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Claudins in lung diseases [PDF]
Respiratory Research, 2011 Tight junctions are the most apically localized part of the epithelial junctional complex. They regulate the permeability and polarity of cell layers and create compartments in cell membranes. Claudins are structural molecules of tight junctions.
Soini Ylermi
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Expression patterns of claudins in cancer
Heliyon, 2023 Claudins are four-transmembrane proteins, which were found in tight junctions. They maintain cell barriers and regulate cell differentiation and proliferation. They are involved in maintaining cellular polarity and normal functions.
Hui Li
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Molecular Characterization of Barrier Properties in Follicle-Associated Epithelium of Porcine Peyer's Patches Reveals Major Sealing Function of Claudin-4 [PDF]
Frontiers in Physiology, 2017 The pig represents a preferred model for the analysis of intestinal immunology. However, the barrier of the follicle-associated epithelium (FAE) covering porcine Peyer's patches (PP) has not yet been characterized in detail.
Judith Radloff +3 more
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Tissue Barriers, 2013 Intestines are organs that not only digest food and absorb nutrients, but also provide a defense barrier against pathogens and noxious agents ingested. Tight junctions (TJs) are the most apical component of the junctional complex, providing one form of ...
Lei Ding, Qun Lu
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Claudins: Beyond Tight Junctions in Human IBD and Murine Models
Frontiers in Pharmacology, 2021 Claudins are transmembrane proteins constituting one of three tight junction protein families. In patients with inflammatory bowel disease (IBD), disease activity–dependent changes in expression of certain claudins have been noted, thus making certain ...
Brankica Mijandrusić-Sincić
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Intestinal Barrier, Claudins and Mycotoxins
Toxins, 2021 The intestinal barrier is the main barrier against all of the substances that enter the body. Proper functioning of this barrier guarantees maintained balance in the organism. Mycotoxins are toxic, secondary fungi metabolites, that have a negative impact
Marta Justyna Kozieł +2 more
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On the Interaction of Clostridium perfringens Enterotoxin with Claudins
Toxins, 2010 Clostridium perfringens causes one of the most common foodborne illnesses, which is largely mediated by the Clostridium perfringens enterotoxin (CPE). The toxin consists of two functional domains.
Jonas Protze, Gerd Krause, Jörg Piontek
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Deciphering the role of claudins in lung cancer [PDF]
Frontiers in OncologyLung cancer remains a major global health challenge, characterized by aggressive malignancy and poor prognostic outcomes. This review article focuses on the pivotal role of claudins, a family of tight junction proteins, in the pathophysiology of lung ...
Tarek Ziad Arabi +5 more
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Claudins in genitourinary tract neoplasms: mechanisms, prognosis, and therapeutic prospects
Frontiers in Cell and Developmental Biology, 2023 Genitourinary (GU) cancers are among the most prevalent neoplasms in the world, with bladder cancers constituting 3% of global cancer diagnoses. However, several pathogenetic mechanisms remain controversial and unclear.
Tarek Ziad Arabi +4 more
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Context-Dependent Roles of Claudins in Tumorigenesis
Frontiers in Oncology, 2021 The barrier and fence functions of the claudin protein family are fundamental to tissue integrity and human health. Increasing evidence has linked claudins to signal transduction and tumorigenesis. The expression of claudins is frequently dysregulated in
Jian Li
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