Results 41 to 50 of about 5,344 (155)
Acta Neuropathologica Communications, 2018 After spinal cord injury (SCI), neutrophil elastase (NE) released at injury site disrupts vascular endothelium integrity and stabilization. Angiopoietins (ANGPTs) are vascular growth factors that play an important role in vascular stabilization.
Hemant Kumar +13 more
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Dysregulation of angiopoietins is associated with placental malaria and low birth weight. [PDF]
PLoS ONE, 2010 Placental malaria (PM) is associated with adverse pregnancy outcomes including low birth weight (LBW). However, the precise mechanisms by which PM induces LBW are poorly defined.
Karlee L Silver +4 more
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World Journal of Surgical Oncology, 2019 Background Tumor escape mechanisms mediated in the tumor microenvironment can significantly reduce the capacity of the anti-tumor function of the immune system. TIE2-expressing monocytes (TEMs), related angiopoietins, and tumor necrosis are considered to
Georgi Atanasov +8 more
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Angiopoietins modulate endothelial adaptation, glomerular and podocyte hypertrophy after uninephrectomy. [PDF]
PLoS ONE, 2013 Glomerular capillary remodeling is an essential process in the development of glomerular hypertrophy. Angiopoietins, which are important regulators in angiogenesis, plays a role in the development of glomerulus during embryogenesis.
Wen Chih Chiang +11 more
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Journal of the American College of Cardiology, 2004 The goal of this research was to test the hypothesis that plasma angiopoietin (Ang-1), its soluble receptor tie-2, and Ang-2 levels would be abnormal in patients with acute and chronic congestive heart failure (CHF) when compared with healthy controls.Increased plasma vascular endothelial growth factor (VEGF) in CHF is suggestive of excess angiogenesis-
Chong, Aun Yeong +4 more
openaire +2 more sources
Role of Angiopoietins and Tie-2 in Diabetic Retinopathy
Electronic Physician, 2017 Objective: The aim of this study was to determine the serum levels of angiopoietin-1 (Ang-1), angiopoietin-2 (Ang-2), soluble vascular endothelial tyrosine kinase receptor (Tie-2) and vascular endothelial growth factor (VEGF), in the serum of type 2 ...
Nervana Khalaf +5 more
doaj +1 more source
New Insights into the Pro-Inflammatory Activities of Ang1 on Neutrophils: Induction of MIP-1β Synthesis and Release. [PDF]
PLoS ONE, 2016 We reported the expression of angiopoietin Tie2 receptor on human neutrophils and the capacity of angiopoietins (Ang1 and Ang2) to induce pro-inflammatory activities, such as platelet-activating factor synthesis, β2-integrin activation and neutrophil ...
Elizabeth Dumas +4 more
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The yin, the yang, and the Angiopoietin-1 [PDF]
Journal of Clinical Investigation, 2011 Twenty years after the discovery of the vascular endothelial Tie receptor tyrosine kinases and 15 years after the discovery of the Tie2 ligand, angiopoietin-1 (Angpt1, also known as Ang1), a study published in the current issue of the JCI reveals an unexpected loss-of-function phenotype of mice conditionally deleted of the Angpt1 gene.
Alitalo Kari +3 more
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Cervical cancer cell–derived angiopoietins promote tumor progression
Tumor Biology, 2017 Metastatic or recurrent cervical cancer has limited treatment options and a high rate of mortality. Although anti-vascular endothelial growth factor drugs have shown great promise as a therapeutic target for treatment of advanced cervical cancer, drug ...
Ping Yang +9 more
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The curse of angiopoietin-2 in ARDS: on stranger TI(E)des
Critical Care, 2018 Pulmonary inflammation and vascular leakage are hallmarks of acute respiratory distress syndrome (ARDS), a life-threatening condition, for which there is no specific pharmacologic treatment.
Philipp Kümpers, Alexander Lukasz
doaj +1 more source