Results 31 to 40 of about 736,342 (305)

Transferrin Receptor Mediated Brain Uptake During Ischemia and Reperfusion

Journal of Pharmacy & Pharmaceutical Sciences, 2013
Purpose. Drug delivery by transferrin receptor-mediated transport at the blood-brain barrier has shown beneficial effects in animal models of stroke, but it is unclear whether receptor mediated uptake remains functional in the ischemic tissue.
Jiukuan Hao, Ulrich Bickel
doaj   +1 more source

Crossing the Blood-Brain Barrier: Advances in Nanoparticle Technology for Drug Delivery in Neuro-Oncology

International Journal of Molecular Sciences, 2022
The blood-brain barrier (BBB) constitutes a microvascular network responsible for excluding most drugs from the brain. Treatment of brain tumors is limited by the impermeability of the BBB and, consequently, survival outcomes for malignant brain tumors ...
Andrew M Hersh, Safwan O. Alomari, B. Tyler   +2 more
semanticscholar   +1 more source

P-selectin-targeted nanocarriers induce active crossing of the blood–brain barrier via caveolin-1-dependent transcytosis

Nature Materials, 2023
Targeting of tumour vasculature endothelial P-selectin promotes caveolin-1-mediated transcytosis for enhanced blood–brain barrier crossing of therapeutic nanoparticles against medulloblastoma. Medulloblastoma is the most common malignant paediatric brain
Daniel E Tylawsky, Hiroto Kiguchi, Jake Vaynshteyn, Jeffrey Gerwin, Janki Shah, Taseen Islam, Jacob A Boyer, D. Boue, M. Snuderl, M. Greenblatt, Yosi Shamay, G. P. Raju, Daniel A. Heller   +12 more
semanticscholar   +1 more source

Harmful Effects of Smoking Cannabis: A Cerebrovascular and Neurological Perspective

Frontiers in Pharmacology, 2019
Apart from being used as a medicine, cannabis or marijuana is the most widely abused recreational drug all over the world. The legalization and decriminalization of cannabis in Canada and various states of USA may be the underlying reason of the ...
Sabrina Rahman Archie, Luca Cucullo, Luca Cucullo   +2 more
doaj   +1 more source

Blood-Brain Barrier Dysfunction Amplifies the Development of Neuroinflammation: Understanding of Cellular Events in Brain Microvascular Endothelial Cells for Prevention and Treatment of BBB Dysfunction

Frontiers in Cellular Neuroscience, 2021
Neuroinflammation is involved in the onset or progression of various neurodegenerative diseases. Initiation of neuroinflammation is triggered by endogenous substances (damage-associated molecular patterns) and/or exogenous pathogens.
F. Takata, Shinsuke Nakagawa, Junichi Matsumoto, S. Dohgu   +3 more
semanticscholar   +1 more source

Accumulation of GD1α Ganglioside in MDA-MB-231 Breast Cancer Cells Expressing ST6GalNAc V

Molecules, 2015
α-Series gangliosides define a particular sub-class of glycosphingolipids containing sialic acid α2,6-linked to GalNAc residue that was isolated as a minor compound from the brain.
Sandy Vandermeersch, Jorick Vanbeselaere, Clément P. Delannoy, Aurore Drolez, Caroline Mysiorek, Yann Guérardel, Philippe Delannoy, Sylvain Julien   +7 more
doaj   +1 more source

Cannabinoids, Blood–Brain Barrier, and Brain Disposition

Pharmaceutics, 2020
Potential therapeutic actions of the cannabinoids delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) are based on their activity as analgesics, anti-emetics, anti-inflammatory agents, anti-seizure compounds.
Fabrizio Calapai, Luigi Cardia, Emanuela Elisa Sorbara, Michele Navarra, Sebastiano Gangemi, Gioacchino Calapai, Carmen Mannucci   +6 more
doaj   +1 more source

Endothelial activation and blood-brain barrier disruption in neurotoxicity after adoptive immunotherapy with CD19 CAR-T cells

Cancer Discovery, 2017
Lymphodepletion chemotherapy followed by infusion of CD19-targeted chimeric antigen receptor (CAR)-modified T (CAR-T) cells can be complicated by neurologic adverse events (AEs) in patients with refractory B cell malignancies.
J. Gust, K. Hay, K. Hay, L. Hanafi, Daniel H. Li, David Myerson, David Myerson, L. Gonzalez-Cuyar, Cecilia Yeung, Cecilia Yeung, W. Liles, M. Wurfel, José A. López, Junmei Chen, D. Chung, Susanna Harju-Baker, Tahsin Özpolat, Kathleen R. Fink, Stanley R. Riddell, Stanley R. Riddell, David G. Maloney, David G. Maloney, C. Turtle, C. Turtle   +23 more
semanticscholar   +1 more source

Factors influencing the blood-brain barrier permeability.

Brain Research, 2022
The blood-brain barrier (BBB) is a dynamic structure that protects the brain from harmful blood-borne, endogenous and exogenous substances and maintains the homeostatic microenvironment.
Yibin Zhao, Lin Gan, Li Ren, Yubo Lin, Congcong Ma, Xianming Lin   +5 more
semanticscholar   +1 more source

Blood-Brain Barrier Breakdown in the Aging Human Hippocampus

Neuron, 2015
Summary The blood-brain barrier (BBB) limits entry of blood-derived products, pathogens and cells into the brain that is essential for normal neuronal functioning and information processing. Post-mortem tissue analysis indicates BBB damage in Alzheimer’s
Axel Montagne, S. Barnes, Melanie D. Sweeney, Matthew R. Halliday, A. Sagare, Zhen Zhao, A. Toga, R. Jacobs, Collin Y. Liu, L. Amezcua, M. Harrington, H. Chui, M. Law, B. Zlokovic   +13 more
semanticscholar   +1 more source