Emerging Microbes and Infections, 2023 African swine fever virus is a complex DNA virus that causes high fatality in pigs and wild boar and has a great socio-economic impact. An attenuated genotype II strain was constructed by replacing the gene for wildtype CD2v protein with versions in ...
Ana Luisa Reis +2 more
exaly +5 more sources
Computational insights in CD58 binding to ASFV CD2v and in silico optimization of nanobody designs against the interface [PDF]
Open Veterinary JournalBackground: African swine fever (ASF) continues to hamper pork production worldwide. In addition to vaccines, there is a need to develop curative therapeutics, such as highly-specific antibodies or nanobodies, against immunogenic proteins with important
Albert Neil Gura Dulay +3 more
doaj +4 more sources
From structure prediction to function: defining the domain on the African swine fever virus CD2v protein required for binding to erythrocytes [PDF]
mBioAfrican swine fever virus (ASFV) is a high-consequence pathogen posing a substantial threat to global food security. This large DNA virus encodes more than 150 open reading frames, many of which are uncharacterized.
Ana Luisa Reis +10 more
doaj +4 more sources
Viruses, 2022 Infection of pigs with the African swine fever virus (ASFV) leads to a devastating hemorrhagic disease with a high mortality of up to 100%. In this study, a CD2v gene deletion was introduced to a genotype IX virus from East Africa, ASFV-Kenya-IX-1033 ...
Johanneke D Hemmink +2 more
exaly +6 more sources
An attenuated African swine fever virus with deletions of the CD2v and A137R genes offers complete protection against homologous challenge in pigs [PDF]
Journal of VirologyAfrican swine fever (ASF) has caused a devastating pandemic among domestic and wild swine, leading to significant economic losses in the global swine industry. Recombinant live-attenuated vaccines are a potential option for the control of ASF.
Guorui Peng +17 more
doaj +3 more sources
Vaccines, 2022 African swine fever (ASF) is an obligated declaration swine disease, provoking farm isolation measures and the closing of affected country boarders. ASF virus (ASFV) is currently the cause of a pandemic across China and Eurasia.
Daniel Pérez-Núñez +2 more
exaly +5 more sources
An Intracellular Epitope of ASFV CD2v Protein Elicits Humoral and Cellular Immune Responses
Animals, 2023 The African swine fever virus (ASFV) causes high mortality in domestic pigs. ASFV encodes an important protein target for subunit vaccine development, CD2v, but its most effective immunological regions are not known.
Wenlong Lu +11 more
doaj +3 more sources
The ASFV CD2v protein inhibits apoptosis by inducing proteasomal degradation of BimEL via activation of the TPL2-MEK-ERK signaling pathway [PDF]
Journal of VirologyAfrican swine fever virus (ASFV) employs sophisticated regulatory strategies to manipulate host cell apoptosis, a process critical for its pathogenesis and immune evasion; however, the mechanisms underlying this process remain incompletely understood ...
Jianyu Zeng +15 more
doaj +2 more sources
Development of a Dual ELISA for the Detection of CD2v-Unexpressed Lower-Virulence Mutational ASFV [PDF]
Life, 2021 African swine fever virus (ASFV) is an important viral pathogen infecting pigs worldwide throughout the pig industry. CD2v (an outer-membrane glycosylated protein of ASFV)-unexpressed lower-virulence mutants have appeared in China and other countries in ...
Changjie Lv +11 more
doaj +3 more sources
Vaccines, 2020 African swine fever (ASF) is a highly contagious and often lethal disease caused by African swine fever virus (ASFV). ASF emerged in China in August 2018 and has since rapidly spread into many areas of the country.
Teshale Teklue +5 more
doaj +3 more sources