Results 31 to 40 of about 644 (132)

Identification of Two Novel Linear B Cell Epitopes on the CD2v Protein of African Swine Fever Virus Using Monoclonal Antibodies

Viruses, 2022
African swine fever virus (ASFV) is a highly infectious viral pathogen that endangers the global pig industry, and no effective vaccine is available thus far.
Wenting Jiang, Dawei Jiang, Lu Li, Jiabin Wang, Panpan Wang, Xuejian Shi, Qi Zhao, Boyuan Liu, Pengchao Ji, Gaiping Zhang   +9 more
doaj   +3 more sources

Comparisons on soluble expression and immunoreactivity of African swine fever virus CD2v protein expressed by different prokaryotic expression vectors

浙江大学学报. 农业与生命科学版, 2023
The aim of this study was to systematically investigate the differences in the soluble expression level of the African swine fever virus (ASFV) CD2v protein by different prokaryotic expression vectors, and the immunoreactivities of the inclusion body and
FENG Mengke, WANG Xingbo, LIN Lulu, CUI Mingxian, YAN Yan, ZHOU Jiyong   +5 more
doaj   +2 more sources

The CD2v protein of African swine fever virus inhibits macrophage migration and inflammatory cytokines expression by downregulating EGR1 expression through dampening ERK1/2 activity

Veterinary Research, 2023
African swine fever virus (ASFV) is a highly contagious and deadly virus that leads to high mortality rates in domestic swine populations. Although the envelope protein CD2v of ASFV has been implicated in immunomodulation, the molecular mechanisms ...
Min Zhang, Lilei Lv, Huaye Luo, Hongming Cai, Lingxue Yu, Yifeng Jiang, Fei Gao, Wu Tong, Liwei Li, Guoxin Li, Yanjun Zhou, Guangzhi Tong, Changlong Liu   +12 more
doaj   +3 more sources

Nanobodies against African swine fever virus p72 and CD2v proteins as reagents for developing two cELISAs to detect viral antibodies [PDF]

Virologica Sinica
African swine fever virus (ASFV) poses a significant threat to the global swine industry. Currently, there are no effective vaccines or treatments available to combat ASFV infection in pigs. The primary means of controlling the spread of the disease is through rapid detection and subsequent elimination of infected pig.
Qin Zhao
exaly   +4 more sources

A Pool of Ferritin Nanoparticles Delivering Six Proteins of African Swine Fever Virus Induces Robust Humoral and Cellular Immune Responses in Pigs [PDF]

Vaccines
Background/Objectives: Inadequate characterization of protective antigens poses a significant challenge to the development of vaccines for African swine fever (ASF), particularly for antigen-dependent formulations such as subunit, mRNA, and recombinant ...
Zhanhao Lu, Dailang Zhong, Xin Song, Jing Lan, Yanjin Wang, Rui Luo, Shengmei Chen, Ruojia Huang, Hua-Ji Qiu, Yongfeng Li, Tao Wang, Yuan Sun   +11 more
doaj   +2 more sources

Subsequent Immunization of Pigs with African Swine Fever Virus (ASFV) Seroimmunotype IV Vaccine Strain FK-32/135 and by Recombinant Plasmid DNA Containing the CD2v Derived from MK-200 ASFV Seroimmunotype III Strain Does Not Protect from Challenge with ASFV Seroimmunotype III

Vaccines, 2023
Understanding the immunological mechanisms of protection and the viral proteins involved in the induction of a protective immune response to the African swine fever virus (ASFV) is still limited.
Anna S Kazakova, Irina P Sindryakova, Denis Kolbasov   +2 more
exaly   +3 more sources

A triple protein-based ELISA for differential detection of ASFV antibodies [PDF]

Frontiers in Veterinary Science
African swine fever (ASF) caused by the ASF virus (ASFV) is a severe and highly contagious viral disease that poses a significant threat to the global pig industry.
Shuai Zhang, Yuzhu Zuo, Wenyuan Gu, Yunhuan Zhao, Ying Liu, Jinghui Fan, Jinghui Fan   +6 more
doaj   +2 more sources

Development and efficacy of a novel mRNA cocktail for the delivery of African swine fever virus antigens and induction of immune responses [PDF]

Microbiology Spectrum
African swine fever (ASF) is a highly lethal infectious disease affecting pigs. Although several vaccine formulations have been developed to protect from ASF virus (ASFV) infection, none have yet provided complete protection without side effects or the ...
Xing Hu, Cong Liu, Nino Rcheulishvili, Yunzhi Wang, Ting Xiong, Fengfei Xie, Xingyun Wang, Ruiai Chen, Peng George Wang, Yunjiao He   +9 more
doaj   +2 more sources

Construction and Evaluation of Quadruple-Gene-Deleted Pseudorabies Virus Platforms for ASFV Antigen Delivery. [PDF]

Transbound Emerg Dis
African Swine Fever (ASF) is a highly lethal viral disease in swine. The emergence and rapid spread of African Swine Fever virus (ASFV) in China, since 2018 have caused significant economic losses to the pig farming industry. The complexity of ASFV has impeded the development of effective vaccines, and with no commercial vaccines currently available in
Li H, Guo R, Jia Y, Zhang X, Liu Z, Shi W, Hu R, Zhang Y, Nasir S, Han L, Qiu X, Wang X.   +11 more
europepmc   +2 more sources

Generation and Characterization of Recombinant Pseudorabies Virus Delivering African Swine Fever Virus CD2v and p54. [PDF]

Int J Mol Sci, 2023
African swine fever (ASF) leads to high mortality in domestic pigs and wild boar, and it is caused by the African swine fever virus (ASFV). Currently, no commercially available vaccine exists for its prevention in China. In this study, we engineered a pseudorabies recombinant virus (PRV) expressing ASFV CD2v and p54 proteins (PRV-∆TK-(CD2v)-∆gE-(p54 ...
Wei J, Liu C, He X, Abbas B, Chen Q, Li Z, Feng Z.   +6 more
europepmc   +3 more sources