Results 41 to 50 of about 6,033 (189)
Correlation Between Trough Plasma Dabigatran Concentrations and Estimates of Glomerular Filtration Rate Based on Creatinine and Cystatin C [PDF]
, 2014 AIMS: Dabigatran is largely cleared by renal excretion. Renal function is thus a major determinant of trough dabigatran concentrations, which correlate with the risk of thromboembolic and haemorrhagic outcomes.
Berit P. Jensen +8 more
core +1 more source
Regulatory effects of genomic translocations at the human carboxylesterase-1 (CES1) gene locus [PDF]
Pharmacogenetics and Genomics, 2016 CES1 encodes carboxylesterase-1, an important drug-metabolizing enzyme with high expression in the liver. Previous studies have reported a genomic translocation of the 5' region from the poorly expressed pseudogene CES1P1, to CES1, yielding the structural variant CES1VAR.
Jonathan C, Sanford +6 more
openaire +2 more sources
Hydrolase activities of cynomolgus monkey liver microsomes and recombinant CES1, CES2, and AADAC
European Journal of Pharmaceutical Sciences, 2021 The cynomolgus monkey is a nonhuman primate that is often used for pharmacokinetic and toxicokinetic studies of new chemical entities. Species differences in drug metabolism are obstacles for the extrapolation of animal data to humans. This study aimed to characterize hydrolase activities for typical compounds by cynomolgus monkey liver microsomes and ...
Shiori, Honda +5 more
openaire +2 more sources
Age-Dependent Human Hepatic Carboxylesterase 1 (CES1) and Carboxylesterase 2 (CES2) Postnatal Ontogeny [PDF]
Drug Metabolism and Disposition, 2016 Human hepatic carboxylesterase 1 and 2 (CES1 and CES2) are important for the disposition of ester- and amide-bond-containing pharmaceuticals and environmental chemicals. CES1 and CES2 ontogeny has not been well characterized, causing difficulty in addressing concerns regarding juvenile sensitivity to adverse outcomes associated with exposure to certain
Ronald N Hines +2 more
openaire +2 more sources
Dabigatran etexilate activation is affected by the CES1 genetic polymorphism G143E (rs71647871) and gender [PDF]
Biochemical Pharmacology, 2016 The oral anticoagulant prodrug dabigatran etexilate (DABE) is sequentially metabolized by intestinal carboxylesterase 2 (CES2) and hepatic carboxylesterase 1 (CES1) to form its active metabolite dabigatran (DAB). A recent genome-wide association study reported that the CES1 single nucleotide polymorphisms (SNPs) rs2244613 and rs8192935 were associated ...
Jian, Shi +6 more
openaire +2 more sources
Interpolation of Ces{\`a}ro sequence and function spaces
, 2012 The interpolation property of Ces{\`a}ro sequence and function spaces is investigated. It is shown that $Ces_p(I)$ is an interpolation space between $Ces_{p_0}(I)$ and $Ces_{p_1}(I)$ for $1 < p_0 < p_1 \leq \infty$ and $1/p = (1 - \theta)/p_0 + \theta ...
Astashkin, Sergey V., Maligranda, Lech
core +2 more sources
Modal shift for New Zealand shippers for various policy scenarios [PDF]
, 2017 Increasing transport problems caused by high dependency on road transport, has brought us to investigate various policy scenarios to promote a greater use of rail and coastal transport for freight transport in New Zealand.
Kim, Hyun-Chan +2 more
core +1 more source
High-resolution physical map for chromosome 16q12.1-q13, the Blau syndrome locus [PDF]
, 2002 BACKGROUND: The Blau syndrome (MIM 186580), an autosomal dominant granulomatous disease, was previously mapped to chromosome 16p12-q21. However, inconsistent physical maps of the region and consequently an unknown order of microsatellite markers ...
Bonavita, Gina +4 more
core +4 more sources
Медицинский совет, 2020 Background: despite well-studied safety profile of dabigatran its interactions with genetic polymorphism parameters are poorly understood, especially in patients with moderate chronic kidney disease (CKD).
A. I. Skripka +12 more
doaj +1 more source
Pharmacokinetics and Pharmacogenetics of Dabigatran
Рациональная фармакотерапия в кардиологии, 2021 Dabigatran etexilate is a prodrug of dabigatran, a oral direct inhibitor of thrombin. Pharmacokinetics of dabigatran etexilate doesn’t have the disadvantages of vitamin K antagonists.
A. V. Savinova +4 more
doaj +1 more source