Results 81 to 90 of about 45,848 (279)

The osteoinductive and osseointegration properties of decellularized extracellular matrix bone derived from different sites

Bone & Joint Research
Aims: This study aimed to examine the differences in bone induction and osseointegration performance of acellular extracellular matrix bone at different sites.
Weihua Huang, Lijing Hao, Xiayu Cai, Chujie Xiao, Huinan Yin, Weikang Xu   +5 more
doaj   +1 more source

Ultrasound-targeted microbubble destruction optimized HGF-overexpressing bone marrow stem cells to repair fibrotic liver in rats

Stem Cell Research & Therapy, 2020
Background/aims Bone marrow mesenchymal stem cells (BMSCs) have shown their therapeutic potential in cytotherapy for liver fibrosis. However, the insufficient homing of BMSCs and undefined proliferation of BMSCs represent a significant challenge and ...
Ting Sun, Hualin Li, Yun Bai, Min Bai, Feng Gao, Jie Yu, Rong Wu, Lianfang Du, Fan Li   +8 more
doaj   +1 more source

Nanog/NFATc1/Osterix signaling pathway-mediated promotion of bone formation at the tendon–bone interface after ACL reconstruction with De-BMSCs transplantation

Stem Cell Research & Therapy, 2021
Background Bone formation plays an important role in early tendon–bone healing after anterior cruciate ligament reconstruction (ACLR). Dedifferentiated osteogenic bone marrow mesenchymal stem cells (De-BMSCs) have enhanced osteogenic potential.
Kai Tie, Jinghang Cai, Jun Qin, Hao Xiao, Yangfan Shangguan, Hui Wang, Liaobin Chen   +6 more
doaj   +1 more source

YAP1‐Driven Pathogenic Fibro‐Adipogenic Progenitors Secrete IL‐6 and FGF21 to Mediate Muscle‐Bone Crosstalk and Promote Bone Loss

Advanced Science, EarlyView.
Fibro‐adipogenic progenitors (FAPs) in atrophic muscle undergo YAP1‐driven pathogenic activation, secreting IL‐6 and FGF21 as bone‐catabolic myokines that mediate muscle‐bone crosstalk and promote bone loss. Genetic or pharmacological targeting of this YAP1‐FAP‐myokine axis rescues skeletal deterioration, identifying FAP‐derived myokines as therapeutic
Xiaoyu Cai, Tao Xu, Rui Ma, Weikun Meng, Shutao Gao, Yakefu Abulizi, Alafate Kahaer, Chuanhui Xun, Maierdan Maimaiti, Rui Cao, Weidong Liang, Polati Maimaiti, Qiang Deng, Jun Sheng, Ting Wang, Mingchong Liu, Weibin Sheng   +16 more
wiley   +1 more source

Suppressing PLCγ1 enhances osteogenic and chondrogenic potential of BMSCs

Biochemical and Biophysical Research Communications, 2020
Phosphatidylcholine-specific phospholipase Cγ1 (PLCγ1) is involved in regulating cell metabolism. However, little is known how PLCγ1 directs BMSC differentiation. Here, we investigated the role of PLCγ1 in rat BMSC differentiation into osteoblasts and chondrocytes.
Xiaolei, Chen, Yue, Wang, Ri, Chen, Ning, Qu, Bing, Zhang, Chun, Xia   +5 more
openaire   +2 more sources

Gαi1/3 Are Essential for BMP2‐Induced Osteogenesis by Bridging BMP Receptors to the Gab1 Signaling Complex

Advanced Science, EarlyView.
The Gαi1/3 protein is a crucial connecting protein closely related to the signal transduction process of bone formation‐related cytokines such as BMP2. Gαi1/3 mediates downstream signaling pathways such as Smads and MAPK by binding to adaptor proteins like Gab1, thereby promoting the osteogenic effect of BMSCs.
Huajian Shan, Chaowen Bai, Yifei Zhu, Chenyang Xu, Sonngtao Li, Qize Sun, Chang She, Jinyu Bai, Cong Cao, Yitian Yang, Xiaozhong Zhou   +10 more
wiley   +1 more source

Doxorubicin Caused Apoptosis of Mesenchymal Stem Cells via p38, JNK and p53 Pathway

Cellular Physiology and Biochemistry, 2013
Background/Aims: Doxorubicin is a widely used chemotherapeutic agent, but its clinical use is restricted because of a high risk of cardiotoxicity. Bone marrow-derived mesenchymal stem cells (BMSCs) may repair ischaemically damaged myocardium through ...
Fan Yang, Hongyang Chen, Yanju Liu, Kun Yin, Yang Wang, Xingda Li, Guohui Wang, Siyue Wang, Xueying Tan, Chaoqian Xu, Yanjie Lu, Benzhi Cai   +11 more
doaj   +1 more source

Renal Tubular Epithelial CRLF1 Interacts With ITGB1 to Accelerate Fibrosis During the Transition From AKI to CKD

Advanced Science, EarlyView.
During renal fibrosis, SMAD3 acts as a transcription factor for CRLF1, promoting its expression and secretion. CRLF1 then binds to ITGB1 via an autocrine mechanism, activating the PI3K‐AKT signaling pathway to mediate renal fibrosis. This accelerates the progression from AKI to CKD, highlighting the therapeutic potential of targeting CRLF1 for ...
Chunjie Wang, Yan Zhang, Fang Bai, Shankui Qian, Feng Feng, Fangyi Lu, Jiahui Fan, Kuipeng Yu, Xiangdong Yang   +8 more
wiley   +1 more source

The Role of Tantalum Nanoparticles in Bone Regeneration Involves the BMP2/Smad4/Runx2 Signaling Pathway [Retraction]

International Journal of Nanomedicine, 2020
Zhang G, Liu W, Wang R, et al. Int J Nanomedicine. 2020;15:2419–2435. The Editor-in-Chief and Publisher of International Journal of Nanomedicine wish to retract the published article. We were notified of potential image duplications found
Zhang G, Liu W, Wang R, Zhang Y, Chen L, Chen A, Luo H, Zhong H, Shao L   +8 more
doaj  

Ascorbic acid 2-glucoside preconditioning enhances the ability of bone marrow mesenchymal stem cells in promoting wound healing

Stem Cell Research & Therapy, 2022
Background Nowadays, wound is associated with a complicated repairing process and still represents a significant biomedical burden worldwide. Bone marrow mesenchymal stem cells (BMSCs) possess multidirectional differentiation potential and secretory ...
Yi Yi, Min Wu, Xiaomei Zhou, Mingchen Xiong, Yufang Tan, Honghao Yu, Zeming Liu, Yiping Wu, Qi Zhang   +8 more
doaj   +1 more source