Results 41 to 50 of about 1,751 (156)

Situs Inversus Totalis: A Case Report and Literature Review

Clinical Case Reports, Volume 14, Issue 2, February 2026.
ABSTRACT Situs Inversus Totalis (SIT) is a rare congenital anomaly characterized by the complete mirror‐image transposition of the thoracoabdominal viscera. Although typically it has a favorable prognosis, SIT can be associated with ciliopathy‐related disorders, most notably Primary Ciliary Dyskinesia (PCD).
Xin Du, Ning Wang, Juanjuan Sheng, Yunshan Zhang, Jinfang Gao   +4 more
wiley   +1 more source

Surgical Management of Kartagener's Syndrome With Bronchiectasis in a Pediatric Patient: A Case Report on Right Lower Lung Lobectomy in a 9‐Year‐Old Female

Clinical Case Reports, Volume 14, Issue 2, February 2026.
ABSTRACT Kartagner syndrome is a rare congenital autosomal recessive disorder of ciliary movement, characterized by triad of chronic sinusitis, situs inversus and bronchiectasis leading to recurrent chest and sinuses infections. The primary objectives of this case report is to highlight the presentation of this rare disorder, its surgical challenge ...
Pakeezah Tabasum, Makhdooom Bilawal, Priya Devi, Waseem Sajjad, Ali Raza Brohi, Mohammed Hammad Jaber Amin   +5 more
wiley   +1 more source

The absence of both RIBC1 and RIBC2 induces decreased sperm motility and litter size in male mice

Andrology, Volume 14, Issue 2, Page 545-554, February 2026.
Abstract Background RIBC1 (RIB43A domain with coiled‐coils 1) and RIBC2 (RIB43A domain with coiled‐coils 2) are homolog proteins of RIB43a which is localized to microtubules in the cilia and flagella of unicellular organisms. Cryo‐electron microscopy and artificial intelligence studies showed that RIBC1 and RIBC2 are microtubule inner proteins (MIPs ...
Kento Katsuma, Keisuke Shimada, Shingo Tonai, Daisuke Mashiko, Rie Iida‐Norita, Yuki Kaneda, Haruhiko Miyata, Masahito Ikawa   +7 more
wiley   +1 more source

Genetic differences between primary colorectal cancer and its paired synchronous and metachronous metastases

International Journal of Cancer, Volume 158, Issue 1, Page 120-130, 1 January 2026.
What's new? Colorectal cancer (CRC) frequently metastasizes to the liver, either synchronously with primary diagnosis or metachronously, after variable time intervals. Although implicated, the role of genetic factors in driving synchronous and metachronous disease progression remains uncertain.
Marie Rajtmajerova, Filip Ambrozkiewicz, Viktor Hlavac, Andriy Trailin, Lenka Cervenkova, Jan Bruha, Simona Susova, Pavel Soucek, Pavel Vodicka, Ludmila Vodickova, Ondrej Kubecek, Stanislav Filip, Venkata R. Mallela, Wenjing Ye, Frantisek Zitricky, Vaclav Liska, Kari Hemminki   +16 more
wiley   +1 more source

The Three Pillars of ATP Production in Mammalian Sperm: Integrating Gluconeogenesis Into the Metabolic Framework

Reproductive Medicine and Biology, Volume 25, Issue 1, January/December 2026.
ABSTRACT Purpose Mammalian sperm require a large amount of ATP to sustain motility. While glycolysis and oxidative phosphorylation (OXPHOS) are established ATP sources, they cannot fully explain motility maintenance under glucose‐deprived conditions.
Kosei Oishi, Reiji Tokito, Yasushi Yumura, Manabu Yoshida, Kaoru Yoshida, Masatsugu Asada, Koyuki Mikami, Hiroyuki Watanabe, Yuki Muranishi, Yasuyuki Kurihara   +9 more
wiley   +1 more source

Axonemal dynein assembly requires the R2TP complex component Pontin [PDF]

