Results 21 to 30 of about 467,366 (285)
Noncanonical Roles of Caspase-4 and Caspase-5 in Heme-Driven IL-1β Release and Cell Death. [PDF]
J Immunol, 2021 Abstract Excessive release of heme from RBCs is a key pathophysiological feature of several disease states, including bacterial sepsis, malaria, and sickle cell disease. This hemolysis results in an increased level of free heme that has been implicated in the inflammatory activation of monocytes, macrophages, and the endothelium.
Bolívar BE +8 more
europepmc +4 more sources
Inflammation in Hypervolemic Hemodialysis Patients: The Roles of RelB and Caspase-4. [PDF]
Int J Mol Sci, 2023 Hypervolemia is associated with inflammation in hemodialysis (HD) patients. How hypervolemia triggers inflammation is not entirely known. We initiated a cross-sectional study enrolling 40 hemodialysis patients who were categorized into normovolemic (N; 23) and hypervolemic (H; 17) groups by bioimpedance measurement.
Ulrich C +4 more
europepmc +4 more sources
Cell Reports, 2021 Summary: Zoonotic pathogens, such as COVID-19, reside in animal hosts before jumping species to infect humans. The Carnivora, like mink, carry many zoonoses, yet how diversity in host immune genes across species affect pathogen carriage is poorly ...
Zsofi Digby +13 more
doaj +1 more source
Neutrophils Orchestrate the Periodontal Pocket
Frontiers in Immunology, 2021 The subgingival biofilm attached to tooth surfaces triggers and maintains periodontitis. Previously, late-onset periodontitis has been considered a consequence of dysbiosis and a resultant polymicrobial disruption of host homeostasis.
Ljubomir Vitkov +13 more
doaj +1 more source
Geranylgeranoic acid, a bioactive and endogenous fatty acid in mammals: a review
Journal of Lipid Research, 2023 Geranylgeranoic acid (GGA) was first reported in 1983 as one of the mevalonic acid metabolites, but its biological significance was not studied for a long time.
Yoshihiro Shidoji
doaj +1 more source
Frontiers in Genetics, 2021 The dysregulation of caspase 4 (CASP4) expression is related to the occurrence, development, and outcome of many malignant tumors; however, its role in clear cell renal cell carcinoma (ccRCC) remains unclear.
Lingfeng Meng +12 more
doaj +1 more source
Caspase-4: A Therapeutic Target for Peptic Ulcer Disease [PDF]
ImmunoHorizons, 2020 Abstract Peptic ulcers are caused by the interaction between bacterial and host factors. This study demonstrates enhanced expression of caspase-4 in peptic ulcer patient biopsies, indicating that pyroptosis and noncanonical inflammasome activity may be processes involved in peptic ulcer disease.
Zbigniew Zaslona +9 more
openaire +2 more sources
Frontiers in Immunology, 2023 IntroductionHuman adenovirus (HAdV) is a common respiratory virus, which can lead to severe pneumonia in children and immunocompromised persons, and canonical inflammasomes are reported to be involved in anti-HAdV defense.
Lexi Li +9 more
doaj +1 more source
Caspase-12 and Caspase-4 Are Not Required for Caspase-dependent Endoplasmic Reticulum Stress-induced Apoptosis [PDF]
Journal of Biological Chemistry, 2005 Alterations in cellular homeostasis that affect protein folding in the endoplasmic reticulum (ER) trigger a signaling pathway known as the unfolded protein response (UPR). The initially cytoprotective UPR will trigger an apoptotic cascade if the cellular insult is not corrected; however, the proteins required to initiate this cell death pathway are ...
Esther A, Obeng, Lawrence H, Boise
openaire +2 more sources
Caspase-4 Is Required for Activation of Inflammasomes [PDF]
The Journal of Immunology, 2012 Abstract IL-1β and IL-18 are crucial regulators of inflammation and immunity. Both cytokines are initially expressed as inactive precursors, which require processing by the protease caspase-1 for biological activity. Caspase-1 itself is activated in different innate immune complexes called inflammasomes.
Sollberger, Gabriel +4 more
openaire +3 more sources