Results 21 to 30 of about 153 (95)

Screening of host proteins interacting with the African swine fever virus outer membrane protein CD2v

Frontiers in Microbiology
BackgroundThe African swine fever virus (ASFV) is a highly pathogenic double-stranded DNA virus that poses a significant threat to the global swine industry.
Xiong-nan Chen, Xiong-nan Chen, Xiong-nan Chen, Gao-xi Zhu, Gao-xi Zhu, Gao-xi Zhu, Yi-xian Li, Yi-han Hao, Yi-han Hao, Yi-han Hao, Yi-fan Liang, Yi-fan Liang, Chen Hu, Ying-shuo Sun, Ying-shuo Sun, Yun-zhao Peng, Yun-zhao Peng, Xi Li, Xi Li, Xi Li, Zhao Huang, Zhao Huang, Zhao Huang, Gui-hong Zhang, Gui-hong Zhang, Gui-hong Zhang, Lang Gong, Lang Gong, Lang Gong, Ze-zhong Zheng, Ze-zhong Zheng, Ze-zhong Zheng, Ze-zhong Zheng   +32 more
doaj   +2 more sources

Development of novel monoclonal antibodies for blocking NF-κB activation induced by CD2v protein in African swine fever virus

Frontiers in Immunology
BackgroundCD2v, a critical outer envelope glycoprotein of the African swine fever virus (ASFV), plays a central role in the hemadsorption phenomenon during ASFV infection and is recognized as an essential immunoprotective protein.
Rongrong Fan, Rongrong Fan, Zeliang Wei, Zeliang Wei, Zeliang Wei, Mengmeng Zhang, Shanshan Jia, Zhiyang Jiang, Yao Wang, Junyu Cai, Junyu Cai, Guojiang Chen, He Xiao, Yinxiang Wei, Yanchun Shi, Jiannan Feng, Beifen Shen, Yuanqiang Zheng, Yaojiang Huang, Jing Wang   +19 more
doaj   +3 more sources

From structure prediction to function: defining the domain on the African swine fever virus CD2v protein required for binding to erythrocytes

mBio
African swine fever virus (ASFV) is a high-consequence pathogen posing a substantial threat to global food security. This large DNA virus encodes more than 150 open reading frames, many of which are uncharacterized.
Ana Luisa Reis, Anusyah Rathakrishnan, Vlad Petrovan, Muneeb Islam, Lynnette Goatley, Katy Moffat, Mai Tuyet Vuong, Yuan Lui, Simon J. Davis, Shinji Ikemizu, Linda K. Dixon   +10 more
doaj   +3 more sources

Recombinant African Swine Fever Virus Arm/07/CBM/c2 Lacking CD2v and A238L Is Attenuated and Protects Pigs against Virulent Korean Paju Strain

Vaccines, 2022
African swine fever (ASF) is an obligated declaration swine disease, provoking farm isolation measures and the closing of affected country boarders. ASF virus (ASFV) is currently the cause of a pandemic across China and Eurasia.
Daniel Pérez-Núñez, Sun-Young Sunwoo, Raquel García-Belmonte, Chansong Kim, Gonzalo Vigara-Astillero, Elena Riera, Dae-min Kim, Jiyun Jeong, Dongseob Tark, Young-Seung Ko, Young-Kook You, Yolanda Revilla   +11 more
doaj   +3 more sources

An attenuated African swine fever virus with deletions of the CD2v and A137R genes offers complete protection against homologous challenge in pigs

Journal of Virology
African swine fever (ASF) has caused a devastating pandemic among domestic and wild swine, leading to significant economic losses in the global swine industry. Recombinant live-attenuated vaccines are a potential option for the control of ASF.
Guorui Peng, Xin Zhao, Xingqi Zou, He Zhang, Junjie Zhao, Xuezhi Zuo, Shuguang Tan, Ruizhi Wu, Xue Guan, Shihua Li, Yuan Xu, Yingju Xia, Xiaoai Xu, Lu Xu, Yuanyuan Zhu, Jinhua Liu, Yebing Liu, George Fu Gao   +17 more
doaj   +2 more sources

Processing and Localization of the African Swine Fever Virus CD2v Transmembrane Protein [PDF]

Journal of Virology, 2011
ABSTRACTThe African swine fever virus (ASFV)-encoded CD2v transmembrane protein is required for the hemadsorption of red blood cells around infected cells and is also required for the inhibition of bystander lymphocyte proliferation in response to mitogens.
Lynnette C, Goatley, Linda K, Dixon
openaire   +2 more sources

Identification of a linear B-cell epitope on the African swine fever virus CD2v protein

International Journal of Biological Macromolecules, 2023
African swine fever virus (ASFV) poses a serious threat to domestic pigs and wild boars, which is responsible for substantial production and economic losses. A dominant ASFV specific linear B cell epitope that reacted with the convalescent serum was explored and identified with the help of immune informatics techniques. It is essential in understanding
Jinxing, Song, Mengxiang, Wang, Yongkun, Du, Bo, Wan, Angke, Zhang, Yuhang, Zhang, Guoqing, Zhuang, Pengchao, Ji, Yanan, Wu, Gaiping, Zhang   +9 more
openaire   +2 more sources

Generation and Characterization of Recombinant Pseudorabies Virus Delivering African Swine Fever Virus CD2v and p54

International Journal of Molecular Sciences, 2023
African swine fever (ASF) leads to high mortality in domestic pigs and wild boar, and it is caused by the African swine fever virus (ASFV). Currently, no commercially available vaccine exists for its prevention in China. In this study, we engineered a pseudorabies recombinant virus (PRV) expressing ASFV CD2v and p54 proteins (PRV-∆TK-(CD2v)-∆gE-(p54 ...
Jianhui Wei, Chuancheng Liu, Xinyan He, Bilal Abbas, Qi Chen, Zhaolong Li, Zhihua Feng   +6 more
openaire   +2 more sources

Identification of T-cell epitopes in African swine fever virus CD2v and C-type lectin proteins [PDF]

Journal of General Virology, 2019
African swine fever (ASF) is an emerging disease threat for the swine industry worldwide. No ASF vaccine is available, and progress is hindered by lack of knowledge concerning the extent of ASF virus (ASFV) strain diversity and the viral antigens conferring type-specific protective immunity in pigs.
Burmakina, Galina, Malogolovkin, Alexander, Tulman, Edan R, Xu, Weidong, Delhon, Gustavo, Kolbasov, Denis, Rock, Daniel L   +6 more
openaire   +2 more sources

Signal peptide and N-glycosylation of N-terminal-CD2v determine the hemadsorption of African swine fever virus

Journal of Virology, 2023
ABSTRACT African swine fever virus (ASFV) is the cause of African swine fever (ASF), a devastating disease that affects domestic pigs and wild boar and is currently responsible for the largest animal epidemic. One of the characteristics of ASFV infection, but absent in naturally attenuated strains, is hemadsorption (HAD), a phenomenon that ...
Daniel Pérez-Núñez, Raquel García-Belmonte, Elena Riera, Marta H. Fernández-Sesma, Gonzalo Vigara-Astillero, Yolanda Revilla   +5 more
openaire   +3 more sources