Results 11 to 20 of about 153 (95)

The recombinant pseudorabies virus expressing African swine fever virus CD2v protein is safe and effective in mice [PDF]

Virology Journal, 2020
Background African swine fever (ASF) leads to high mortality in domestic pigs and wild boar and is caused by the African swine fever virus (ASFV). Currently, no vaccine is commercially available for prevention, and the epidemic is still spreading.
Zhihua Feng, Jianghua Chen, Wangwang Liang, Wenzhi Chen, Zhaolong Li, Qi Chen, Shaoli Cai   +6 more
doaj   +3 more sources

Development of a Dual ELISA for the Detection of CD2v-Unexpressed Lower-Virulence Mutational ASFV [PDF]

Life, 2021
African swine fever virus (ASFV) is an important viral pathogen infecting pigs worldwide throughout the pig industry. CD2v (an outer-membrane glycosylated protein of ASFV)-unexpressed lower-virulence mutants have appeared in China and other countries in ...
Changjie Lv, Ya Zhao, Lili Jiang, Li Zhao, Chao Wu, Xianfeng Hui, Xiaotong Hu, Ziqi Shao, Xiaohan Xia, Xiaomei Sun, Qiang Zhang, Meilin Jin   +11 more
doaj   +3 more sources

Identification of a new cell-penetrating peptide derived from the african swine fever virus CD2v protein [PDF]

Drug Delivery, 2021
The African swine fever virus (ASFV) is a huge and complex DNA virus that can lead to the acute death of pigs and cause huge losses to the global swine industry.
Shunli Yang, Xinming Zhang, Yuying Cao, Shuo Li, Junjun Shao, Shiqi Sun, Huichen Guo, Shuanghui Yin   +7 more
doaj   +3 more sources

Generation and Evaluation of an African Swine Fever Virus Mutant with Deletion of the CD2v and UK Genes

Vaccines, 2020
African swine fever (ASF) is a highly contagious and often lethal disease caused by African swine fever virus (ASFV). ASF emerged in China in August 2018 and has since rapidly spread into many areas of the country.
Teshale Teklue, Tao Wang, Yuzi Luo, Rongliang Hu, Yuan Sun, Hua-Ji Qiu   +5 more
doaj   +3 more sources

Identification of Two Novel Linear B Cell Epitopes on the CD2v Protein of African Swine Fever Virus Using Monoclonal Antibodies

Viruses, 2022
African swine fever virus (ASFV) is a highly infectious viral pathogen that endangers the global pig industry, and no effective vaccine is available thus far.
Wenting Jiang, Dawei Jiang, Lu Li, Jiabin Wang, Panpan Wang, Xuejian Shi, Qi Zhao, Boyuan Liu, Pengchao Ji, Gaiping Zhang   +9 more
doaj   +3 more sources

A protective multiple gene-deleted African swine fever virus genotype II, Georgia 2007/1, expressing a modified non-haemadsorbing CD2v protein

Emerging Microbes and Infections, 2023
African swine fever virus is a complex DNA virus that causes high fatality in pigs and wild boar and has a great socio-economic impact. An attenuated genotype II strain was constructed by replacing the gene for wildtype CD2v protein with versions in ...
Anusyah Rathakrishnan, Ana L. Reis, Vlad Petrovan, Lynnette C. Goatley, Katy Moffat, Yuan Lui, Mai T. Vuong, Shinji Ikemizu, Simon J. Davis, Linda K. Dixon   +9 more
doaj   +3 more sources

ASF virus replication features in the presence of recombinant proteins CD2v, pX69R and pE248R

Вопросы вирусологии, 2019
Introduction. African swine fever (ASF), sever hemorrhagic disease of swine caused by a large DNA virus of the Asfaviridae family. Since there are no effective and safe vaccines against ASF yet, it is urgent to study the functions of its proteins, which ...
A. Mazloum, I. U. Zhukov, E. B. Aronova, A. S. Igolkin, N. N. Vlasova   +4 more
doaj   +4 more sources

Deletion of the CD2v Gene from the Genome of ASFV-Kenya-IX-1033 Partially Reduces Virulence and Induces Protection in Pigs

Viruses, 2022
Infection of pigs with the African swine fever virus (ASFV) leads to a devastating hemorrhagic disease with a high mortality of up to 100%. In this study, a CD2v gene deletion was introduced to a genotype IX virus from East Africa, ASFV-Kenya-IX-1033 ...
Johanneke D. Hemmink, Emmanuel M. Khazalwa, Hussein M. Abkallo, Bernard Oduor, Jeremiah Khayumbi, Nicholas Svitek, Sonal P. Henson, Sandra Blome, Günther Keil, Richard P. Bishop, Lucilla Steinaa   +10 more
doaj   +4 more sources

Development and Application of Mouse-Derived CD2v Monoclonal Antibodies Against African Swine Fever Virus from Single B Cells

Viruses
African swine fever (ASF) is a highly pathogenic and hemorrhagic swine infectious disease caused by the African swine fever virus (ASFV). It encodes over 150 proteins, among which the CD2v protein plays multiple roles throughout the infection process ...
Litao Yu, Fangtao Li, Xingqi Zou, Lu Xu, Junjie Zhao, Yan Li, Guorui Peng, Yingju Xia, Qizu Zhao, Yuanyuan Zhu   +9 more
doaj   +2 more sources

Computational insights in CD58 binding to ASFV CD2v and in silico optimization of nanobody designs against the interface

Open Veterinary Journal
Background: African swine fever (ASF) continues to hamper pork production worldwide. In addition to vaccines, there is a need to develop curative therapeutics, such as highly-specific antibodies or nanobodies, against immunogenic proteins with important
Albert Neil Gura Dulay, Richelle Mae Evasco Padilla, Nyzar Mabeth Obenio Odchimar, Fredmoore Legaspi Orosco   +3 more
doaj   +3 more sources