fluorescent probes, based on a series of small molecule ACKR3 agonists, were synthesized.
Dekkers, Sebastian +12 more
openaire +2 more sources