Results 101 to 110 of about 38,639 (266)

The Role of Extracellular Vesicles MicroRNAs in Sarcopenia: From Aging to Multi‐Morbidity

AGING MEDICINE, EarlyView.
Exosomes transporting miRNAs play a crucial bidirectional regulatory role in the process of sarcopenia, both in natural aging and under various pathological conditions. ABSTRACT Sarcopenia, defined as progressive loss of skeletal muscle mass and function, occurs during aging and has also been recognized for its detrimental effects in various disease ...
Bingyu Huang, Zhao Peng, Lin Kang
wiley   +1 more source

Bone marrow stromal cells attenuate sepsis via prostaglandin E2— dependent reprogramming of host macrophages to increase their interleukin-10 production [PDF]

, 2009
Sepsis causes over 200,000 deaths yearly in the US; better treatments are urgently needed. Administering bone marrow stromal cells (BMSCs—also known as mesenchymal stem cells) to mice before or shortly after inducing sepsis by cecal ligation and ...
A Bal-Price, A Corcione, AK Nussler, Alissa Parmelee, AN Hata, Asada Leelahavanichkul, Balázs Mayer, Beverly H Koller, C Lange, CS Bonder, D Noel, E Mansilla, F Togel, F Togel, G Chamberlain, H Jaeschke, H Yasuda, I Rasmusson, Ivett Jelinek, J Wang, Jared M Brown, JM van Laar, K Le Blanc, K Le Blanc, Kantima Leelahavanichkul, Kent Doi, Krisztián Németh, KW Moore, L Ulloa, LA Hernandez, M Kasai, M Perretti, M Pevsner-Fischer, MA Cassatella, MN Ajuebor, N van Rooijen, O Ringden, P Bianco, P Semedo, PA Sotiropoulou, Pamela G Robey, Peter S T Yuen, PR Crisostomo, PY Bochud, RA Matthijsen, RG Ramsay, Robert A Star, S Aggarwal, S Habu, S Kubo, S Nakao, S Shinomiya, T Calandra, T Miyaji, WJ Hubbard, Xuzhen Hu, Y Imai, Y Shinkai, YJ Jung, YK Park, Éva Mezey   +60 more
core   +2 more sources

Artificial Intelligence for Bone: Theory, Methods, and Applications

Advanced Intelligent Discovery, EarlyView.
Advances in artificial intelligence (AI) offer the potential to improve bone research. The current review explores the contributions of AI to pathological study, biomarker discovery, drug design, and clinical diagnosis and prognosis of bone diseases. We envision that AI‐driven methodologies will enable identifying novel targets for drugs discovery. The
Dongfeng Yuan, Haicang Zhang, Liping Tong, Di Chen   +3 more
wiley   +1 more source

Isomangiferin promotes the migration and osteogenic differentiation of rat bone marrow mesenchymal stem cells

Open Life Sciences
Delayed or failed bone healing is a significant clinical challenge worldwide. Bone marrow mesenchymal stem cells (BMSCs) offer a promising approach for improving fracture healing.
Gao Bingjun, Cheng Xin, Wu Yarong, Jiang Boyi   +3 more
doaj   +1 more source

Small vesicles, big potential: A review of innovative exosome delivery and molecular mechanisms in preclinical myocardial infarction models

Animal Models and Experimental Medicine, EarlyView.
This narrative review discusses animal models of exosome‐based myocardial infarction treatments. Emerging techniques aim to improve exosome stability, targeting, and bioavailability for MI treatment as drug delivery vehicles and regenerative mediators that promote myocardial regeneration. Abstract Exosomes have emerged as promising therapeutic carriers,
Chayanisa Phutiyothin, Kovit Pattanapanyasat, Sarawut Kumphune   +2 more
wiley   +1 more source

Therapeutic Effects of VEGF Gene-Transfected BMSCs Transplantation on Thin Endometrium in the Rat Model

Stem Cells International, 2018
Objective. Bone mesenchymal stem cells (BMSCs) transplantation has a therapeutic effect on the thin endometrium in animal researches and clinical trials.
Zhao Jing, Yan Yi, Huang Xi, Lun-Quan Sun, Li Yanping   +4 more
doaj   +1 more source

Apoptosis of mesenchymal stem cells is regulated by Rspo1 via the Wnt/β-catenin signaling pathway

Chronic Diseases and Translational Medicine, 2019
Objective: The aim of this study was to investigate the effect and possible mechanism of action of roof plate-specific spondin1 (Rspo1) in the apoptosis of rat bone marrow mesenchymal stem cells (BMSCs). Methods: Osteogenic and adipogenic differentiation
Xiao-Xia Cheng, Qiao-Yan Yang, Yong-Li Qi, Zhi-Zhen Liu, Dan Liu, Sheng He, Li-Hong Yang, Jun Xie   +7 more
doaj   +1 more source

Nanoclay‐Engineered Scaffolds for the Controlled Delivery of Biomolecules in Regenerative Medicine

Asia-Pacific Journal of Chemical Engineering, EarlyView.
ABSTRACT Regenerative medicine combines biomaterials, cells, scaffolds, and bioactive agents via modern technologies to aid in the reconstruction and repair of damaged tissues. Among these, nanoclay scaffolds have demonstrated unique advantages in facilitating the delivery of therapeutic agents.
Mehri Shadi, Saeed Vafaei‐Nezhad, Ahmad Gholamalizadeh Ahangar   +2 more
wiley   +1 more source

Donor age and cell passage affects differentiation potential of murine bone marrow-derived stem cells [PDF]

, 2008
Background Bone marrow-derived mesenchymal stem cells (BMSCs) are a widely researched adult stem cell population capable of differentiation into various lineages.
James D Kretlow, Yu-Qing Jin, Wei Liu, Wen Zhang, Tan-Hui Hong, Guangdong Zhou, L Scott Baggett, Antonios G Mikos, Yilin Cao   +8 more
core   +1 more source

Neuronal differentiation and tissue engineering strategies for central neurous system injury repair

BMEMat, EarlyView.
This review outlines tissue engineering advances for central nervous system (CNS) injury treatment, focusing on three core components: seed cells, inductive factors, and scaffold materials, with evaluation of their respective strengths and limitations. Tissue engineering for CNS injury repair.
Zhuqing Xia, Jinghui Zhang, Na Ren, Shuping Wang, Congcong Zhang, Nik Ahmad Nizam Nik Malek, Wan Hairul Anuar Kamaruddin, Chao Liu, Chunhui Sun, Jingang Wang   +9 more
wiley   +1 more source