Results 11 to 20 of about 6,033 (189)

Interfering with lipid metabolism through targeting CES1 sensitizes hepatocellular carcinoma for chemotherapy

JCI Insight, 2023
Hepatocellular carcinoma (HCC) is the most common lethal form of liver cancer. Apart from surgical removal and transplantation, other treatments have not yet been well established for patients with HCC.
Gang Li, Xin Li, Iqbal Mahmud, Jazmin Ysaguirre, Baharan Fekry, Shuyue Wang, Bo Wei, Kristin L. Eckel-Mahan, Philip L. Lorenzi, Richard Lehner, Kai Sun   +10 more
doaj   +3 more sources

Association between CES1 rs2244613 and the pharmacokinetics and safety of dabigatran: Meta-analysis and quantitative trait loci analysis

Frontiers in Cardiovascular Medicine, 2022
ObjectiveTo date, the influence of the carboxylesterase 1 (CES1) rs2244613 genotype on the pharmacokinetics (PKs) and safety of dabigatran remains controversial.
Haobo Li, Haobo Li, Haobo Li, Haobo Li, Haobo Li, Zhu Zhang, Zhu Zhang, Zhu Zhang, Zhu Zhang, Haoyi Weng, Haoyi Weng, Haoyi Weng, Yuting Qiu, Pablo Zubiaur, Yu Zhang, Yu Zhang, Yu Zhang, Yu Zhang, Yu Zhang, Guohui Fan, Guohui Fan, Guohui Fan, Guohui Fan, Peiran Yang, Anna-Leena Vuorinen, Xianbo Zuo, Xianbo Zuo, Zhenguo Zhai, Zhenguo Zhai, Zhenguo Zhai, Zhenguo Zhai, Chen Wang, Chen Wang, Chen Wang, Chen Wang, Chen Wang   +35 more
doaj   +8 more sources

Associations between CES1 variants and dosing and adverse effects in children taking methylphenidate

Frontiers in Pediatrics, 2023
BackgroundMethylphenidate is the most prescribed stimulant to treat attention deficit-hyperactivity disorder (ADHD). Despite its widespread usage, a fair proportion of children are classified as non-responders to the medication.
Jacob T. Brown, Nancy Beery, Allise Taran, Tyler Stevens, Christine Henzler, Jonathan Badalamenti, Ron Regal, Catherine A. McCarty   +7 more
doaj   +3 more sources

The Impact of ABCB1 and CES1 Polymorphisms on Dabigatran Pharmacokinetics in Healthy Chinese Subjects

Pharmacogenomics and Personalized Medicine, 2021
Yue Liu,1,* Chenguang Yang,2,* Wenyuan Qi,1 Zuowei Pei,2 Wei Xue,1 Huolan Zhu,2 Min Dong,2 Ying Guo,2 Duanduan Cong,1 Fang Wang2 1Clinical Trial Center, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Science ...
Liu Y, Yang C, Qi W, Pei Z, Xue W, Zhu H, Dong M, Guo Y, Cong D, Wang F   +9 more
doaj   +4 more sources

CES1 and SLC6A2 Genetic Variants As Predictors of Response To Methylphenidate in Autism Spectrum Disorders

Pharmacogenomics and Personalized Medicine, 2022
Marta H Hernandez1,2 *, Valentin Bote3 *, Alexandre Serra-LLovich,1 Marc Cendros,1,4 Juliana Salazar,5 Conxita Mestres,2 Silvina Guijarro,3 Aida Alvarez,3 Cristina Lamborena,3 Iria Mendez,3 Bernardo Sanchez,3 Amaia Hervas,3 Maria J Arranz1,2 ...
Hernandez MH, Bote V, Serra-LLovich A, Cendros M, Salazar J, Mestres C, Guijarro S, Alvarez A, Lamborena C, Mendez I, Sanchez B, Hervas A, Arranz MJ   +12 more
doaj   +6 more sources

Unraveling the Link Between Azathioprine and Acute Pancreatitis: Integrating Network Toxicology, Machine Learning, and Mendelian Randomization

CPT: Pharmacometrics & Systems Pharmacology
Azathioprine (AZA), a widely used immunosuppressant, can induce acute pancreatitis (AP), yet the underlying molecular mechanisms remain unclear. This study employed an integrative multiomics strategy—combining network toxicology, machine learning ...
Zhijun Xie, Hang Lei, Pengcheng Zhang, Zhi Li, Wenfu Tang   +4 more
doaj   +2 more sources

Sacubitril is selectively activated by carboxylesterase 1 (CES1) in the liver and the activation is affected by CES1 genetic variation [PDF]

The FASEB Journal, 2016
Sacubitril was recently approved by the Food and Drug Administration for use in combination with valsartan for the treatment of patients with heart failure with reduced ejection fraction. As a prodrug, sacubitril must be metabolized (hydrolyzed) to its active metabolite sacubitrilat (LBQ657) to exert its intended therapeutic effects.
Jian, Shi, Xinwen, Wang, Jenny, Nguyen, Audrey H, Wu, Barry E, Bleske, Hao-Jie, Zhu   +5 more
  +9 more sources

Genetic variants of ABCB1 and CES1 genes on dabigatran metabolism in the Kazakh population [PDF]

Caspian Journal of Internal Medicine
Background: Allelic variants of genes encoding enzymes of the esterase system (CES1) and P-glycoprotein (ABCB1) can change the metabolism and pharmacokinetics of dabigatran.
Ayan Abdrakhmanov, Elena Zholdybayeva, Aizhana Shaimerdinova, Gulmira Kulmambetova, Svetlana Abildinova, Rustam Albayev, Gulnara Tuyakova, Elena Rib, Zhanasyl Suleimen, Zhanar Abdrakhmanova, Makhabbat Bekbossynova   +10 more
doaj   +3 more sources

Confounding Effect of Hepatic Carboxylesterase 1 (CES1) Variability on Clopidogrel Oxidation. [PDF]

Mol Pharm
Subash S, Singh DK, Khojasteh SC, Murray BP, Zientek MA, Jones RS, Kulkarni P, Smith BJ, Prasad B.   +8 more
europepmc   +2 more sources

Copy number variation in the CES1 gene and the risk of non-alcoholic fatty liver in a Chinese Han population

Scientific Reports, 2021
A recent genome-wide copy number variations (CNVs) scan identified a 16q12.2 deletion that included the carboxylesterase 1 (CES1) gene, which is important in the metabolism of fatty acids and cholesterol.
Bing bing Chen, Jian hui Yan, Jing Zheng, He wei Peng, Xiao ling Cai, Xin ting Pan, Hui quan Li, Qi zhu Hong, Xian-E Peng   +8 more
doaj   +1 more source