Development of novel monoclonal antibodies for blocking NF-κB activation induced by CD2v protein in African swine fever virus [PDF]
Frontiers in ImmunologyBackgroundCD2v, a critical outer envelope glycoprotein of the African swine fever virus (ASFV), plays a central role in the hemadsorption phenomenon during ASFV infection and is recognized as an essential immunoprotective protein.
Rongrong Fan +19 more
exaly +6 more sources
Microbiology Spectrum, 2022 The CD2-like (CD2V) protein is a crucial antigen of African swine fever virus (ASFV). CD2V interacts with the cellular AP-1 protein, participates in intracellular transport of virus, and induces neutralizing antibodies to partly protect swine from virus ...
Rui Jia, Gaiping Zhang, Aiping Wang
exaly +5 more sources
CD2v Interacts with Adaptor Protein AP-1 during African Swine Fever Infection [PDF]
PLoS ONE, 2015 African swine fever virus (ASFV) CD2v protein is believed to be involved in virulence enhancement, viral hemadsorption, and pathogenesis, although the molecular mechanisms of the function of this viral protein are still not fully understood.
Daniel Pérez-Núñez
exaly +8 more sources
African Swine Fever Virus CD2v Protein Induces β-Interferon Expression and Apoptosis in Swine Peripheral Blood Mononuclear Cells [PDF]
Viruses, 2021 African swine fever (ASF) is a hemorrhagic disease of swine characterized by massive lymphocyte depletion in lymphoid tissues due to the apoptosis of B and T cells, a process likely triggered by factors released or secreted by infected macrophages.
Sabal Chaulagain +3 more
exaly +5 more sources
Identification of a new cell-penetrating peptide derived from the african swine fever virus CD2v protein [PDF]
Drug Delivery, 2021 The African swine fever virus (ASFV) is a huge and complex DNA virus that can lead to the acute death of pigs and cause huge losses to the global swine industry.
Shunli Yang, Shiqi Sun, Shuanghui yin
exaly +4 more sources
Frontiers in Veterinary Science, 2022 African swine fever (ASF) is a potent infectious disease with detrimental effects on the global swine industry and no currently vaccine available. The emergence of low-virulence CD2v-deleted mutants manifested as non-hemadsorption (non-HAD) strains ...
Wenting Jiang +28 more
exaly +5 more sources
Development and Application of Mouse-Derived CD2v Monoclonal Antibodies Against African Swine Fever Virus from Single B Cells [PDF]
VirusesAfrican swine fever (ASF) is a highly pathogenic and hemorrhagic swine infectious disease caused by the African swine fever virus (ASFV). It encodes over 150 proteins, among which the CD2v protein plays multiple roles throughout the infection process ...
Litao Yu +9 more
doaj +3 more sources
The recombinant pseudorabies virus expressing African swine fever virus CD2v protein is safe and effective in mice [PDF]
Virology Journal, 2020 Background African swine fever (ASF) leads to high mortality in domestic pigs and wild boar and is caused by the African swine fever virus (ASFV). Currently, no vaccine is commercially available for prevention, and the epidemic is still spreading.
Zhihua Feng
exaly +5 more sources
Frontiers in Microbiology, 2022 African swine fever virus (ASFV), a DNA double-stranded virus with high infectivity and mortality, causing a devastating blow to the pig industry and the world economy. The CD2v protein is an essential immunoprotective protein of ASFV.
Siyuan Liu +16 more
exaly +5 more sources
Screening of host proteins interacting with the African swine fever virus outer membrane protein CD2v [PDF]
Frontiers in MicrobiologyBackgroundThe African swine fever virus (ASFV) is a highly pathogenic double-stranded DNA virus that poses a significant threat to the global swine industry.
Xiong-nan Chen +32 more
doaj +3 more sources