Results 111 to 120 of about 11,198,861 (420)

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

Molecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu, Jianchao Wang, Fuqing Chen, Xuefeng Wang, Bin Lan, Ruyi Fu, Hong Wen, Fangfang Chen, Wei Hong, Tian‐Yu Tang, Ying He, Gang Chen, Jianyin Zhou, Hai‐Long Piao, Di Chen, Shu‐Yong Lin   +15 more
wiley   +1 more source

Cell lineage tracing reveals the plasticity of the hemocyte lineages and of the hematopoietic compartments in Drosophila melanogaster [PDF]

, 2010
Much of our knowledge on hematopoiesis, hematopoietic compartments, hematopoietic cell lineages and immunity has been derived from studies on the vertebrate immune system.
Brehélin, Crozatier, Ferenc Jankovics, Goto, Gábor Csordás, Hedengren, Holz, Honti, Hultmark, István Andó, Ito, Jankovics, Kimbrell, Krzemień, Kurucz, Kurucz, Kurucz, Lanot, Lebestky, Mandal, Márkus, Nappi, Olofsson, Rizki, Rizki, Russo, Róbert Márkus, Shrestha, Sorrentino, Stramer, Tokusumi, Viktor Honti, Zettervall, Éva Kurucz   +33 more
core   +1 more source

CDK14 regulates the development and repair of lung

Cell Death Discovery
Cyclin-dependent kinases (CDK) 14 regulates cell cycle, tumor expansion by influencing the downstream targets of the canonical Wnt signaling pathway. However, the function of CDK14 during organ development and regeneration has not been investigated in ...
Jian-wei Chen, Yu-xiang Wang, Rong-rong Gao, Lan-yue Ma, Jing Zhong, Jia-xin Yang, Zhao-hua Deng, Yu-yan Li, Xiao-ling Li, Ya-hai Shu, Wen-jing Guo, Zi-yuan Zhou, Xiao Yu Tian, Jinjin Ma, Yang Liu, Qi Chen   +15 more
doaj   +1 more source

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

Robust Lineage Reconstruction from High-Dimensional Single-Cell Data [PDF]

arXiv, 2016
Single-cell gene expression data provide invaluable resources for systematic characterization of cellular hierarchy in multi-cellular organisms. However, cell lineage reconstruction is still often associated with significant uncertainty due to technological constraints. Such uncertainties have not been taken into account in current methods.
arxiv  

Towards a digital model of zebrafish embryogenesis. Integration of Cell Tracking and Gene Expression Quantification [PDF]

, 2010
We elaborate on a general framework composed of a set of computational tools to accurately quantificate cellular position and gene expression levels throughout early zebrafish embryogenesis captured over a time-lapse series of in vivo 3D images.
Bourgine, Paul, Castro González, Carlos, Desnoulez, Sophie, Douloquin, Louise, Ledesma Carbayo, María Jesús, Luengo Oroz, Miguel Ángel, Melani, Camilo, Peyrieras, Nadine, Santos Lleo, Andres de, Savy, Thierry   +9 more
core   +1 more source

Single-Cell Transcriptomic Profiling of Pluripotent Stem Cell-Derived SCGB3A2+ Airway Epithelium. [PDF]

, 2018
Lung epithelial lineages have been difficult to maintain in pure form in vitro, and lineage-specific reporters have proven invaluable for monitoring their emergence from cultured pluripotent stem cells (PSCs).
Alysandratos, Konstantinos-Dionysios, Caballero, Ignacio S, Carraro, Gianni, Guttentag, Susan H, Hawkins, Finn, Jacob, Anjali, Kook, Seunghyi, Kotton, Darrell N, McCauley, Katherine B, Morley, Michael, Morrisey, Edward E, Slovik, Katherine J, Stripp, Barry R, Vedaie, Marall, Yang, Wenli   +14 more
core   +2 more sources

Cell Lineage Determination in the Mouse.

Cell Structure and Function, 2001
During the peri-implantation development of the mouse embryo from the blastocyst through gastrulation, Pou5f1 (OCT-4) down-regulation is closely linked to the initial step of lineage allocation to extraembryonic and embryonic somatic tissues. Subsequently, differentiation of the lineage precursors is subject to inductive tissue interactions and ...
Patrick P.L. Tam, Catherine M. Watson
openaire   +4 more sources

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

Molecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair, Philip König, Milena Mijović, Jessica Kalla, Anil Baskan, Loan Tran, Kristina Draganić, Pedro Morata Saldaña, Carlos Uziel Pérez Malla, Janette Pfneissl, Andreas Tiefenbacher, Julijan Kabiljo, Velina S. Atanasova, Lisa Wozelka‐Oltjan, Leonhard Müllauer, Michael Bergmann, Raheleh Sheibani‐Tezerji, Gerda Egger   +17 more
wiley   +1 more source

Distribution of neurosensory progenitor pools during inner ear morphogenesis unveiled by cell lineage reconstruction

eLife, 2017
Reconstructing the lineage of cells is central to understanding how the wide diversity of cell types develops. Here, we provide the neurosensory lineage reconstruction of a complex sensory organ, the inner ear, by imaging zebrafish embryos in vivo over ...
Sylvia Dyballa, Thierry Savy, Philipp Germann, Karol Mikula, Mariana Remesikova, Róbert Špir, Andrea Zecca, Nadine Peyriéras, Cristina Pujades   +8 more
doaj   +1 more source