Results 21 to 30 of about 5,344 (155)
Biological characterization of angiopoietin‐3 and angiopoietin‐4
The FASEB Journal, 2004 ABSTRACT The angiopoietin (Ang) family of growth factors includes Ang1, Ang2, Ang3, and Ang4, all of which bind to the endothelial receptor tyrosine kinase Tie2. Ang3 (mouse) and Ang4 (human) are interspecies orthologs.
Lee, HJ +9 more
+8 more sources
Anti-angiogenic Targets: Angiopoietin and Angiopoietin Receptors [PDF]
, 2017 Tumor blood vessel formation (angiogenesis) is essential for tumor growth and metastasis. Two main endothelial ligand–receptor pathways regulating angiogenesis are vascular endothelial growth factor (VEGF) receptor and angiopoietin-TIE receptor pathways.
Kiss, Elina A., Saharinen, Pipsa
openaire +1 more source
Angiopoietin-1/Angiopoietin-2 Ratio for Prediction of Preeclampsia [PDF]
American Journal of Hypertension, 2009 A number of different biophysical and biochemical markers have been proposed as predictors of preeclampsia. Factors involved in the angiogenic balance are suggested as candidate markers. The purpose of this prospective, longitudinal cohort study was to determine whether a ratio between Angiopoietin-1 (Ang-1) and Angiopoietin-2 (Ang-2) can be used to ...
Marie, Bolin +6 more
openaire +2 more sources
Cooperation of Angiopoietin-2 and Angiopoietin-4 in Schlemm's Canal Maintenance
Investigative Opthalmology & Visual Science, 2022 Defects in the iridocorneal angle tissues, including the trabecular meshwork (TM) and Schlemm's canal (SC), impair aqueous humor flow and increase the intraocular pressure (IOP), eventually resulting in glaucoma. Activation of endothelial tyrosine kinase receptor Tie2 by angiopoietin-1 (Angpt1) has been demonstrated to be essential for SC formation ...
Kapiainen, E. (Emmi) +4 more
openaire +3 more sources
Impact of Angiopoietin-2 on Kidney Diseases
Kidney Diseases, 2023 Background: Angiopoietins (Ang) are essential angiogenic factors involved in angiogenesis, vascular maturation, and inflammation. The most studied angiopoietins, angiopoietin-1 (Ang-1) and angiopoietin-2 (Ang-2), behave antagonistically to each other in ...
Mei Li +6 more
doaj +1 more source
Is There a Role for Basophils in Cancer?
Frontiers in Immunology, 2020 Basophils were identified in human peripheral blood by Paul Ehrlich over 140 years ago. Human basophils represent <1% of peripheral blood leukocytes.
Giancarlo Marone +18 more
doaj +1 more source
The misunderstood link between SARS-CoV-2 and angiogenesis. A narrative review
Pulmonology, 2023 Novel Coronavirus Disease 2019 (Covid-19) is associated with multi-systemic derangement, including circulatory dysfunction with features of endothelial dysfunction, microangiopathic thrombosis and angiocentric inflammation.
G. Madureira, R. Soares
doaj +1 more source
Angiopoietins stimulate pancreatic islet development from stem cells
Scientific Reports, 2021 In vitro differentiation of human induced pluripotent stem cells (iPSCs) into functional islets holds immense potential to create an unlimited source of islets for diabetes research and treatment.
Soujanya S. Karanth +4 more
doaj +1 more source
The Complex Role of Angiopoietin-2 in the Angiopoietin-Tie Signaling Pathway [PDF]
Cold Spring Harbor Perspectives in Medicine, 2012 The angiopoietin-Tie signaling system is a vascular-specific receptor tyrosine kinase pathway that is essential for normal vascular development. Although the basic functioning of the pathway is understood, many uncertainties remain about the role of certain members of the pathway, particularly angiopoietin-2 (Ang2), in pathological vascular remodeling ...
Gavin, Thurston, Christopher, Daly
openaire +2 more sources
Endothelial Activation: The Ang/Tie Axis in Sepsis
Frontiers in Immunology, 2018 Sepsis, a dysregulated host response to infection that causes life-threatening organ dysfunction, is a highly heterogeneous syndrome with no specific treatment.
Aleksandra Leligdowicz +4 more
doaj +1 more source