Results 31 to 40 of about 6,404 (202)

Angiopoietins stimulate pancreatic islet development from stem cells

Scientific Reports, 2021
In vitro differentiation of human induced pluripotent stem cells (iPSCs) into functional islets holds immense potential to create an unlimited source of islets for diabetes research and treatment.
Soujanya S. Karanth, Shuofei Sun, Huanjing Bi, Kaiming Ye, Sha Jin   +4 more
doaj   +1 more source

Secreted Phospholipases A2 in Hereditary Angioedema With C1-Inhibitor Deficiency

Frontiers in Immunology, 2018
BackgroundHereditary angioedema (HAE) caused by deficiency (type I) or dysfunction (type II) of the C1 inhibitor protein (C1-INH-HAE) is a disabling, potentially fatal condition characterized by recurrent episodes of swelling. We have recently found that
Stefania Loffredo, Anne Lise Ferrara, Maria Bova, Francesco Borriello, Francesco Borriello, Chiara Suffritti, Nóra Veszeli, Angelica Petraroli, Maria Rosaria Galdiero, Gilda Varricchi, Francescopaolo Granata, Andrea Zanichelli, Henriette Farkas, Marco Cicardi, Gérard Lambeau, Gianni Marone, Gianni Marone   +16 more
doaj   +1 more source

Targeting the PI3K/Akt Signaling Pathway: A Promising Therapeutic Strategy to Reduce Cancer Mortality and Overcome Chemoresistance. [PDF]

Health Sci Rep
ABSTRACT Background and Aims The phosphatidylinositol 3‐kinase (PI3K)/Akt signaling pathway is a central regulator of cellular properties that are essential for cancer progression, including cellular growth, survival, metabolism, and angiogenesis. Dysregulated PI3K/Akt signaling, often caused by genetic alterations in PIK3CA, loss of PTEN, or the ...
Mohiuddin M.
europepmc   +2 more sources

Fusogenic RNA Nanomodules for Fusion‐Mediated and Multiplexed siRNA Delivery

Advanced Functional Materials, EarlyView.
A fusogenic lipid‐layered RNA nanomodules (L‐CRAMs) enable high‐capacity and long‐lasting siRNA delivery through membrane fusion. These nanomodules carry exceptionally large siRNA payloads, avoid conventional endosomal uptake, and release multiple functional siRNAs through Dicer‐mediated processing.
Sunghyun Moon, Iksoo Jang, Taehyeon Kim, Nayoung Yoon, Kyuha Yum, Jong Bum Lee   +5 more
wiley   +1 more source

Altered Expression of Angiogenic Biomarkers in Pregnancy Associated with Gestational Diabetes

International Journal of General Medicine, 2021
Ebtisam Al-Ofi,1 Aziza Alrafiah,2 Salman Maidi,2 Safa Almaghrabi,1 Nora Hakami2 1Department of Physiology, Faculty of Medicine, King AbdulAziz University, Jeddah, Saudi Arabia; 2Department of Medical Laboratory Technology, Faculty of Applied Medical ...
Al-Ofi E, Alrafiah A, Maidi S, Almaghrabi S, Hakami N   +4 more
doaj  

Co‐Delivery of Sustained Release Chondroitinase ABC‐37 With Human iPSC‐Derived Neural Progenitors Promotes Transplant Survival and Functional Recovery in a Rodent Model of Stroke

Advanced Science, EarlyView.
A regenerative strategy for stroke combines human stem cell–derived neural progenitor cells with sustained release of a matrix‐modifying, thermostable chondroitinase ABC‐37 enzyme. In a rat model of stroke, co‐delivery enhanced transplanted cell survival and neuronal differentiation, degraded inhibitory extracellular matrix components, and improved ...
Nitzan Letko Khait, David Xinzheyang Li, Keyi Guo, Hong Cui, Quinton Sirianni, Dhana Abdo, Cindi M. Morshead, Molly S. Shoichet   +7 more
wiley   +1 more source

Role of angiopoietins in mesothelioma progression.

, 2018
Background and objective: Anti-angiogenic treatment has been recently shown to be clinically beneficial for mesothelioma patients. Angiopoietins-1 and -2 are key regulators of tumor angiogenesis.
Spella, M., Vazakidou, M.E., Kollintza, A., Stathopoulos, G.T., Moschos, C., Pappas, A., Kalomenidis, I., Magkouta, S., Skianis, I.   +8 more
core   +1 more source

Evaluation of Angiopoietins and Cell-Derived Microparticles after Stem Cell Transplantation [PDF]

, 2008
Although stem cell transplantation (SCT) is being used for hematopoietic reconstitution following high-dose chemotherapy for malignancy, it involves certain serious transplant-related complications such as graft-versus-host disease (GVHD).
Nomura, Shosaku, Yoshihara, Takao, Shosaku Nomura, Uoshima, Nobuhiko, Yutaka Kimura, Kimura, Yutaka, Yasuhiro Maeda, Ishii, Kazuyoshi, Ishida, Hiroyuki, Norihito Inami, Takao Yoshihara, Inami, Norihito, Hayashi, Kunio, Kazuyoshi Ishii, Fumiaki Urase, Hiroyuki Ishida, Kunio Hayashi, Nobuhiko Uoshima, Urase, Fumiaki, Maeda, Yasuhiro   +19 more
core   +1 more source

Association between macular vessel density and microvascular biomarkers in pediatric chronic kidney disease

Journal of the Egyptian Ophthalmological Society
Purpose This study evaluated retinal microvasculature changes in children with chronic kidney disease (CKD) using optical coherence tomography angiography (OCTA).
Engy R. Mohamed, Samira Z. Sayed, Lamia H. Ali, Mohamed Tarek A. Moustafa, Mohamed H. Mahgoob   +4 more
doaj   +1 more source

ANGPTL4 Exacerbates Renal Injury in Diabetic Kidney Disease by Impairing Podocyte Lipophagy via Compromised Lysosomal Degradative Function

Advanced Science, EarlyView.
In diabetic kidney disease, elevated podocyte ANGPTL4 is linked to reduced TFEB nuclear localization and compromised lysosomal degradative function. These changes impair podocyte lipophagy and promote lipid‐droplet accumulation and podocyte injury, which may contribute to renal injury progression.
Xiaojing Liu, Shimin Jiang, Zhenkun Yang, Shunlai Shang, Jiayi Li, Guming Zou, Cheng Zhou, Wenge Li   +7 more
wiley   +1 more source