Results 61 to 70 of about 126,969 (147)

Krisanaklan Reduces Intestinal Anion and Fluid Secretion Through Inhibition of Na+/K+‐ATPase and K+ Channel Activity

Annals of the New York Academy of Sciences, Volume 1556, Issue 1, February 2026.
Krisanaklan reduces CFTR‐dependent intestinal chloride and fluid secretion by inhibiting the Na+,K+‐ATPase and K+ channels in epithelial cells. Consequently, this natural, plant‐derived product may limit secretory diarrhea caused by a diverse array of microbial pathogens. However, by dissipating the transmembrane Na+ gradient, Krisanaklan also inhibits
Tessa A. Groeneweg, Erdene Baigal, Anny Leung, Gert‐Jan Kremers, Marcel J. C. Bijvelds   +4 more
wiley   +1 more source

Cardiotonic STEROIDS-MEDIATED Na+/K+-ATPase targeting could circumvent various chemoresistance pathways

, 2013
Many cancer patients fail to respond to chemotherapy because of the intrinsic resistance of their cancer to pro-apoptotic stimuli or the acquisition of the multidrug resistant phenotype during chronic treatment.
Mijatovic, Tatjana, Kiss, Robert
core   +1 more source

Ouabagenin is a naturally occurring LXR ligand without causing hepatic steatosis as a side effect

Scientific Reports, 2018
Ouabagenin (OBG) is an aglycone of the cardiotonic steroid ouabain and until now was considered a biologically inactive biosynthetic precursor. Herein, we revealed that OBG functions as a novel class of ligand for the liver X receptor (LXR).
Satoru Tamura, Maiko Okada, Shigeaki Kato, Yasuharu Shinoda, Norifumi Shioda, Kohji Fukunaga, Kumiko Ui-Tei, Minoru Ueda   +7 more
doaj   +1 more source

Integrative Omics Defines Metabolic Biomarkers and Genetic Regulatory Mechanisms of Mortality Risk

Advanced Science, Volume 13, Issue 3, 14 January 2026.
Understanding mortality mechanisms remains a fundamental challenge. Through multi‐omics analysis of a three‐generation chicken model, are identified 45,585 mQTLs and establish a 16‐metabolite predictor of mortality. An inflammation‐growth trade‐off and evolutionarily conserved pathways involving butyrate–microbiota interactions and L‐cysteine's dual ...
Peihao Liu, Bingxing An, Jumei Zheng, Qiao Wang, Zhirui Yang, Zhengda Li, Dawei Liu, Fan Ying, Jie Wen, Lingzhao Fang, Guiping Zhao   +10 more
wiley   +1 more source

CARDIOTONIC STEROIDS AS MODULATORS OF NEURONAL SURVIVAL SIGNALING PATHWAYS: A REVIEW OF CURRENT RESEARCH

Brain cell metabolism is characterized by numerous cellular and molecular mechanisms. Exposure of brain cells to damaging factors leads to mitochondrial dysfunction, the accumulation of ...
E. A. Teplyashina, L. B. Shadrina
core   +1 more source

Na,K-ATPase mediated and cardiotonic induced signaling in health and disease

Frontiers in Physiology
In the late 1950’s, Na,K-ATPase (NKA) was discovered as the active transport system that establishes and maintains the transmembrane Na+ and K+ gradients necessary for cell survival and function. Almost 70 years later, a novel unexpected function for NKA
Jordan Trant, Jenna Beth Lowery, Pedro Morales-Sosa, Gustavo Blanco   +3 more
doaj   +1 more source

Exploring the Cancer Therapeutic Potential of Traditional Medicinal Plants by Modulating the Apoptotic Pathway

BioMed Research International, Volume 2026, Issue 1, 2026.
Introduction Cancer is a versatile disease with a high rate of relapse and mortality. Despite the presence of various treatment modalities, there is a serious need for the development of its management. Phytochemicals, which are abundant in nature, can be turned into novel medications for these types of diseases by optimizing their functions and ...
Mithila Kulkarni, Mohammad Amjad Hussain, Reginald Samson Valdar, Shreya Hebbar, Suparna Laha, Poorani Gurumallesh Prabu   +5 more
wiley   +1 more source

Characterization of equine GST A3-3 as a steroid isomerase

, 2018
Glutathione transferases (GSTs) comprise a superfamily of enzymes prominently involved in detoxication by making toxic electrophiles more polar and therefore more easily excretable. However some GSTs have developed alternative functions.
Helena Lindström, Peer, Shawna M., Ing, Nancy H., Shawna M. Peer, Bengt Mannervik, Lindström, Helena,, Nancy H. Ing, Mannervik, Bengt,   +7 more
core   +1 more source

Medicinal Plants Used by Tanzanians for Human Paediatric Ailments: A PRISMA‐Guided Systematic Review of Ethnomedicinal Evidence

The Scientific World Journal, Volume 2026, Issue 1, 2026.
Paediatric ailments (PAs) pose an increasing health and economic challenge in many low‐ and middle‐income countries. In Tanzania, over 80% of the rural population relies on traditional medicine for primary healthcare. Although documentation of medicinal plants (MPs) used to treat and manage PAs remains fragmented, this systematic review consolidates ...
David Sylvester Kacholi, Neema Gideon Mogha, José Agustín Tapia Hernández   +2 more
wiley   +1 more source

ATP1A1 is a promising new target for melanoma treatment and can be inhibited by its physiological ligand bufalin to restore targeted therapy efficacy

Cancer Cell International
Despite advancements in treating metastatic melanoma, many patients exhibit resistance to targeted therapies. Our study focuses on ATP1A1, a sodium pump subunit associated with cancer development.
Laura Soumoy, Aline Genbauffe, Lena Mouchart, Alexandra Sperone, Anne Trelcat, Léa Mukeba-Harchies, Mathilde Wells, Bertrand Blankert, Ahmad Najem, Ghanem Ghanem, Sven Saussez, Fabrice Journe   +11 more
doaj   +1 more source