Results 31 to 40 of about 32,816 (310)

Optimization and evaluation of resveratrol amorphous solid dispersions with a novel polymeric system

Mathematical Biosciences and Engineering, 2022
The preparation of amorphous solid dispersions using polymers is a commonly used formulation strategy for enhancing the solubility of poorly water-soluble drugs.
Gangqi Han, Bing Wang , Mengli Jia, Shuxin Ding , Wenxuan Qiu , Yuxuan Mi , Zhimei Mi, Yuhao Qin, Wenxing Zhu, Xinli Liu, Wei Li   +10 more
doaj   +1 more source

Processing-Induced Disorder in Pharmaceutical Materials [PDF]

, 2016
This chapter focuses on the major types of pharmaceutical processing methods that have been widely reported to produce disordered material either intentionally or unintentionally.
Al-Obaidi, Alkhatib, Alonzo, Bahl, Balani, Breitenbach, Brough, Brown, Cal, Cerea, Chakraborty, Chattoraj, Chieng, Clark, Cordeiro, Cui, De Beer, Descamps, DiNunzio, Dinunzio, El-Badry, Elamin, Felton, Feng, Forster, Gazzaniga, Graeser, Guns, Gupta, He, Hu, Hu, Janssens, Kang, Karmwar, Ke, Keen, Khan, Kim, Koivisto, Lai, Laitinen, Laitinen, Lang, Lauer, Luisi, Luo, Löbmann, Löbmann, Nagy, Ng, Norrman, Otte, Otte, Passerini, Patterson, Porter, Qi, Qi, Qi, Qi, Repka, Riippi, Saerens, Sammoura, Santivarangkna, Sauer, Sauer, Sill, Sollohub, Tang, Trasi, Trasi, Van den Brande, Van Eerdenbrugh, Van Eerdenbrughand, Van Melkebeke, Vehring, Weatherley, Weuts, Willart, Willart, Willart, Williams, Windbergs, Windbergs, Wojnarowska, Yang, Zamani, Zema   +89 more
core   +1 more source

Myth or Truth: The Glass Forming Ability Class III Drugs Will Always Form Single-Phase Homogenous Amorphous Solid Dispersion Formulations

Pharmaceutics, 2019
The physical stability of amorphous solid dispersions (ASD) of active pharmaceutical ingredients (APIs) of high glass forming ability (GFA class III) is generally expected to be high among the scientific community.
Piyush Panini, Massimiliano Rampazzo, Abhishek Singh, Filip Vanhoutte, Guy Van den Mooter   +4 more
doaj   +1 more source

Design and Characterization of Phosphatidylcholine-Based Solid Dispersions of Aprepitant for Enhanced Solubility and Dissolution

Pharmaceutics, 2020
This study aimed to improve the solubility and dissolution of aprepitant, a drug with poor aqueous solubility, using a phosphatidylcholine (PC)-based solid dispersion system.
Sooho Yeo, Jieun An, Changhee Park, Dohyun Kim, Jaehwi Lee   +4 more
doaj   +1 more source

Co-Amorphous Solid Dispersions for Solubility and Absorption Improvement of Drugs: Composition, Preparation, Characterization and Formulations for Oral Delivery

Pharmaceutics, 2018
The amorphous solid state offers an improved apparent solubility and dissolution rate. However, due to thermodynamic instability and recrystallization tendencies during processing, storage and dissolution, their potential application is limited. For this
Anna Karagianni, Kyriakos Kachrimanis, Ioannis Nikolakakis   +2 more
doaj   +1 more source

Influence of pH on mechanical relaxations in high solids lm-pectin preparations [PDF]

, 2015
The influence of pH on the mechanical relaxation of LM-pectin in the presence of co-solute has been investigated by means of differential scanning calorimetry, ζ-potential measurements and small deformation dynamic oscillation in shear.
Al-Ruqaie, Alba, Alba, Almrhag, Behrouzian, Bohmer, Espitia, Evageliou, Evageliou, Fathi, Ferry, Ghori, Grimm, Haines, Hansen, Jiang, K. Alba, Kasapis, Kasapis, Kasapis, Kasapis, Kasapis, Kasapis, Kim, Kontogiorgos, Mezger, Mohammad Amini, Ngai, Panyoyai, Richardson, Rincon, Rodriguez-Rivero, Roland, S. Kasapis, Sengkhamparn, Sengkhamparn, Strom, Strom, Tschoegl, V. Kontogiorgos, Vincken, Wendlandt, Williams   +42 more
core   +1 more source

Characterization of heterogeneity and spatial distribution of phases in complex solid dispersions by thermal analysis by structural characterization and X-ray micro computed tomography [PDF]

, 2016
Purpose: This study investigated the effect of drug-excipient miscibility on the heterogeneity and spatial distribution of phase separation in pharmaceutical solid dispersions at a micron-scale using two novel and complementary characterization ...
Alhijjaj, Muqdad, Belton, Peter, Qi, Sheng, Reading, Mike, Yassin, Samy, Zeitler, J. Axel   +5 more
core   +1 more source

Use of Solid Dispersion Systems in Pharmacy

Конденсированные среды и межфазные границы, 2020
An overview of the use of solid dispersion systems in pharmacy is presented. The main techniques of obtaining solid dispersions were considered. The simplest one is the solvent removal technique: the medicinal drug and the carrier are dissolved in the ...
Sof ’ya Yu. Silaeva, Alena S. Belenova, Aleksey I. Slivkin, Elena E. Chupandina, Savva R. Naryshkin, Ivan I. Krasnyuk (Jr.), Ivan I. Krasnyuk   +6 more
doaj   +1 more source

Superiority of Mesoporous Silica-Based Amorphous Formulations over Spray-Dried Solid Dispersions

Pharmaceutics, 2022
The aim of this study was to compare the performance of two amorphous formulation strategies: mesoporous silica via solvent impregnation, and solid dispersions by spray drying. Poorly soluble fenofibrate was chosen as the model drug compound.
Hongwei Zhang, Minglu Li, Jianmin Li, Anjali Agrawal, Ho-Wah Hui, Demin Liu   +5 more
doaj   +1 more source

Direct numerical simulations for non-Newtonian rheology of concentrated particle dispersions [PDF]

, 2009
The non-Newtonian behavior of a monodisperse concentrated dispersion of spherical particles was investigated using a direct numerical simulation method, that takes into account hydrodynamic interactions and thermal fluctuations accurately.
A. Einstein, R. G. Larson, Ryoichi Yamamoto, Takuya Iwashita, W. B. Russel   +4 more
core   +1 more source