Results 21 to 30 of about 20,415 (303)
Developmental expression of claudins in the mammary gland [PDF]
, 2017 Claudins are a large family of membrane proteins whose classic function is to regulate the permeability of tight junctions in epithelia. They are tetraspanins, with four alpha-helices crossing the membrane, two extracellular loops, a short cytoplasmic N ...
Baumgartner, Heidi K. +8 more
core +1 more source
Frontiers in Genetics, 2023 The claudin multigene family is associated with various aberrant physiological and cellular signaling pathways. However, the association of claudins with survival prognosis, signaling pathways, and diagnostic efficacy in colon cancer remains poorly ...
Rana A. Alghamdi +2 more
doaj +1 more source
Tilivalline- and Tilimycin-Independent Effects of Klebsiella oxytoca on Tight Junction-Mediated Intestinal Barrier Impairment [PDF]
, 2019 Klebsiella oxytoca causes antibiotic-associated hemorrhagic colitis and diarrhea. This was attributed largely to its secreted cytotoxins tilivalline and tilimycin, inductors of epithelial apoptosis.
Bücker, Roland +8 more
core +1 more source
Toxins, 2010 Clostridium perfringens enterotoxin (CPE), a major cause of food poisoning, forms physical pores in the plasma membrane of intestinal epithelial cells. The ability of CPE to recognize the epithelium is due to the C-terminal binding domain, which binds to
Leslie A. Mitchell, Michael Koval
doaj +1 more source
Current Issues in Molecular Biology, 2023 Metastatic colon cancer remains incurable despite improvements in survival outcomes. New therapies based on the discovery of colon cancer genomic subsets could improve outcomes.
Ioannis A. Voutsadakis
doaj +1 more source
The Journal of Cell Biology, 1999 Tight junctions (TJs) in endothelial cells are thought to determine vascular permeability. Recently, claudin-1 to -15 were identified as major components of TJ strands. Among these, claudin-5 (also called transmembrane protein deleted in velo-cardio-facial syndrome [TMVCF]) was expressed ubiquitously, even in organs lacking epithelial tissues ...
Kazumasa Morita +3 more
openaire +1 more source
Use of Modified Clostridium perfringens Enterotoxin Fragments for Claudin Targeting in Liver and Skin Cells [PDF]
, 2019 Claudins regulate paracellular permeability in different tissues. The claudin-binding domain of Clostridium perfringens enterotoxin (cCPE) is a known modulator of a claudin subset. However, it does not efficiently bind to claudin-1 (Cldn1).
Beier, Laura-Sophie +12 more
core +2 more sources
Frontiers in Immunology, 2019 Claudins are a multigene transmembrane protein family comprising at least 27 members. In gastrointestinal tract, claudins are mainly located in the intestinal epithelia; many types of claudins form a network of strands in tight junction plaques within ...
Liguo Zhu +5 more
doaj +1 more source
Evolution of the vertebrate claudin gene family: insights from a basal vertebrate, the sea lamprey [PDF]
, 2016 Claudins are major constituents of tight junctions, contributing both to their intercellular sealing and selective permeability properties. While claudins and claudin-like molecules are present in some invertebrates, the association of claudins with ...
Bronner, Marianne E. +5 more
core +2 more sources
Frontiers in Oncology, 2020 High-grade serous ovarian carcinoma (HGSOC) usually spreads directly into the peritoneal cavity following a transcoelomic dissemination route, although distant hematogenous metastasis exist and have been reported.
Chiara Romani +27 more
doaj +1 more source