Results 11 to 20 of about 736,342 (305)
Vesicular Trafficking, a Mechanism Controlled by Cascade Activation of Rab Proteins: Focus on Rab27
Biology, 2023 Vesicular trafficking is essential for the cell to internalize useful proteins and soluble substances, for cell signaling or for the degradation of pathogenic elements such as bacteria or viruses.
Camille Menaceur +4 more
doaj +1 more source
The blood–brain barrier: Structure, regulation and drug delivery
Signal Transduction and Targeted Therapy, 2023 Blood–brain barrier (BBB) is a natural protective membrane that prevents central nervous system (CNS) from toxins and pathogens in blood. However, the presence of BBB complicates the pharmacotherapy for CNS disorders as the most chemical drugs and ...
Di Wu +5 more
semanticscholar +1 more source
Cells, 2023 Within the neurovascular unit, brain pericytes (BPs) are of major importance for the induction and maintenance of the properties of the blood-brain barrier (BBB) carried by the brain microvessel endothelial cells (ECs).
Camille Menaceur +9 more
doaj +1 more source
Appearance of claudin-5+ leukocyte subtypes in the blood and CNS during progression of EAE
Journal of Neuroinflammation, 2021 Background Tight junctions (TJs) are membrane specializations characteristic of barrier-forming membranes, which function to seal the aqueous pathway between endothelial cells or epithelial cells and, thereby, obstruct intercellular solute and cellular ...
Dylan Krajewski +4 more
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Stem Cell Research & Therapy, 2021 Background Cell-based therapeutic strategies have been proposed as an alternative for brain repair after stroke, but their clinical application has been hampered by potential adverse effects in the long term.
Rodrigo Azevedo Loiola +14 more
doaj +1 more source
Between two storms, vasoactive peptides or bradykinin underlie severity of COVID‐19?
Physiological Reports, 2021 Coronavirus disease 2019 (COVID‐19), caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), continues to be a world‐wide pandemic with overwhelming socioeconomic impact.
Vardan T. Karamyan
doaj +1 more source
A blood–brain barrier overview on structure, function, impairment, and biomarkers of integrity
Fluids and Barriers of the CNS, 2020 The blood–brain barrier is playing a critical role in controlling the influx and efflux of biological substances essential for the brain’s metabolic activity as well as neuronal function.
Hossam Kadry, Behnam Noorani, L. Cucullo
semanticscholar +1 more source
Copper transport to the brain by the blood-brain barrier and blood-CSF barrier [PDF]
Brain Research, 2009 The mechanism of copper (Cu) transport into the brain is unclear. This study evaluated the main species and route of Cu transport into the brain using in situ brain perfusion technique, and assessed the levels of mRNA encoding Cu transporters using real time RT-PCR.
Byung-Sun, Choi, Wei, Zheng
openaire +2 more sources
Human ES-derived MSCs correct TNF-α-mediated alterations in a blood–brain barrier model
Fluids and Barriers of the CNS, 2019 Background Immune cell trafficking into the CNS is considered to contribute to pathogenesis in MS and its animal model, EAE. Disruption of the blood–brain barrier (BBB) is a hallmark of these pathologies and a potential target of therapeutics.
Shujun Ge +5 more
doaj +1 more source
Neurobiology of Disease, 2017 Experimental autoimmune encephalomyelitis (EAE) induced by active immunization of C57BL/6 mice with peptide from myelin oligodendrocyte protein (MOG35–55), is a neuroinflammatory, demyelinating disease widely recognized as an animal model of multiple ...
Bandana Shrestha +5 more
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