Results 31 to 40 of about 467,366 (285)

Pyroptosis: A Common Feature of Immune Cells of Haemodialysis Patients

Toxins, 2021
NLRP-3 inflammasome activation can result in interleukin-1β (IL-1β) release and inflammatory cell death (pyroptosis). Caspase-1 is able to trigger both processes.
Christof Ulrich, Leonie Kneser, Roman Fiedler, Julia Beckert, Susann Wildgrube, Eric Seibert, Sylvia Fick, Christoph Schäfer, Silke Markau, Bogusz Trojanowicz, Matthias Girndt   +10 more
doaj   +1 more source

Increased expression of caspase 1 during active phase of connective tissue disease [PDF]

PeerJ, 2019
Key factors of pyroptosis play an important role in the inflammatory response to connective tissue disease (CTD). However, information on active and stable stages of CTD is scarce.
Rentian Cai, Qiongqiong Wang, Gongmin Zhu, Liying Zhu, Zhen Tao   +4 more
doaj   +2 more sources

Noncanonical Inflammasome Activation of Caspase-4/Caspase-11 Mediates Epithelial Defenses against Enteric Bacterial Pathogens [PDF]

Cell Host & Microbe, 2014
Inflammasome-mediated host defenses have been extensively studied in innate immune cells. Whether inflammasomes function for innate defense in intestinal epithelial cells, which represent the first line of defense against enteric pathogens, remains unknown.
Knodler, Leigh A, Crowley, Shauna M, Sham, Ho Pan, Yang, Hyungjun, Wrande, Marie, Ma, Caixia, Ernst, Robert K, Steele-Mortimer, Olivia, Celli, Jean, Vallance, Bruce A   +9 more
openaire   +3 more sources

Function and Regulation of Noncanonical Caspase-4/5/11 Inflammasome [PDF]

The Journal of Immunology, 2020
Abstract Inflammasomes are multiprotein complexes of the innate immune system that orchestrate development of inflammation by activating the secretion of proinflammatory cytokines, IL-1β and IL-18. The LPS of Gram-negative bacteria have been shown to activate a novel, noncanonical inflammasome by directly binding in the cytosol to human ...
Sampsa Matikainen, Tuula A Nyman, Wojciech Cypryk   +2 more
openaire   +3 more sources

Evidence for Two Modes of Synergistic Induction of Apoptosis by Mapatumumab and Oxaliplatin in Combination with Hyperthermia in Human Colon Cancer Cells [PDF]

, 2013
Colorectal cancer is the third leading cause of cancer-related mortality in the world-- the main cause of death from colorectal cancer is hepatic metastases, which can be treated with isolated hepatic perfusion (IHP).
A Jemal, A Krueger, A Krueger, A Younes, AR Safa, BR Seo, C Liu, C Odoux, CH Mom, D Atallah, D Mahalingam, DB Longley, E Raymond, FA Greco, GJ Ullenhag, HJ Zeh 3rd, HR Alexander Jr., IA Mawji, IN Lavrik, J Yoo, JA Ubersax, JM Cummins, JW Yu, L Zhang, L Zhao, LR Hafström, LY Dimberg, M Irmler, M Upreti, M Vulfovich, MA Alcala Jr., MJ Lee, P Korkolopoulou, Raffaele A Calogero, S Hegewisch-Becker, S Varghese, Seog-Young Kim, SK Libutti, T Bartke, T Ruers, T Trarbach, TR Wilson, W Gao, X Song, X Song, X Song, Xinxin Song, Y Jin-Song, Y Lin, YJ Lee, YL Zhang, Yong J. Lee, Z El Fajoui   +52 more
core   +17 more sources

Caspase-mediated Specific Cleavage of Human Histone Deacetylase 4 [PDF]

Journal of Biological Chemistry, 2004
Histone deacetylase 4 (HDAC4) is a class II HDAC implicated in controlling gene expression important for diverse cellular functions, but little is known about how its expression and stability are regulated. We report here that this deacetylase is unusually unstable, with a half-life of less than 8 h.
Fang, Liu, Melissa, Dowling, Xiang-Jiao, Yang, Gary D, Kao   +3 more
openaire   +2 more sources

Caspase-dependent apoptosis by ectopic expression of E2F-4 [PDF]

Oncogene, 2000
E2F is a family of transcription factors which regulates cell cycle and apoptosis of mammalian cells. E2F-1-3 localize in the nucleus, and preferentially bind pRb, while E2F-4 and 5 have no nuclear localization signal and preferentially bind p107/p130. E2F-6 suppresses the transcriptional activity of other E2F proteins.
Y C, Chang, H, Nakajima, S, Illenye, Y S, Lee, N, Honjo, T, Makiyama, I, Fujiwara, N, Mizuta, K, Sawai, K, Saida, Y, Mitsui, N H, Heintz, J, Magae   +12 more
openaire   +2 more sources

Caspase-4 disaggregates lipopolysaccharide micelles via LPS-CARD interaction [PDF]

Scientific Reports, 2019
AbstractLipopolysaccharides (LPS) are a major component of the outer membrane of Gram-negative bacteria and are pathogen-associated molecular patterns recognized by the TLR4/MD2 complex that induces an inflammatory response. Recently, the cytosolic receptors caspase-4/-5/-11 that bind LPS inside the cell and trigger inflammasome activation or ...
Jinsu An, Seong Ho Kim, Dohyeon Hwang, Kyung Eun Lee, Min Jung Kim, Eun Gyeong Yang, So Yeon Kim, Hak Suk Chung   +7 more
openaire   +2 more sources

Spotlight on pyroptosis: role in pathogenesis and therapeutic potential of ocular diseases

Journal of Neuroinflammation, 2022
Pyroptosis is a programmed cell death characterized by swift plasma membrane disruption and subsequent release of cellular contents and pro-inflammatory mediators (cytokines), including IL‐1β and IL‐18.
Meini Chen, Rong Rong, Xiaobo Xia
doaj   +1 more source

The endogenous caspase-8 inhibitor c-FLIPL regulates ER morphology and crosstalk with mitochondria [PDF]

, 2014
Components of the death receptors-mediated pathways like caspase-8 have been identified in complexes at intracellular membranes to spatially restrict the processing of local targets.
A Filippini, A Golks, AV Nikonov, C Cerqua, C Frezza, C Giampietri, C Giampietri, C Giorgi, C Scaffidi, D Chandra, D Ferrari, DG Breckenridge, DG Breckenridge, E Area-Gomez, E S Marini, E Zampese, E Ziparo, EM Manders, F Gonzalvez, FW Ng, G Grynkiewicz, G Orso, GK Voeltz, I Sparkes, J Hu, J Zhang, JE Vance, JR Friedman, KH Shain, L Jozsef, L Scorrano, M Irmler, M Li, MJ Dayel, N Myhill, N Wittkopf, OM de Brito, OM de Brito, R Katayama, R Rizzuto, R Rizzuto, R Schweigreiter, R Xiang, RS Misra, S Conti, S Petrungaro, SH Park, T Simmen, TW Day, WC Yeh, Y Shibata, Y Shibata, Y Shibata, ZT Schug   +53 more
core   +2 more sources