Results 11 to 20 of about 32,816 (310)
Thermal Stability of Amorphous Solid Dispersions [PDF]
Molecules, 2021 Amorphous solid dispersion drug delivery systems (ASD DDS) were proved to be efficient for the enhancement of solubility and bioavailability of poorly water-soluble drugs.
Dijana Jelić
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Pharmaceutics, 2021 Presently, a large number of drug molecules in development are BCS class II or IV compounds with poor aqueous solubility. Various novel solubilization techniques have been used to enhance drug solubility.
Yongjun Li +3 more
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Tailoring supersaturation from amorphous solid dispersions [PDF]
Journal of Controlled Release, 2018 The maximum achievable concentration of a drug in solution is dictated by the chemical potential of the solid form. Because an amorphous solid has a higher chemical potential than the corresponding crystal form, in the absence of phase transformations, a higher transient solubility is expected.
Na Li, Lynne S. Taylor
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Solubility improvement of progesterone from solid dispersions prepared by solvent evaporation and co-milling [PDF]
, 2020 The aim of this contribution was to evaluate the impact of processing methods and polymeric carriers on the physicochemical properties of solid dispersions of the poorly soluble drug progesterone (PG). Five polymers: hydroxypropyl methylcellulose (HPMC),
Al-Obaidi, Hisham +3 more
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Polymer/Amorphous Salt Solid Dispersions of Ciprofloxacin [PDF]
Pharmaceutical Research, 2017 To improve the pharmaceutical properties of amorphous ciprofloxacin (CIP) succinate salts via formulation as polymer/amorphous salt solid dispersions (ASSDs).ASSDs consisting of an amorphous CIP/succinic acid 1:1 or 2:1 salt dispersed in PVP or Soluplus were produced by spray drying and ball milling.
Hanah Mesallati, Lidia Tajber
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Automation potential of a new, rapid, microscopy based method for screening drug-polymer solubility [PDF]
, 2020 For the pharmaceutical industry, the preformulation screening of the compatibility of drug and polymeric excipients can often be time-consuming because of the use of trial-and-error approaches.
Alhijjaj, Muqdad +4 more
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The Stabilization of Amorphous Zopiclone in an Amorphous Solid Dispersion [PDF]
AAPS PharmSciTech, 2015 Zopiclone is a poorly soluble psychotherapeutic agent. The aim of this study was to prepare and characterize an amorphous form of zopiclone as well as the characterization and performance of a stable amorphous solid dispersion. The amorphous form was prepared by the well-known method of quench-cooling of the melt. The solid dispersion was prepared by a
Milne, Marnus +2 more
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Pharmaceutics, 2023 The prevalence of active pharmaceutical ingredients (APIs) with low water solubility has experienced a significant increase in recent years. These APIs present challenges in formulation, particularly for oral dosage forms, despite their considerable ...
Arif Budiman +8 more
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Antioxidants, 2021 In this study, we designed amorphous solid dispersions based on Eudragit E/HCl (neutralized Eudragit E using hydrochloric acid) to maximize the dissolution of trans-resveratrol.
Eun-Sol Ha +4 more
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Intermolecular interaction and solid state characterization of abietic acid/chitosan solid dispersions possessing antimicrobial and antioxidant properties [PDF]
, 2018 The aim of this work was to prepare and characterize solid dispersions of abietic acid (AB) and chitosan (CS) to investigate how formulation of the mixture may help in the battle against microbial colonization in different areas, such as the biomedical ...
Argent Richard, H. +6 more
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