Results 81 to 90 of about 15,625 (221)

miRNAs as Influencers of Cell-Cell Communication in Tumor Microenvironment [PDF]

, 2020
microRNAs (miRNAs) are small noncoding RNAs that regulate gene expression at the posttranscriptional level, inducing the degradation of the target mRNA or translational repression.
Conti, Ilaria, Laface, Ilaria, Milani, Daniela, Neri, Luca M, Rimondi, Erika, Simioni, Carolina, Varano, Gabriele   +6 more
core   +1 more source

Early adversity and the comorbidity between metabolic disease and psychopathology

The Journal of Physiology, EarlyView.
Abstract figure legend Hierarchical diagram representing the interplay between the genetic background and early life adversities and its effect on multiple physiological processes that ultimately impact on the risk for the comorbdity between psychopathology and cardiometabolic disorders.
Ameyalli Gómez‐Ilescas, Patricia Pelufo Silveira   +1 more
wiley   +1 more source

Mouse vascularized adipose spheroids: an organotypic model for thermogenic adipocytes

Frontiers in Endocrinology
Adipose tissues, particularly beige and brown adipose tissue, play crucial roles in energy metabolism. Brown adipose tissues’ thermogenic capacity and the appearance of beige cells within white adipose tissue have spurred interest in their metabolic ...
Laura Ingeborg Davidsen, Carolina E. Hagberg, Victor Goitea, Victor Goitea, Stine Meinild Lundby, Steen Larsen, Morten Frendø Ebbesen, Natasha Stanic, Hande Topel, Hande Topel, Jan-Wilhelm Kornfeld, Jan-Wilhelm Kornfeld   +11 more
doaj   +1 more source

Functional Implications of DNA Methylation in Adipose Biology. [PDF]

, 2019
The twin epidemics of obesity and type 2 diabetes (T2D) are a serious health, social, and economic issue. The dysregulation of adipose tissue biology is central to the development of these two metabolic disorders, as adipose tissue plays a pivotal role ...
Kang, Sona, Ma, Xiang
core  

Targeting Adipose Tissue Function Protects Against Heart Failure with Preserved Ejection Fraction

Advanced Science, Volume 13, Issue 7, 3 February 2026.
This study explores the role adipose tissue (AT) phenotypes have in determining cardiovascular outcomes in an obesity‐related heart failure with preserved ejection fraction (HFpEF) model. Pharmacological induction of thermogenesis promoted resilience to HFpEF‐induced remodeling of AT and conferred cardioprotection. Surgical and genetic models confirmed
Jordan Jousma, Zhenbo Han, Jooman Park, Gege Yan, Sen Zhang, Youjeong Kwon, Sarath Babu Nukala, Jindpreet Kandola, Sandra Pinho, Chong Wee Liew, Yuwei Jiang, Sang‐Ging Ong   +11 more
wiley   +1 more source

Beiging of perivascular adipose tissue regulates its inflammation and vascular remodeling

Nature Communications, 2022
AbstractAlthough inflammation plays critical roles in the development of atherosclerosis, its regulatory mechanisms remain incompletely understood. Perivascular adipose tissue (PVAT) has been reported to undergo inflammatory changes in response to vascular injury.
Yusuke Adachi, Kazutaka Ueda, Seitaro Nomura, Kaoru Ito, Manami Katoh, Mikako Katagiri, Shintaro Yamada, Masaki Hashimoto, Bowen Zhai, Genri Numata, Akira Otani, Munetoshi Hinata, Yuta Hiraike, Hironori Waki, Norifumi Takeda, Hiroyuki Morita, Tetsuo Ushiku, Toshimasa Yamauchi, Eiki Takimoto, Issei Komuro   +19 more
openaire   +3 more sources

Mitochondrial lipoylation integrates age-associated decline in brown fat thermogenesis. [PDF]

, 2019
Thermogenesis in brown adipose tissue (BAT) declines with age; however, what regulates this process remains poorly understood. Here, we identify mitochondria lipoylation as a previously unappreciated molecular hallmark of aged BAT in mice.
Chang, Chih-Hsiang, Chang, Hsin-Yi, Ikeda, Kenji, Ishihama, Yasushi, Jun, Heejin, Kajimura, Shingo, Oguri, Yasuo, Tajima, Kazuki, Wu, Jun, Yoneshiro, Takeshi   +9 more
core  

Tissue‐Specific Extracellular Vesicles Enriched From Circulation: Exploring the Liquid Biopsy Perspective

Journal of Extracellular Biology, Volume 5, Issue 2, February 2026.
ABSTRACT Extracellular vesicles (EVs) released from tissues can be found in human biofluids. EVs reflect the phenotypic state of their cell of origin, carrying informative molecular biomarkers within and between tissues, and represent a promising target for liquid biopsy.
Biancamaria Pierri, Erez Eitan, Kenneth W. Witwer, Diane B. Re, Andrea A. Baccarelli, Haotian Wu   +5 more
wiley   +1 more source

Discoidin domain receptor 1-deletion ameliorates fibrosis and promotes adipose tissue beiging, brown fat activity, and increased metabolic rate in a mouse model of cardiometabolic disease

Molecular Metabolism, 2020
Objective: Discoidin domain receptor 1 (DDR1) is a collagen binding receptor tyrosine kinase implicated in atherosclerosis, fibrosis, and cancer. Our previous research showed that DDR1 could regulate smooth muscle cell trans-differentiation, fibrosis and
Marsel Lino, David Ngai, Alison Liu, Amanda Mohabeer, Cameron Harper, Laura-lee Caruso, Stephanie A. Schroer, Fred Fu, Trevor McKee, Adria Giacca, Minna Woo, Michelle P. Bendeck   +11 more
doaj   +1 more source

Age-dependent Pdgfrβ signaling drives adipocyte progenitor dysfunction to alter the beige adipogenic niche in male mice

Nature Communications, 2023
Thermogenic beige fat can reduce fat mass and improve metabolic health, yet the ability to form beige fat rapidly declines with age. Here, the authors show that targeting the age-related ramping of Pdgfrβ signalling restores the ageing adipose tissue ...
Abigail M. Benvie, Derek Lee, Benjamin M. Steiner, Siwen Xue, Yuwei Jiang, Daniel C. Berry   +5 more
doaj   +1 more source