Results 11 to 20 of about 1,751 (156)

Three-dimensional structure of the Trypanosome flagellum suggests that the paraflagellar rod functions as a biomechanical spring. [PDF]

PLoS ONE, 2012
Flagellum motility is critical for normal human development and for transmission of pathogenic protozoa that cause tremendous human suffering worldwide.
Louise C Hughes, Katherine S Ralston, Kent L Hill, Z Hong Zhou   +3 more
doaj   +1 more source

Regulation of motor activity of ciliary outer-arm dynein by the light chain 1; Implications from the structure of the light chain bound to the microtubule-binding domain of the heavy chain

Biophysics and Physicobiology, 2023
Ciliary bending movements are powered by motor protein axonemal dyneins. They are largely classified into two groups, inner-arm dynein and outer-arm dynein. Outer-arm dynein, which is important for the elevation of ciliary beat frequency, has three heavy
Toshiki Yagi, Akiyuki Toda, Muneyoshi Ichikawa, Genji Kurisu   +3 more
doaj   +1 more source

N-Terminal Processing and Modification of Ciliary Dyneins

Cells, 2023
Axonemal dyneins are highly complex microtubule motors that power ciliary motility. These multi-subunit enzymes are assembled at dedicated sites within the cytoplasm.
Miho Sakato-Antoku, Jeremy L. Balsbaugh, Stephen M. King   +2 more
doaj   +1 more source

Nonlinear amplitude dynamics in flagellar beating [PDF]

Royal Society Open Science, 2017
The physical basis of flagellar and ciliary beating is a major problem in biology which is still far from completely understood. The fundamental cytoskeleton structure of cilia and flagella is the axoneme, a cylindrical array of microtubule doublets ...
David Oriola, Hermes Gadêlha, Jaume Casademunt   +2 more
doaj   +1 more source

Identification of new genes involved in human adipogenesis and fat storage. [PDF]

PLoS ONE, 2012
Since the worldwide increase in obesity represents a growing challenge for health care systems, new approaches are needed to effectively treat obesity and its associated diseases. One prerequisite for advances in this field is the identification of genes
Jörn Söhle, Nikolaus Machuy, Elma Smailbegovic, Ursula Holtzmann, Elke Grönniger, Horst Wenck, Franz Stäb, Marc Winnefeld   +7 more
doaj   +1 more source

Three-dimensional flagella structures from animals’ closest unicellular relatives, the Choanoflagellates

eLife, 2022
In most eukaryotic organisms, cilia and flagella perform a variety of life-sustaining roles related to environmental sensing and motility. Cryo-electron microscopy has provided considerable insight into the morphology and function of flagellar structures,
Justine M Pinskey, Adhya Lagisetty, Long Gui, Nhan Phan, Evan Reetz, Amirrasoul Tavakoli, Gang Fu, Daniela Nicastro   +7 more
doaj   +1 more source

Ccdc113/Ccdc96 complex, a novel regulator of ciliary beating that connects radial spoke 3 to dynein g and the nexin link.

PLoS Genetics, 2021
Ciliary beating requires the coordinated activity of numerous axonemal complexes. The protein composition and role of radial spokes (RS), nexin links (N-DRC) and dyneins (ODAs and IDAs) is well established.
Rafał Bazan, Adam Schröfel, Ewa Joachimiak, Martyna Poprzeczko, Gaia Pigino, Dorota Wloga   +5 more
doaj   +1 more source

CFAP53 regulates mammalian cilia-type motility patterns through differential localization and recruitment of axonemal dynein components.

PLoS Genetics, 2020
Motile cilia can beat with distinct patterns, but how motility variations are regulated remain obscure. Here, we have studied the role of the coiled-coil protein CFAP53 in the motility of different cilia-types in the mouse.
Takahiro Ide, Wang Kyaw Twan, Hao Lu, Yayoi Ikawa, Lin-Xenia Lim, Nicole Henninger, Hiromi Nishimura, Katsuyoshi Takaoka, Vijay Narasimhan, Xiumin Yan, Hidetaka Shiratori, Sudipto Roy, Hiroshi Hamada   +12 more
doaj   +1 more source

Space-dependent formation of central pair microtubules and their interactions with radial spokes. [PDF]

PLoS ONE, 2014
Cilia and flagella contain nine outer doublet microtubules and a pair of central microtubules. The central pair of microtubules (CP) is important for cilia/flagella beating, as clearly shown by primary ciliary dyskinesia resulting from the loss of the CP.
Yuki Nakazawa, Tetsuro Ariyoshi, Akira Noga, Ritsu Kamiya, Masafumi Hirono   +4 more
doaj   +1 more source

Systematic studies of all PIH proteins in zebrafish reveal their distinct roles in axonemal dynein assembly

eLife, 2018
Construction of motile cilia/flagella requires cytoplasmic preassembly of axonemal dyneins before transport into cilia. Axonemal dyneins have various subtypes, but the roles of each dynein subtype and their assembly processes remain elusive in ...
Hiroshi Yamaguchi, Toshiyuki Oda, Masahide Kikkawa, Hiroyuki Takeda   +3 more
doaj   +1 more source