Results 21 to 30 of about 736,342 (305)

Blood–brain barrier breakdown in Alzheimer’s disease and other neurodegenerative disorders

Nature Reviews Neurology, 2018
The blood–brain barrier (BBB) is a continuous endothelial membrane within brain microvessels that has sealed cell-to-cell contacts and is sheathed by mural vascular cells and perivascular astrocyte end-feet.
Melanie D. Sweeney, A. Sagare, B. Zlokovic   +2 more
semanticscholar   +1 more source

The blood–brain barrier in systemic infection and inflammation

Cellular & Molecular Immunology, 2021
The vascular blood–brain barrier is a highly regulated interface between the blood and brain. Its primary function is to protect central neurons while signaling the presence of systemic inflammation and infection to the brain to enable a protective ...
I. Galea
semanticscholar   +1 more source

The gut microbiota influences blood-brain barrier permeability in mice

Science Translational Medicine, 2014
The intestinal microbiota helps to maintain the integrity of the blood-brain barrier in fetal and adult mice. The Gut Microbiota and the Blood-Brain Barrier The blood-brain barrier is an important gateway that controls the passage of molecules and ...
V. Braniste, Maha Al-Asmakh, C. Kowal, F. Anuar, Afrouz Abbaspour, Miklós Tóth, Agata Korecka, N. Bakočević, L. Ng, Parag Kundu, B. Gulyás, C. Halldin, K. Hultenby, Harriet E. Nilsson, H. Hebert, B. Volpe, B. Diamond, S. Pettersson   +17 more
semanticscholar   +1 more source

What is the blood–brain barrier (not)? [PDF]

Trends in Immunology, 2007
In 1900, summarizing his experiments with toxins and Ehrlich's earlier observations with intravital dyes, the Berlin physician Lewandowski concluded that "brain capillaries must hold back certain molecules". Illustrating this phenomenon with persuasive beauty, the subsequently evolving metaphor of a 'Bluthirnschranke' (blood-brain barrier, BBB) gained ...
Ingo, Bechmann, Ian, Galea, V Hugh, Perry   +2 more
openaire   +2 more sources

Research progress on perioperative blood-brain barrier damage and its potential mechanism

Frontiers in Cell and Developmental Biology, 2023
The blood-brain barrier (BBB) is an important barrier separating the central nervous system from the periphery. The composition includes endothelial cells, pericytes, astrocytes, synapses and tight junction proteins.
Yong Qiu, Yong Qiu, Chunheng Mo, Shiyu Xu, Lu Chen, Lu Chen, Wanlin Ye, Wanlin Ye, Yi Kang, Yi Kang, Guo Chen, Guo Chen, Tao Zhu, Tao Zhu   +13 more
doaj   +1 more source

The blood-brain barrier in aging and neurodegeneration

Molecular Psychiatry, 2022
The blood-brain barrier (BBB) is vital for maintaining brain homeostasis by enabling an exquisite control of exchange of compounds between the blood and the brain parenchyma.
Emily G. Knox, M. R. Aburto, G. Clarke, J. Cryan, C. O’Driscoll   +4 more
semanticscholar   +1 more source

Blood-Brain Barriers in Obesity [PDF]

The AAPS Journal, 2017
After decades of rapid increase, the rate of obesity in adults in the USA is beginning to slow and the rate of childhood obesity is stabilizing. Despite these improvements, the obesity epidemic continues to be a major health and financial burden.
Elizabeth M, Rhea, Therese S, Salameh, Aric F, Logsdon, Angela J, Hanson, Michelle A, Erickson, William A, Banks   +5 more
openaire   +2 more sources

Blood-Brain Barrier: From Physiology to Disease and Back.

Physiological Reviews, 2019
The blood-brain barrier (BBB) prevents neurotoxic plasma components, blood cells, and pathogens from entering the brain. At the same time, the BBB regulates transport of molecules into and out of the central nervous system (CNS), which maintains tightly ...
Melanie D. Sweeney, Zhen Zhao, Axel Montagne, Amy R. Nelson, B. Zlokovic   +4 more
semanticscholar   +1 more source

Blood—Brain Barrier Genomics [PDF]

Journal of Cerebral Blood Flow & Metabolism, 2001
The blood–brain barrier (BBB) is formed by the brain microvascular endothelium, and the unique transport properties of the BBB are derived from tissue-specific gene expression within this cell. The current studies developed a gene microarray approach specific for the BBB by purifying the initial mRNA from isolated rat brain capillaries to generate ...
J Y, Li, R J, Boado, W M, Pardridge
openaire   +2 more sources

Extracellular vesicles: mediators and biomarkers of pathology along CNS barriers

Fluids and Barriers of the CNS, 2018
Extracellular vesicles (EVs) are heterogeneous, nano-sized vesicles that are shed into the blood and other body fluids, which disperse a variety of bioactive molecules (e.g., protein, mRNA, miRNA, DNA and lipids) to cellular targets over long and short ...
Servio H. Ramirez, Allison M. Andrews, Debayon Paul, Joel S. Pachter   +3 more
doaj   +1 more source