Results 1 to 10 of about 5,964 (133)

Opossum carboxylesterases: sequences, phylogeny and evidence for CES gene duplication events predating the marsupial-eutherian common ancestor [PDF]

BMC Evolutionary Biology, 2008
Background Carboxylesterases (CES) perform diverse metabolic roles in mammalian organisms in the detoxification of a broad range of drugs and xenobiotics and may also serve in specific roles in lipid, cholesterol, pheromone and lung surfactant metabolism.
Chan Jeannie, Holmes Roger S, Cox Laura A, Murphy William J, VandeBerg John L   +4 more
doaj   +5 more sources

CES1 Increases Hepatic Triacylglycerol Synthesis Through Activation of PPARγ, LXR and SREBP1c [PDF]

Cells
Increased hepatic triacylglycerol (TG) storage in lipid droplets (LDs) is a hallmark of metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis (MASH).
Rajakumar Selvaraj, Jihong Lian, Russell Watts, Randal Nelson, Michael F. Saikali, Carolyn L. Cummins, Richard Lehner   +6 more
doaj   +2 more sources

The role of ABCB1 and CES1 genotypes on the efficacy and safety of dabigatran: a systematic review and meta-analysis [PDF]

Human Genomics
Introduction : Dabigatran is a direct oral anticoagulant associated with a high incidence of gastrointestinal bleeding, which presents a significant clinical concern.
Weam Aldiban, Nada G. Hamam, Nereen A. Almosilhy, Kholoud Elsamman, Mohamed Wagdy, Doaa Mashaly, Suhel F. Batarseh, Youssef El-Sherif, Basma Badrawy Khalefa, Zina Otmani   +9 more
doaj   +2 more sources

Hypercholesterolemia and the role of lipid metabolism gene CES1 in immune infiltration promote central nervous system relapse in acute myeloid leukemia [PDF]

Frontiers in Immunology
BackgroundAlterations in multiple lipid metabolism pathways are associated with cancer progression. However, the relationship between lipid metabolism and central nervous system (CNS) relapse in acute myeloid leukemia (AML) remains unclear.MethodsWe ...
Wanwan Bao, Wanwan Bao, Yansong Tu, Shan Zhang, Shan Zhang, Xiaoyan Jiang, Huijun Chen, Huaijun Tu, Jian Li   +8 more
doaj   +2 more sources

Carboxylesterase 1-mediated endocannabinoid metabolism in skin: role in melanoma progression in BRaf V600E /Pten −/− mice [PDF]

Cancer & Metabolism
Background Melanoma is a highly aggressive skin cancer with a poor prognosis. The endocannabinoids 2-arachidonoylgylcerol (2-AG) and anandamide have been linked to melanoma progression, though their roles remain unclear.
Veronika Morozova, Daniele Pellegata, Roch-Philippe Charles, Jürg Gertsch   +3 more
doaj   +2 more sources

Effects of exercise and walnut oil on CES1 and inflammatory factors in the liver of type 2 diabetic rats [PDF]

European Journal of Medical Research
Carboxylesterase 1 (CES1) and inflammatory factors play important roles in regulating lipid metabolism and maintaining glucose homeostasis. Exercise and walnut oil have anti-inflammatory effects, but the effects of exercise and walnut oil on CES1 and ...
Shujuan Hu, Xuan Liu, Yiting Ding, Jun Chen, Xianwang Wang   +4 more
doaj   +2 more sources

NOS3 rs3918188C>A is associated with susceptibility to resistant hypertension while CES1 genetic variation was not associated with resistant hypertension among South Africans [PDF]

Frontiers in Genetics
IntroductionGenetic variation in genes coding for enzymes metabolising antihypertensive drugs, may affect the efficacy of angiotensin converting enzyme (ACE) inhibitors such as enalapril, potentially leading to resistant hypertension (RHTN).
Jonathan N. Katsukunya, Jonathan N. Katsukunya, Revina Naicker, Revina Naicker, Nyarai D. Soko, Nyarai D. Soko, Nyarai D. Soko, Dirk Blom, Dirk Blom, Phumla Sinxadi, Phumla Sinxadi, Emile R. Chimusa, Brian Rayner, Brian Rayner, Erika Jones, Erika Jones, Collet Dandara, Collet Dandara   +17 more
doaj   +2 more sources

Randomized evaluation of the loss‐of‐function carboxylesterase 1 (CES1) G143E variant on clopidogrel and ticagrelor pharmacodynamics [PDF]

Clinical and Translational Science
Antiplatelet therapy with a P2Y12 receptor inhibitor, in combination with aspirin, is standard of care for medical management of patients with coronary artery disease, and flexibility in prescribing options among these medications offers great potential ...
Joshua P. Lewis, Kathleen A. Ryan, Elizabeth A. Streeten, Hilary B. Whitlatch, Melanie Daue, Keith Tanner, James A. Perry, Jeffrey R. O'Connell, Alan R. Shuldiner, Braxton D. Mitchell   +9 more
doaj   +2 more sources

Carboxylesterase 1 family knockout alters drug disposition and lipid metabolism

Acta Pharmaceutica Sinica B, 2023
The mammalian carboxylesterase 1 (Ces1/CES1) family comprises several enzymes that hydrolyze many xenobiotic chemicals and endogenous lipids. To investigate the pharmacological and physiological roles of Ces1/CES1, we generated Ces1 cluster knockout ...
Changpei Gan, Jing Wang, Alejandra Martínez-Chávez, Michel Hillebrand, Niels de Vries, Joke Beukers, Els Wagenaar, Yaogeng Wang, Maria C. Lebre, Hilde Rosing, Sjoerd Klarenbeek, Rahmen Bin Ali, Colin Pritchard, Ivo Huijbers, Jos H. Beijnen, Alfred H. Schinkel   +15 more
doaj   +1 more source

Hepatic carboxylesterase 1 is induced by glucose and regulates postprandial glucose levels. [PDF]

PLoS ONE, 2014
Metabolic syndrome, characterized by obesity, hyperglycemia, dyslipidemia and hypertension, increases the risks for cardiovascular disease, diabetes and stroke.
Jiesi Xu, Liya Yin, Yang Xu, Yuanyuan Li, Munaf Zalzala, Gang Cheng, Yanqiao Zhang   +6 more
doaj   +1 more source