Results 71 to 80 of about 6,033 (189)

ABCA12 Frameshift Deletion in Domestic Cats With Ichthyosis Fetalis

Veterinary Dermatology, EarlyView.
ABSTRACT Background Ichthyosis fetalis (IF), also known as harlequin ichthyosis, is a rare and often fatal autosomal recessive congenital skin disorder. It is characterized by thickened, hard skin plaques and deep skin fissures that limit mobility and cause malformations of the eyes, lips and ears.
Jeanna M. Blake, Melissa P. Swan, Kari J. Ekenstedt   +2 more
wiley   +1 more source

Impact of carboxylesterase 1 genetic polymorphism on trandolapril activation in human liver and the pharmacokinetics and pharmacodynamics in healthy volunteers

Clinical and Translational Science, 2021
Trandolapril, an angiotensin‐converting enzyme inhibitor prodrug, needs to be activated by carboxylesterase 1 (CES1) in the liver to exert its intended therapeutic effect.
Xinwen Wang, Lucy Her, Jingcheng Xiao, Jian Shi, Audrey H. Wu, Barry E. Bleske, Hao‐Jie Zhu   +6 more
doaj   +1 more source

Activation of Tenofovir Alafenamide and Sofosbuvir in the Human Lung and Its Implications in the Development of Nucleoside/Nucleotide Prodrugs for Treating SARS-CoV-2 Pulmonary Infection

Pharmaceutics, 2021
ProTide technology is a powerful tool for the design of nucleoside/nucleotide analog prodrugs. ProTide prodrug design improves cell permeability and enhances intracellular activation.
Jiapeng Li, Shuhan Liu, Jian Shi, Hao-Jie Zhu   +3 more
doaj   +1 more source

The Pharmacokinetics of Enalapril in Relation toCES1Genotype in Healthy Danish Volunteers [PDF]

Basic & Clinical Pharmacology & Toxicology, 2017
AbstractThis study investigated the influence of variations in the carboxylesterase 1 gene (CES1)on the pharmacokinetics of enalapril. Forty‐three healthy, Danish, Caucasian volunteers representing different pre‐defined genotypes each received 10 mg of enalapril.
Stage, Claus, Jürgens, Gesche, Guski, Louise Schow, Thomsen, Ragnar, Bjerre, Ditte, Ferrero-Miliani, Laura, Lyauk, Yassine Kamal, Berg Rasmussen, Henrik, Dalhoff, Kim   +8 more
openaire   +3 more sources

Tolerability and Feasibility of Minimally Invasive Canine Skin Sampling: Excellent Tolerability Meets Transcriptomic Challenges

Veterinary Dermatology, EarlyView.
ABSTRACT Background Advances in transcriptomics have driven the demand for minimally invasive, reproducible and high‐yield skin sampling methods, particularly for studying inflammatory skin diseases in companion animals. Hypothesis/Objectives We tested tolerability, feasibility and RNA quantity and quality of three minimally invasive skin sampling ...
Ina Herrmann, Lisa B. Mamo, Allison N. Dickey   +2 more
wiley   +1 more source

Melatonin inhibits lipid accumulation to repress prostate cancer progression by mediating the epigenetic modification of CES1

Clinical and Translational Medicine, 2021
Background Androgen deprivation therapy (ADT) is the main clinical treatment for patients with advanced prostate cancer (PCa). However, PCa eventually progresses to castration‐resistant prostate cancer (CRPC), largely because of androgen receptor ...
Lijie Zhou, Cai Zhang, Xiong Yang, Lilong Liu, Junyi Hu, Yaxin Hou, Hong Tao, Haruhiko Sugimura, Zhaohui Chen, Liang Wang, Ke Chen   +10 more
doaj   +1 more source

Bacteriophage and Fusidic Acid Have Synergistic Effect Against Meticillin‐Resistant Staphylococcus pseudintermedius in Ex Vivo Canine Dermis Model

Veterinary Dermatology, Volume 37, Issue 2, Page 200-210, April 2026.
Background: Antimicrobial stewardship has become vital given the progressive emergence of multidrug‐resistant bacteria, and novel approaches to the treatment of bacterial infections are needed. Recently, reported synergistic effects of antibacterial drugs and bacteriophage therapy have revealed promising applications for the management of meticillin ...
Sarah Ehling, Elisa Peh, Hilke Oltmanns, Jessica Meissner, Sophie Kittler, Christina Puff, Jutta Verspohl, Mathias Müsken, Madeleine Plötz, Andrea Vanessa Volk   +9 more
wiley   +1 more source

Effects of deletion mutations in the yeast Ces1 protein on cell growth and morphology and on high copy suppression of mutations in mRNA capping enzyme and translation initiation factor 4A [PDF]

, 2017
The homologous Saccharomyces cerevisiae genes CES1 and CES4 act as high copy suppressors of temperature-sensitive mutations of Ceg1p, the yeast mRNA capping enzyme. Neither CES1 nor CES4 is essential for cell growth. We find that a double deletion mutant
Linder, Patrick, Schwer, Beate, Shuman, Stewart   +2 more
core  

Comprehensive maximum likelihood estimation of diffusion compartment models towards reliable mapping of brain microstructure [PDF]

, 2016
open4siDiffusion MRI is a key in-vivo non invasive imaging capability that can probe the microstructure of the brain. However,its limited resolution requires complex voxelwise generative models of the diffusion.
B Scherrer, B Scherrer, D Marquardt, K Svanberg, Panagiotaki, V Essen, Zhang   +6 more
core   +3 more sources

Increased serum carboxylesterase-1 levels are associated with metabolic dysfunction associated steatotic liver disease and metabolic syndrome in children with obesity

Italian Journal of Pediatrics
Background Carboxylesterase 1(CES1) is expressed mainly in the liver and adipose tissue and is highly hypothesized to play an essential role in metabolism.
Huanyu Wang, Shimin Wu, Ying Weng, Xi Yang, Ling Hou, Yan Liang, Wei Wu, Yanqin Ying, Feng Ye, Xiaoping Luo   +9 more
doaj   +1 more source