Results 51 to 60 of about 126,969 (147)

Ouabain stimulates a Na+/K+-ATPase-mediated SFK-activated signalling pathway that regulates tight junction function in the mouse blastocyst. [PDF]

PLoS ONE, 2011
The Na(+)/K(+)-ATPase plays a pivotal role during preimplantation development; it establishes a trans-epithelial ionic gradient that facilitates the formation of the fluid-filled blastocyst cavity, crucial for implantation and successful pregnancy.
Holly Giannatselis, Michele Calder, Andrew J Watson   +2 more
doaj   +1 more source

Bufalin Inhibits Melanoma Progression and Endothelial Angiogenic Phenotypes via AKT Signaling

Cancer Reports, Volume 9, Issue 9, September 2026.
ABSTRACT Introduction Bufalin (BF) exhibits anti‐tumor activity in many tumor types. However, there are few reports on BF in melanoma, and its pharmacological effects have not yet been elucidated. The present study aimed to investigate the effects of BF on melanoma and angiogenesis and to explore its possible mechanism.
Xiao xuan Zhao, Ming xin Li, Jiang xue Qu   +2 more
wiley   +1 more source

Super-resolution microscopy reveals that Na+/K+-ATPase signaling protects against glucose-induced apoptosis by deactivating Bad

Cell Death and Disease, 2021
Activation of the apoptotic pathway is a major cause of progressive loss of function in chronic diseases such as neurodegenerative and diabetic kidney diseases.
Kristoffer Bernhem, Jacopo M. Fontana, Daniel Svensson, Liang Zhang, Linnéa M. Nilsson, Lena Scott, Hans Blom, Hjalmar Brismar, Anita Aperia   +8 more
doaj   +1 more source

Altered circulating marinobufagenin levels and recurrent intradialytic hypotensive episodes in chronic hemodialysis patients: a pilot, prospective study

Reviews in Cardiovascular Medicine, 2021
Intradialytic hypotension (IDH) is a sudden and often serious complication of chronic hemodialysis (HD). In this prospective study, we aimed at evaluating the clinical predictors of IDH in a homogeneous cohort of chronic HD patients, with a particular
Davide Bolignano, Marta Greco, Pierangela Presta, Giuseppina Crugliano, Jolanda Sabatino, Nazareno Carullo, Roberta Arena, Isabella Leo, Alessandro Comi, Michele Andreucci, Francesco Dragone, Antonio Strangio, Ciro Indolfi, Daniela Patrizia Foti, Salvatore De Rosa, Giuseppe Coppolino   +15 more
doaj   +1 more source

Neurocardiology: Brain–Heart Interactions in the Heart

MedComm, Volume 7, Issue 9, September 2026.
The heart and brain maintain systemic homeostasis through bidirectional communication involving neural, biochemical, and mechanical pathways. Dysregulation of these pathways contributes to a spectrum of conditions involving heart–brain interactions, including Takotsubo syndrome, the epileptic heart, stroke–heart syndrome, heart failure, cardiac ...
Wentao Wang, Hao Jia, Han Han, Jiangping Song   +3 more
wiley   +1 more source

Response Surface Method‐Optimized Microwave‐Assisted Extraction and LC–MS/MS Profiling of Bioactive Compounds Wild Edible Arisaema schimperianum Tuber

SEPARATION SCIENCE PLUS, Volume 9, Issue 9, September 2026.
Response surface optimization identified 60% microwave power and 40 s as a balanced condition for recovering bioactive compounds from Arisaema schimperianum tuber. LC–MS/MS profiling revealed diverse metabolites, while freeze‐drying best preserved thermolabile compounds, highlighting an effective strategy for maximizing extraction efficiency and ...
Gezahegn Abawa Zeleke, Shimelis Admassu Emire, Maryna De Wit   +2 more
wiley   +1 more source

DHCR24 Alleviates DNA Damage in Senescent Vascular Endothelial Cells via ENKUR/Ca2+ Signaling

Aging Cell, Volume 25, Issue 9, September 2026.
In senescent vascular endothelial cells, DHCR24 deficiency triggers ENKUR‐dependent Ca2+ overload, which in turn induces endoplasmic reticulum stress and mitochondrial dysfunction, ultimately exacerbating oxidative stress and DNA damage. ABSTRACT DNA damage is considered one of the major contributors to aging.
Han Li, Zhen Yang, Wukaiyang Liang, Jie Huang, Tianyi Ji, Hao Nie, Zixin Wan, Yuqi Qiu, Yi Huang, Le Zhang, Cuntai Zhang, Jinhua Yan   +11 more
wiley   +1 more source

Exploring Floristic Diversity and Medicinal Plant Uses in Venda, Limpopo, South Africa

Feddes Repertorium, Volume 137, Issue 2, June 2026.
ABSTRACT Plants have been an important source of medicine for thousands of years. To better understand the current diversity and usage of medicinal plants, floristic studies are essential. This report documents an expedition conducted in the Venda region of Limpopo, South Africa. The study was carried out in Shanzha and surrounding villages, as well as
Gurusamy Manikandan, Iliassou L. Mouafon, David R. Katerere   +2 more
wiley   +1 more source

Ouabain‐induced hypertension in rats: Mechanisms, variability and translational implications

Experimental Physiology, Volume 111, Issue 3, Page 653-673, 1 March 2026.
Abstract Ouabain‐induced hypertension is a multifactorial and condition‐dependent phenomenon involving coordinated actions across vascular, renal and central nervous system pathways. At the vascular level, ouabain inhibits Na⁺/K⁺‐ATPase, particularly the α2‐isoform, leading to elevated intracellular Ca2⁺, enhanced vasoconstriction and structural ...
Priscilla Rodrigues O. Feijó, Luis Eduardo M. Quintas   +1 more
wiley   +1 more source

Urinary Marinobufagenin in Patients with Non-Advanced Chronic Kidney Disease: A Cross-Sectional Study

Medicina, 2023
Background and Objectives: The global prevalence of chronic kidney disease (CKD) is on the rise, posing important challenges for healthcare systems. Thus, the search for new factors potentially involved in the pathogenesis, progression and complications ...
Davide Bolignano, Marta Greco, Mario D’Agostino, Paola Cianfrone, Loredana Tripodi, Roberta Misiti, Mariateresa Zicarelli, Ludovica Ganino, Daniela Patrizia Foti, Michele Andreucci, Giuseppe Coppolino   +10 more
doaj   +1 more source