Journal of Pharmacological Sciences, 2011 The present study investigated the function of caspase-4 in endoplasmic reticulum (ER) stress–induced apoptosis in human neuronal cell line SH-SY5Y.
Akiko Yamamuro +6 more
doaj +5 more sources
Interleukin-17F suppressed colon cancer by enhancing caspase 4 mediated pyroptosis of endothelial cells [PDF]
Scientific ReportsThe combination of anti-angiogenic treatment and immunotherapy presents a promising strategy against colon cancer. Interleukin-17F (IL-17F) emerges as a critical immune cell cytokine expressed in colonic epithelial cells, demonstrating potential in ...
Ying Zhou +9 more
doaj +2 more sources
Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death [PDF]
Nature Communications, 2017 Apoptosis is a genetically regulated cell suicide programme mediated by activation of the effector caspases 3, 6 and 7. If apoptotic cells are not scavenged, they progress to a lytic and inflammatory phase called secondary necrosis.
Lindsey Mayes +2 more
exaly +3 more sources
Gasdermin-D pores induce an inactivating caspase-4 cleavage that limits IL-18 production in the intestinal epithelium [PDF]
Communications BiologyIntestinal epithelial-derived IL-18 is critical for homeostatic intestinal barrier function and is secreted through Gasdermin D (GSDMD) pores. Inflammasome activation is a prerequisite for both IL-18 maturation and GSDMD pore formation.
J. K. Bruce +12 more
doaj +2 more sources
Identification of a novel subpopulation of Caspase-4 positive non-small cell lung Cancer patients [PDF]
Journal of Experimental & Clinical Cancer Research, 2020 Background Therapy/prognosis of Non-Small Cell Lung Cancer (NSCLC) patients are strongly related to gene alteration/s or protein expression. However, more than 50% of NSCLC patients are negative to key drugable biomarkers.
Michela Terlizzi +11 more
doaj +2 more sources
The colonic pathogen Entamoeba histolytica activates caspase-4/1 that cleaves the pore-forming protein gasdermin D to regulate IL-1β secretion. [PDF]
PLoS Pathogens, 2022 A hallmark of Entamoeba histolytica (Eh) invasion in the gut is acute inflammation dominated by the secretion of pro-inflammatory cytokines TNF-α and IL-1β.
Shanshan Wang +2 more
doaj +2 more sources
Bacterial virulence factor inhibits caspase-4/11 activation in intestinal epithelial cells [PDF]
Mucosal Immunology, 2017 The human pathogen enteropathogenic Escherichia coli (EPEC), as well as the mouse pathogen Citrobacter rodentium, colonize the gut mucosa via attaching and effacing lesion formation and cause diarrheal diseases. EPEC and C.
Berger, C. N. +9 more
core +8 more sources
Human caspase-4 detects tetra-acylated LPS and cytosolic Francisella and functions differently from murine caspase-11 [PDF]
Nature Communications, 2018 Lipid A from some bacteria is sensed differently by humans and mice for the activation of the inflammasomes and inflammatory responses, but the mechanisms are not clear.
Brice Lagrange +10 more
doaj +6 more sources
Lipopolysaccharide Recognition in the Crossroads of TLR4 and Caspase-4/11 Mediated Inflammatory Pathways [PDF]
Frontiers in Immunology, 2020 The innate immune response to lipopolysaccharide is essential for host defense against Gram-negative bacteria. In response to bacterial infection, the TLR4/MD-2 complex that is expressed on the surface of macrophages, monocytes, dendritic, and epithelial
Alla Zamyatina, Holger Heine
doaj +2 more sources
Resurrection of an ancient inflammatory locus reveals switch to caspase-1 specificity on a caspase-4 scaffold. [PDF]
J Biol Chem, 2022 Pyroptosis is a mechanism of inflammatory cell death mediated by the activation of the prolytic protein gasdermin D by caspase-1, caspase-4, and caspase-5 in human, and caspase-1 and caspase-11 in mouse. In addition, caspase-1 amplifies inflammation by proteolytic activation of cytokine interleukin-1β (IL-1β). Modern mammals of the order Carnivora lack
Bibo-Verdugo B +7 more
europepmc +3 more sources