Results 61 to 70 of about 6,033 (189)
Surge in Expression of Carboxylesterase 1 During the Post-neonatal Stage Enables a Rapid Gain of the Capacity to Activate the Anti-influenza Prodrug Oseltamivir [PDF]
, 2017 Background. Oseltamivir, a widely used anti-influenza drug, is hydrolytically activated by carboxylesterase 1 (CES1). The expression of this carboxylesterase is developmentally regulated.
Davies, Brian E. +4 more
core
Local approach to order continuity in Ces\`aro function spaces
, 2017 The goal of this paper is to present a complete characterisation of points of order continuity in abstract Ces\`aro function spaces $CX$ for $X$ being a symmetric function space. Under some additional assumptions mentioned result takes the form $(CX)_a =
Kiwerski, Tomasz, Tomaszewski, Jakub
core +1 more source
Covalent fluorescent probes for 2‐arachidonoylglycerol metabolic pathways
British Journal of Pharmacology, EarlyView.Abstract Covalent fluorescent probes have emerged as versatile chemical tools to visualise active enzymes in complex biological systems. When tailored for specific applications, ranging from activity‐based protein profiling for drug development to high spatiotemporal resolution imaging of enzymatic activities, these probes provide unique insights into ...
Nick D. F. Puijmbroeck +1 more
wiley +1 more source
The impact ofCES1genotypes on the pharmacokinetics of methylphenidate in healthy Danish subjects [PDF]
British Journal of Clinical Pharmacology, 2017 AimsThis study investigated the influence ofCES1variations, including the single nucleotide polymorphism (SNP) rs71647871 (G143E) and variation in copy number, on the pharmacokinetics of a single oral dose of 10 mg methylphenidate.MethodsCES1genotype was obtained from 200 healthy Danish Caucasian volunteers.
Stage, Claus +8 more
openaire +3 more sources
Overreliance on Orthographic Similarity in L2‐Japanese Conceptual Processing by L1‐Chinese Learners
International Journal of Applied Linguistics, EarlyView.ABSTRACT Orthographic and phonological similarities between first (L1) and second (L2) languages can facilitate L2 processing. Particularly, L1‐Chinese learners of L2‐Japanese can benefit from the shared morphosyllabic Chinese characters (Japanese kanji/Chinese hanzi) because of their similar orthographies.
Xuehan Zhao, Kexin Xiong, Sachiko Kiyama
wiley +1 more source
Price Guarantees, Consumer Search, and Hassle Costs [PDF]
, 2013 The paper deals with the competitive effects of price guarantees in a spatial duopoly where consumers can search for lower prices but have to incur hassle costs if they want to claim a price guarantee.
Baake, Pio, Schwalbe, Ulrich
core +3 more sources
Japanese Women's Attitudes Toward Learning Languages Other Than English in the Era of Global English
International Journal of Applied Linguistics, EarlyView.ABSTRACT This study on female Japanese learners of the Korean language is situated in the centuries‐long anti‐Korean sentiments in Japan, the global popularity of the Korean Wave, particularly among women, and the essentialized image of socially marginalized young Japanese women who study English with romantic desires for Western men.
Yoko Kobayashi
wiley +1 more source
Атеротромбоз, 2018 Oral anticoagulants are widely used to prevent thromboembolic events in patients following total knee arthroplasty [1]. The genetic characteristics of patients affect the efficacy and safety of anticoagulants [2].
D. A. Sychev +8 more
doaj +1 more source
A dysregulation in CES1, APOE and other lipid metabolism-related genes is associated to cardiovascular risk factors linked to obesity [PDF]
, 2010 OBJECTIVE: The aim of the present study was to investigate the relationship between the differential expression of genes related to lipid metabolism in subcutaneous adipose tissue and metabolic syndrome features in lean and obese subjects with ...
Gonzalez-Muniesa, P. (Pedro) +3 more
core
Veterinary Dermatology, EarlyView.ABSTRACT Background Canine atopic dermatitis (cAD) is a multifactorial, inherited skin disease, estimated to affect ≤ 15% of dogs. Studies of skin messenger mRNA in cAD currently use invasive methods, including blood sampling and biopsy collection, whilst advances in human atopic dermatitis study methodology have demonstrated reliable use of minimally ...
Xavier Langon +5 more
wiley +1 more source