Results 111 to 120 of about 45,848 (279)

Caveolin‐1 enriched apoptotic bodies derived from oral hard palate orchestrate bone remodeling to treat heterotopic ossification

BMEMat, EarlyView.
Downregulated CAV1 in HO is restored via apoptotic bodies from PMSCs, which reprogram bone remodeling by delivering CAV1 to target cells, highlighting the therapeutic role of EV subtypes in heterotopic ossification. Abstract Heterotopic ossification (HO) is a pathological process characterized by ectopic bone formation in non‐osseous tissues, with an ...
Yuchen Wang, Like Tang, Zhou Yu, Wenjin Cai, Qifeng Jiang, Zhikang Wang, Yitong Chen, Kaichen Lai, Ying Wang, Tim Forouzanfar, Chiyuan Ma, Gang Wu, Tingben Huang, Guoli Yang   +13 more
wiley   +1 more source

miR-149-3p Regulates the Switch between Adipogenic and Osteogenic Differentiation of BMSCs by Targeting FTO

Molecular Therapy: Nucleic Acids, 2019
Bone marrow-derived mesenchymal stem cells (BMSCs) have been suggested to possess the capacity to differentiate into different cell lineages. Maintaining a balanced stem cell differentiation program is crucial to the bone microenvironment and bone ...
Yuan Li, Fan Yang, Manqi Gao, Rui Gong, Mengyu Jin, Tianyi Liu, Yi Sun, Yutuo Fu, Qi Huang, Wenwen Zhang, Shenzhen Liu, Meixi Yu, Gege Yan, C. Feng, Mingyu He, Lai Zhang, Fengzhi Ding, Wenya Ma, Z. Bi, Chaoqian Xu, Ye Yuan, Benzhi Cai, Lei Yang   +22 more
semanticscholar   +1 more source

Multifunctional polycaprolactone‐based composite fibers with icariin and glutathione for effective repair of critical‐sized bone defects

BMEMat, EarlyView.
A multifunctional PCL‐based scaffold co‐delivering Icariin and Glutathione synergistically enhances osteogenesis, angiogenesis, and oxidative stress resistance, achieving near‐complete repair of critical‐sized bone defects in vivo. This cell‐free platform represents a promising strategy for accelerated bone regeneration.
Abdurohman Mengesha Yessuf, Yaqi Zhang, Bharat Prasad Sharma, Yake Wang, Tibebu Shiferaw Kassa, Abdul Qadir, Ye Jinqiu, Mohamedazeem M. Mohideen, Ahmed M. Salama, Weiguo Wang, Qidong Zhang, Yong Liu   +11 more
wiley   +1 more source

Neuroprotective effect of normal and modified mesenchymal stem cell‐derived exosomes by mitigating Alzheimer's‐related oxidative and inflammatory damage via Nrf2/HO‐1 in SH‐SY5Y cells

Ibrain, EarlyView.
Exosome therapy shows promise in Alzheimer's disease. This study compared normal and modified exosomes from AD brain extract‐treated MSCs in STZ‐induced SH‐SY5Y cells. Exosomes improved neuronal viability, reduced oxidative stress and inflammation, and activated Nrf2/HO‐1 signaling.
Rishika Dhapola, Prajjwal Sharma, Sneha Kumari, Balachandar Vellingiri, Dibbanti HariKrishnaReddy   +4 more
wiley   +1 more source

Extracellular Vesicles Derived from H2O2-Stimulated Adipose-Derived Stem Cells Alleviate Senescence in Diabetic Bone Marrow Mesenchymal Stem Cells and Restore Their Osteogenic Capacity

Drug Design, Development and Therapy
Yu Li,1 Guangren Yue,1 Shuying Yu,1 Zheng Liu,1 Yilin Cao,1– 3 Ximei Wang1 1Department of Plastic and Reconstructive Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, People’s Republic of China; 2Shanghai Key Laboratory of Tissue
Li Y, Yue G, Yu S, Liu Z, Cao Y, Wang X
doaj  

Hemp (Cannabis sativa L.) Seed Protein and Its Hydrolysate Promote Bone Formation via the SMAD‐Dependent BMP Pathway

iNew Medicine, EarlyView.
ABSTRACT Objective With the global increase in aging populations, the prevalence of osteoporosis is rising. Current preventive and therapeutic strategies remain limited. The present study aimed to investigate the effects of hemp seed protein (HSP) and its hydrolysis‐derived bioactive peptides (HPH) on osteogenic differentiation and to elucidate their ...
Yan Wang, Jiameng Jia, Yang Yu, Kaiyuan Zheng, Meng Deng, Wei Chen, Guoming Liu, Ping Yi, Dongning Ling, Jing Zhang, Linfeng Liu, Bing Yang, Qing Wu, Ping Wei, Chong Yin   +14 more
wiley   +1 more source

LncRNA SNHG14 Delivered by Bone Marrow Mesenchymal Stem Cells‐Secreted Exosomes Regulates Osteogenesis and Adipogenesis in Osteoporosis by Mediating the miR‐27a‐3p/LMNB1 Axis

Kaohsiung Journal of Medical Sciences
The purpose of this study was to investigate the role of LncRNA SNHG14 delivered by bone marrow mesenchymal stem cells‐secreted exosomes (BMSC‐Exos) in osteoporosis (OP). BMSCs and BMSCs‐Exos were isolated and identified.
Jin‐Shan Tang, Huai‐Xi Yu, Ru‐Xin Ruan, Rui Chen, Zi‐Qiang Zhu   +4 more
doaj   +1 more source

Electroacupuncture combined with bone marrow mesenchymal stem cell transplantation promotes repair of thin endometrium by regulating SDF-1/CXCR4 signaling

针刺研究, 2023
ObjectiveIt is to explore， based on stromal cell derived factor 1 （SDF-1）/CXC chemokine receptor 4 （CXCR4） signal axis， whether the electroacupuncture （EA） combined with bone marrow mesenchymal stem cells （BMSCs） transplantation can promote thin ...
HAO Sai-nan, XIA Liang-jun, XI Jin, LIU Jing-yu, ZHU Qian, CHENG Jie, SHEN Jie, XIA You-bing   +7 more
doaj  

Effect of bone marrow mesenchymal stem cells modified with Toll-like receptor 4 on cardiac function in rats after acute myocardial infarction

Di-san junyi daxue xuebao, 2019
Objective To investigate the effect of bone marrow mesenchymal stem cells (BMSCs) modified with Toll-like receptor 4 (TLR4) on cardiac function in rats after acute myocardial infarction.
CHEN Wenming, IAN Minghui, QIU Zhimei, SHI Bei   +3 more
doaj   +1 more source

The regulation of stem cell fate and its application in neural regeneration

Interdisciplinary Medicine, EarlyView.
Regulating stem cell fate is crucial for neural regeneration. This review summarizes key physical, biological, and chemical strategies and their applications in repairing nerve injuries, providing new insights for regenerative medicine. Abstract Regulating the fate of stem cells (SCs) is a key technical problem in the field of regenerative medicine and
Yuexin He, Xingyu Chen, Minghong He, Zhe Li   +3 more
wiley   +1 more source