Results 21 to 30 of about 1,751 (156)
Cold Spring Harbor Perspectives in Biology, 2016 Axonemal dyneins form the inner and outer rows of arms associated with the doublet microtubules of motile cilia. These enzymes convert the chemical energy released from adenosine triphosphate (ATP) hydrolysis into mechanical work by causing the doublets to slide with respect to each other.
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Cryo-EM of dynein microtubule-binding domains shows how an axonemal dynein distorts the microtubule
eLife, 2019 Dyneins are motor proteins responsible for transport in the cytoplasm and the beating of axonemes in cilia and flagella. They bind and release microtubules via a compact microtubule-binding domain (MTBD) at the end of a coiled-coil stalk.
Samuel E Lacey +3 more
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Trypanin, a component of the flagellar Dynein regulatory complex, is essential in bloodstream form African trypanosomes. [PDF]
PLoS Pathogens, 2006 The Trypanosoma brucei flagellum is a multifunctional organelle with critical roles in motility, cellular morphogenesis, and cell division. Although motility is thought to be important throughout the trypanosome lifecycle, most studies of flagellum ...
Katherine S Ralston, Kent L Hill
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Torque Generation by Axonemal Outer-Arm Dynein [PDF]
Biophysical Journal, 2015 Outer-arm dynein is the main engine providing the motive force in cilia. Using three-dimensional tracking microscopy, we found that contrary to previous reports Tetrahymena ciliary three-headed outer-arm dynein (αβγ) as well as proteolytically generated two-headed (βγ) and one-headed (α) subparticles showed clockwise rotation of each sliding ...
Yamaguchi, Shin +5 more
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Ciliary Motility: Regulation of Axonemal Dynein Motors [PDF]
Cold Spring Harbor Perspectives in Biology, 2017 Ciliary motility is crucial for the development and health of many organisms. Motility depends on the coordinated activity of multiple dynein motors arranged in a precise pattern on the outer doublet microtubules. Although significant progress has been made in elucidating the composition and organization of the dyneins, a comprehensive understanding of
Rasagnya, Viswanadha +2 more
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A liquid-like organelle at the root of motile ciliopathy
eLife, 2018 Motile ciliopathies are characterized by specific defects in cilia beating that result in chronic airway disease, subfertility, ectopic pregnancy, and hydrocephalus.
Ryan L Huizar +7 more
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Inner lumen proteins stabilize doublet microtubules in cilia and flagella
Nature Communications, 2019 Microtubules in cilia are sufficiently stable to withstand the beating motion, but how they are stabilized while serving as tracks for intraflagellar transport and axonemal dyneins remains unknown.
Mikito Owa +8 more
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Slow Axonemal Dynein e Facilitates the Motility of Faster Dynein c [PDF]
Biophysical Journal, 2014 We highly purified the Chlamydomonas inner-arm dyneins e and c, considered to be single-headed subspecies. These two dyneins reside side-by-side along the peripheral doublet microtubules of the flagellum. Electron microscopic observations and single particle analysis showed that the head domains of these two dyneins were similar, whereas the tail ...
Shimizu, Youské +3 more
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PLoS Genetics, 2020 Primary ciliary dyskinesia (PCD) is characterized by chronic airway disease, reduced fertility, and randomization of the left/right body axis. It is caused by defects of motile cilia and sperm flagella.
Ximena M Bustamante-Marin +13 more
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American Journal of Medical Genetics Part A, EarlyView.ABSTRACT The ciliopathies are a group of genetic disorders caused by defective function of either the primary cilia (a large number) or the motile cilia (a much smaller number). These have been defined as diseases with mutations in genes encoding individual ciliary or cilia‐associated proteins.
Robert P. Erickson +1 more
wiley +1 more source