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An Artificial Imine Reductase based on the Ribonuclease S Scaffold
ChemCatChem, 2014AbstractDative anchoring of a piano‐stool complex within ribonuclease S resulted in an artificial imine reductase. The catalytic performance was modulated upon variation of the coordinating amino acid residues in the S‐peptide. Binding of Cp*Ir (Cp*=C5Me5) to the native active site resulted in good conversions and moderate enantiomeric excess values ...
Maika Genz +6 more
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Sequence Selective Artificial Ribonucleases Employing Metal Ions As Scissors
2004Sequence-selective scission of RNA has been attracting interests of chemists and biochemists, since it is essential for molecular biology and therapy. If only one RNA can be chosen from many other RNAs and selectively cleaved at the desired site, it opens the way to new RNA science (regulation of expression of a specific gene in cells, advanced therapy,
A. Kuzuya, R. Mizoguchi, M. Komiyama
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ChemInform Abstract: A Method for Synthesis of an Artificial Ribonuclease
ChemInform, 2001AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Hans Aastroem, Roger Stroemberg
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Molecular design of artificial hydrolytic nucleases and ribonucleases.
Nucleic acids symposium series, 1993Artificial nucleases and ribonucleases, which selectively hydrolyze the specific phosphodiester linkages in DNAs and RNAs, are prepared by the attachment of organic and inorganic catalysts to DNA oligomers as sequence-recognizing moieties. A hybrid of ethylenediamine and a 19-mer DNA selectively hydrolyzes tRNA(Phe) at the 3'-side of C63.
M, Komiyama +5 more
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Site-Specific Artificial Ribonucleases: Conjugates of Oligonucleotides with Catalytic Groups
2004Design of site-specific artificial ribonucleases is one of the most challenging tasks in RNA targeting (Morrow 1994; Haner et aL 1998; Oivanen et aL 1998; Sil’nikov and Vlassov 2001). Apart from being useful molecular biology tools (Huber 1993; Giege et aL 2000), such compounds may provide new opportunities for design of therapeutics targeting specific
M. A. Zenkova, N. G. Beloglazova
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Artificially induced microheterogeneity in ribonuclease
Biochemical and Biophysical Research Communications, 1960R, SHAPIRA, S, PARKER
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Acetylacetonato-lanthanide complexes as eminent catalytic sites for artificial ribonucleases.
Nucleic acids symposium series, 1996Acetylacetonato complexes of lutetium, ytterbium, thulium, and europium ions efficiently hydrolyze the phosphodiester linkage in adenylyl(3'-5')adenosine. The pseudo first-order rate constant (3.2 x 10(-2) h-1) at pH 7.2 and 30 degrees C for the 1:1 lutetium-acetylacetonato complex (0.5 mmol dm-3) is close to the value (3.5 x 10(-2) h-1) for free ...
J, Sumaoka, H, Uchida, M, Komiyama
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Predicting cancer outcomes with radiomics and artificial intelligence in radiology
Nature Reviews Clinical Oncology, 2021Kaustav Bera +2 more
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Artificial channels for confined mass transport at the sub-nanometre scale
Nature Reviews Materials, 2021Jie Shen, Gong-Ping Liu, Yu Han
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