Cholesterol 25-hydroxylase suppresses avian reovirus replication by its enzymatic product 25-hydroxycholesterol [PDF]
Frontiers in Microbiology, 2023 Avian reovirus (ARV) causing viral arthritis/tenosynovitis and viral enteritis in domestic fowl has significantly threatened on the poultry industry worldwide. ARV is a non-enveloped fusogenic virus that belongs to the Reoviridae family.
Yuyang Wang +9 more
doaj +2 more sources
Research progress on the mechanism of cholesterol-25-hydroxylase in intestinal immunity [PDF]
Frontiers in Immunology, 2023 Inflammatory bowel disease (IBD), a general term encompassing Crohn’s disease (CD) and ulcerative colitis (UC), and other conditions, is a chronic and relapsing autoimmune disease that can occur in any part of the digestive tract.
Guoqiang Zhong +4 more
doaj +2 more sources
Hepatic Reduction in Cholesterol 25-Hydroxylase Aggravates Diet-induced SteatosisSummary [PDF]
Cellular and Molecular Gastroenterology and Hepatology, 2022 Background & Aims: Cholesterol 25-hydroxylase (Ch25h), converting cholesterol to 25-hydroxycholesterol (25-HC), is critical in modulating cellular lipid metabolism and anti-inflammatory and antiviral activities.
Zeyu Dong +10 more
doaj +2 more sources
Dual-Role of Cholesterol‐25‐Hydroxylase in Regulating Hepatitis B Virus Infection and Replication [PDF]
mBio, 2022 Hepatitis B virus (HBV)‐related diseases are among the major diseases that affect millions of people worldwide. These diseases are difficult to eradicate and thus pose a serious global health challenge.
Qi Wei +10 more
doaj +2 more sources
Cholesterol 25-Hydroxylase Suppresses Swine Acute Diarrhea Syndrome Coronavirus Infection by Blocking Spike Protein-Mediated Membrane Fusion [PDF]
Viruses, 2023 Swine acute diarrhea syndrome coronavirus (SADS-CoV) is an emerging porcine intestinal coronavirus that can cause acute diarrhea, vomiting, rapid weight loss, and high mortality in newborn piglets.
Dakai Liu +13 more
doaj +2 more sources
Thrombin increases the expression of cholesterol 25-hydroxylase in rat astrocytes after spinal cord injury [PDF]
Neural Regeneration Research, 2023 Astrocytes are important cellular centers of cholesterol synthesis and metabolism that help maintain normal physiological function at the organism level. Spinal cord injury results in aberrant cholesterol metabolism by astrocytes and excessive production
Chen Chen +9 more
doaj +2 more sources
Cholesterol 25-hydroxylase inhibits Newcastle disease virus replication by enzyme activity-dependent and direct interaction with nucleocapsid protein [PDF]
Journal of VirologyNewcastle disease virus (NDV) is a significant enveloped virus within the Paramyxoviridae family, posing a major threat to the global poultry industry.
Guangmei Zhu +15 more
doaj +2 more sources
Heightened cholesterol 25-hydroxylase expression in aged lung during Streptococcus pneumoniae [PDF]
Frontiers in AgingIntroductionAlveolar macrophages (AM) are critical effectors of the immune response and are essential for host responses to Streptococcus pneumoniae. Changes in lipid metabolism in AM can alter cellular function and biology.
David G. Thomas +5 more
doaj +2 more sources
Interferon-induced miR-7705 modulates the anti-virus activity of cholesterol 25-hydroxylase [PDF]
Journal of VirologyCholesterol 25-hydroxylase (CH25H), an interferon-stimulated gene (ISG), has been implicated in broad-spectrum antiviral immunity. Here, we identify CH25H as a potent suppressor of hepatitis B virus (HBV) replication that significantly outperforms IFN-α ...
Le Wang +11 more
doaj +2 more sources
Role of Cholesterol 25-Hydroxylase (Ch25h) in Mediating Innate Immune Responses to Streptococcus pneumoniae Infection [PDF]
Cells, 2023 Alveolar macrophages (AM) are long-lived tissue-resident innate immune cells of the airways. AM are key effectors of recognition, initiation, and resolution of the host defense against microbes and play an essential role in mediating host responses to ...
Soo Jung Cho +4 more
doaj +2 more sources