Results 31 to 40 of about 49,554 (304)
The biological role of the CXCL12/CXCR4 axis in esophageal squamous cell carcinoma
Cancer Biology & Medicine, 2021 Esophageal cancer is the eighth most common malignant tumor and the sixth leading cause of cancer-related death worldwide. Esophageal squamous cell carcinoma (ESCC) is the main histological type of esophageal cancer, and accounts for 90% of all cancer ...
Xianxian Wu +4 more
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A guide to chemokines and their receptors [PDF]
, 2018 The chemokines (or chemotactic cytokines) are a large family of small, secreted proteins that signal through cell surface G‐protein coupled heptahelical chemokine receptors.
Braun A +11 more
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CXCL12-PLGA/Pluronic Nanoparticle Internalization Abrogates CXCR4-Mediated Cell Migration
Nanomaterials, 2020 Chemokine-induced chemotaxis mediates physiological and pathological immune cell trafficking, as well as several processes involving cell migration. Among them, the role of CXCL12/CXCR4 signaling in cancer and metastasis is well known, and CXCR4 has been
Anissa Pisani +8 more
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CXCL12/CXCR4 axis: an emerging neuromodulator in pathological pain [PDF]
, 2016 The roles of chemokine C-X-C motif ligand 12 (CXCL12) and its receptor chemokine C-X-C motif receptor 4 (CXCR4) reveal this chemokine axis as an emerging neuromodulator in the nervous system. In the peripheral and central nervous systems, both CXCL12 and
Cheung, CW +4 more
core +1 more source
Effects of the chemokine CXCL12 on dendritic spine dynamics
Dendritic spines are structural substrates for learning and memory and their pruning is associated with cognitive decline in conditions like Alzheimer's Disease and HIV-associated neurocognitive disorders (HAND). Our past studies in a rodent model of HAND (HIV-transgenic rat, HIV-Tg) revealed that dendritic spine loss and related cognitive deficits can
Chun-Ta Ho +2 more
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MIF and CXCL12 in cardiovascular diseases: functional differences and similarities
Frontiers in Immunology, 2015 Coronary artery disease (CAD) as part of the cardiovascular diseases is a pathology caused by atherosclerosis, a chronic inflammatory disease of the vessel wall characterized by a massive invasion of lipids and inflammatory cells into the inner vessel ...
Emiel eVan Der Vorst +2 more
doaj +1 more source
Questions about Chemokine and Chemokine Receptor Antagonism in Renal Inflammation [PDF]
, 2010 Chemokines remain attractive therapeutic targets for modulating inflammatory diseases in all areas of medicine including acute and chronic kidney disease.
Anders, Hans-Joachim +2 more
core +1 more source
Peptide-binding induced inhibition of chemokine CXCL12
RSC Advances, 2017 A designed peptide (W4) has a significant inhibitory effect on the CXCL12/CXCR4 axis by targeting CXCL12 with high binding affinity.
Hongyang Duan +13 more
openaire +2 more sources
The chemokine CXCL12 regulates monocyte-macrophage differentiation and RUNX3 expression [PDF]
Blood, 2011 Abstract Monocytes are versatile cells that can express different functional programs in response to microenvironmental signals. We show that primary blood monocytes secrete the CXCL12 chemokine, and express the CXCR4 and CXCR7 receptors, leading to an autocrine/paracrine loop that contribute to shape monocyte differentiation to a ...
Sánchez-Martín, Lorena +5 more
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The diagnostic significance of the chemokine CXCL12 in Alzheimer's disease [PDF]
Alzheimer's & Dementia, 2021 AbstractBackgroundA complex relationship between the stromal cell‐derived factor 1 (CXCL12) and dementia, including mild cognitive impairment (MCI) and Alzheimer's disease (AD) has been described in the literature. The chemokine CXCL12 regulates many functions of bone marrow‐derived stem cells and has been implicated in neurogenesis as well as with the
Barbara Mroczko +5 more
openaire +1 more source