Development, 2017
Pontin (Ruvbl1) and Reptin (Ruvbl2) are closely related AAA ATPases. They are components of the Ruvbl1-Ruvbl2-Tah1-Pih1 (R2TP) complexes that function as co-chaperones for the assembly of multiple macromolecular protein complexes. Here, we show that Pontin is essential for cilia motility in both zebrafish and mouse and that Pontin and Reptin function ...
Yuanyuan Li, Lu Zhao, Shiaulou Yuan, Jiefang Zhang, Zhaoxia Sun   +4 more
openaire   +2 more sources

Identification of a Novel DNAAF3 Variant in a 54‐Year‐Old Patient With Newly Diagnosed Primary Ciliary Dyskinesia (PCD)

Case Reports in Genetics, Volume 2026, Issue 1, 2026.
Primary ciliary dyskinesia (PCD) is a rare and heterogeneous inherited disease characterized by impaired mucociliary clearance. Patients with PCD typically present with recurrent respiratory infections resulting in the development of bronchiectasis. Even though awareness of the disease has increased over the years, PCD remains underdiagnosed.
Mirja M. Wirtz, Sabine Ebner, Anna Pleyers, Natalie Firlei-Fleischmann, Richard Untersteiner, Michael Studnicka, Irfan Ahmad   +6 more
wiley   +1 more source

Immunostaining and Ciliary Movement Analysis in Primary Ciliary Dyskinesia With a Homozygous Deletion Involving Exons 1–4 of DRC1: A Case Report

Respirology Case Reports, Volume 13, Issue 12, December 2025.
We report the case of a 29‐year‐old male diagnosed with primary ciliary dyskinesia (PCD) with a homozygous loss‐of‐function deletion involving exons 1–4 of DRC1. A high‐speed video microscopy analysis showed motile cilia with reduced amplitude, and immunofluorescence (IF) showed the absence of DRC3 in the cilia, suggesting a DRC1 deletion affects DRC3 ...
Atsushi Kurokawa, Mitsuko Kondo, Mayoko Tsuji, Yuno Shiota, Azusa Miyoshi, Fumi Miyata, Keiko Kan‐o, Tomohiro Akaba, Ken Arimura, Osamitsu Yagi, Kaname Nakatani, Makoto Ikejiri, Kazuhiko Takeuchi, Etsuko Tagaya   +13 more
wiley   +1 more source

Stage‐Resolved Phosphoproteomic Landscape of Mouse Spermiogenesis Reveals Key Kinase Signaling in Sperm Morphogenesis

Advanced Science, Volume 12, Issue 44, November 27, 2025.
The quantitative proteomic and phosphoproteomic profiling reveals dynamic phosphorylation regulation of sperm morphogenesis. Kinase‐substrate phosphorylation network and phosphorylation module analysis, followed by in vivo knockdown and knockout analysis, identify TTBK2 and CSNK1G1 as key regulators of morphogenesis, including head, flagellar, and ...
Tianyu Zhu, Yan Zhu, Xinyi Jiang, Xiangzheng Zhang, Bing Wang, Yu Chen, Yichen Zhao, Yulian Wang, Qi Zhou, Zhongyan Han, Yaling Qi, Mengjiao Luo, Haixia Tu, Bingjie Hao, Mengmeng Gao, Jie Ren, Xin Zhou, Xingyu Zhang, Xu Chen, Haojie Li, Qian Huang, Chenghao Situ, Yueshuai Guo, Hui Zhu, Yan Li, Xuejiang Guo   +25 more
wiley   +1 more source

Incidental Diagnosis of Situs Inversus Totalis in a 45‐Year‐Old Male Who Presented With Acute Asthma Exacerbation: A Case Report and Brief Literature Review

Clinical Case Reports, Volume 13, Issue 11, November 2025.
ABSTRACT Incidental situs inversus totalis (SIT) requires thorough anatomical mapping to exclude associated syndromes (e.g., Kartagener) and congenital anomalies. Early identification, patient education on mirrored anatomy, and multidisciplinary coordination are essential to prevent iatrogenic errors during future interventions, even in asymptomatic ...
Ragasa Getachew Bayisa, Lensa Million Baharu, Mohammed Mecha Abafogi, Yosef Bekele Bonsa, Mohammed Kedir Shukri, Tamirat Godebo Woyimo   +5 more
wiley   +1 more source