Results 1 to 10 of about 1,731 (136)
FBB18 participates in preassembly of almost all axonemal dyneins independent of R2TP complex. [PDF]
PLoS Genetics, 2022 Assembly of dynein arms requires cytoplasmic processes which are mediated by dynein preassembly factors (DNAAFs). CFAP298, which is conserved in organisms with motile cilia, is required for assembly of dynein arms but with obscure mechanisms.
Limei Wang +3 more
doaj +2 more sources
Functional partitioning of a liquid-like organelle during assembly of axonemal dyneins [PDF]
eLife, 2020 Ciliary motility is driven by axonemal dyneins that are assembled in the cytoplasm before deployment to cilia. Motile ciliopathy can result from defects in the dyneins themselves or from defects in factors required for their cytoplasmic pre-assembly ...
Chanjae Lee +8 more
doaj +2 more sources
Structure of a microtubule-bound axonemal dynein [PDF]
Nature Communications, 2021 Axonemal dyneins are tethered to doublet microtubules inside cilia to drive ciliary beating but the mechanisms regulating their localization and function are poorly understood.
Travis Walton, Hao Wu, Alan Brown
doaj +3 more sources
Post-LECA Origin and Diversification of an Axonemal Outer Arm Dynein Motor. [PDF]
Cytoskeleton (Hoboken)ABSTRACT Dyneins were present in the last eukaryotic common ancestor (LECA) and play key roles in eukaryotic biology. Axonemal dyneins form the inner and outer arms that power ciliary beating, and it has long been recognized that outer arms in some organisms contain two different heavy chain motors, whereas those from other species contain a third unit
King SM.
europepmc +2 more sources
Structure and Function of Dynein’s Non-Catalytic Subunits [PDF]
CellsDynein, an ancient microtubule-based motor protein, performs diverse cellular functions in nearly all eukaryotic cells, with the exception of land plants.
Lu Rao, Arne Gennerich
doaj +2 more sources
TRiC Is a Structural Component of Mammalian Sperm Axonemes. [PDF]
Cytoskeleton (Hoboken)ABSTRACT The TRiC chaperonin is responsible for folding ~5%–10% of the proteome in eukaryotic cells. Our recent cryo‐electron microscopy studies of axonemes from diverse mammalian cell types led to the surprising discovery that a fully assembled TRiC chaperonin is a structural component of mammalian sperm flagella, where it is tethered to the radial ...
Brown A +3 more
europepmc +2 more sources
Torque generating properties of Tetrahymena ciliary three-headed outer-arm dynein
Scientific Reports, 2022 Eukaryotic cilia/flagella are cellular bio-machines that drive the movement of microorganisms. Molecular motor axonemal dyneins in the axoneme, which consist of an 9 + 2 arrangement of microtubules, play an essential role in ciliary beating.
Shin Yamaguchi +2 more
doaj +1 more source
Oscillatory movement of a dynein-microtubule complex crosslinked with DNA origami
eLife, 2022 Bending of cilia and flagella occurs when axonemal dynein molecules on one side of the axoneme produce force and move toward the microtubule (MT) minus end.
Shimaa A Abdellatef +10 more
doaj +1 more source
Cytoplasmic factories for axonemal dynein assembly [PDF]
Journal of Cell Science, 2021 ABSTRACT Axonemal dyneins power the beating of motile cilia and flagella. These massive multimeric motor complexes are assembled in the cytoplasm, and subsequently trafficked to cilia and incorporated into the axonemal superstructure. Numerous cytoplasmic factors are required for the dynein assembly process, and, in mammals, defects lead
openaire +2 more sources