Results 41 to 50 of about 20,415 (303)

Mouse Models of Human Claudin-Associated Disorders: Benefits and Limitations [PDF]

, 2019
In higher organisms, epithelia separate compartments in order to guarantee their proper function. Such structures are able to seal but also to allow substances to pass.
Fernández-Rodríguez, Cármen, Martínez-Cruz, Luis Alfonso, Müller, Dominik, Seker, Murat   +3 more
core   +1 more source

Optimal DL-Methionyl-DL-Methionine Supplementation Improved Intestinal Physical Barrier Function by Changing Antioxidant Capacity, Apoptosis and Tight Junction Proteins in the Intestine of Juvenile Grass Carp (Ctenopharyngodon idella)

Antioxidants, 2022
The present study was a part of a larger research project that aimed to investigate the effects of Met-Met supplementation on fish growth and intestinal health. This study mainly focused on the relationship between dietary Met-Met and intestinal physical
Pei Wu, Yuening Su, Lin Feng, Weidan Jiang, Shengyao Kuang, Ling Tang, Jun Jiang, Yang Liu, Xiaoqiu Zhou   +8 more
doaj   +1 more source

Artificial rearing influences the morphology, permeability and redox state of the gastrointestinal tract of low and normal birth weight piglets [PDF]

, 2017
Background: In this study the physiological implications of artificial rearing were investigated. Low (LBW) and normal birth weight (NBW) piglets were compared as they might react differently to stressors caused by artificial rearing.
Casteleyn, Christophe, De Smet, Stefaan, Degroote, Jeroen, Fransen, Erik, Michiels, Joris, Prims, Sara, Van Cruchten, Steven, Van Ginneken, Chris, Vergauwen, Hans, Wang, Wei   +9 more
core   +1 more source

Antibody-mediated targeting of Claudins in cancer

Frontiers in Oncology
Tight junctions (TJs) are large intercellular adhesion complexes that maintain cell polarity in normal epithelia and endothelia. Claudins are critical components of TJs, forming homo- and heteromeric interaction between adjacent cells, which have emerged
Benjamin Vonniessen, Benjamin Vonniessen, Sébastien Tabariès, Sébastien Tabariès, Peter M. Siegel, Peter M. Siegel, Peter M. Siegel, Peter M. Siegel, Peter M. Siegel   +8 more
doaj   +1 more source

Claudin expression during early postnatal development of the murine cochlea [PDF]

, 2018
Citation: Kudo, T., Wangemann, P., & Marcus, D. C. (2018). Claudin expression during early postnatal development of the murine cochlea. BMC Physiology, 18(1), 1.
Kudo, Takayuki, Marcus, Daniel C., Wangemann, Philine   +2 more
core   +3 more sources

Blood-Brain Barrier Protein Claudin-5 Expressed in Paired Xenopus laevis Oocytes Mediates Cell-Cell Interaction

Frontiers in Physiology, 2020
Claudin-5 determines the sealing properties of blood-brain barrier tight junctions and its function is impaired in neurodegenerative and neuroinflammatory disorders.
Nora Brunner, Laura Stein, Valeria Cornelius, Ria Knittel, Petra Fallier-Becker, Salah Amasheh   +5 more
doaj   +1 more source

miR-195-5p Regulates Tight Junctions Expression via Claudin-2 Downregulation in Ulcerative Colitis

Biomedicines, 2022
Inflammatory bowel disease (IBD) is characterized by chronic intestinal inflammation associated with an increased intestinal permeability. Several studies have shown that microRNAs (miRNAs) are involved in the IBD pathogenesis.
Viviana Scalavino, Emanuele Piccinno, Antonio Lacalamita, Angela Tafaro, Raffaele Armentano, Gianluigi Giannelli, Grazia Serino   +6 more
doaj   +1 more source

The kidney tight junction [PDF]

, 2014
The tight junction is an important subcellular organelle which plays a vital role in epithelial barrier function. Claudin, as the integral membrane component of tight junctions, creates a paracellular transport pathway for various ions to be reabsorbed ...
Hou, Jianghui
core   +2 more sources

Claudin and pancreatic cancer

Frontiers in Oncology, 2023
Due to the lack of timely and accurate screening modalities and treatments, most pancreatic cancer (PCa) patients undergo fatal PCa progression within a short period since diagnosis. The claudin(CLDN) family is expressed specifically as tight junction structure in a variety of tumors, including PCa, and affects tumor progression by changing the cell ...
Chen Wang, Chen Wang, Na Wu, Beibei Pei, Xiaoyan Ma, Wenhui Yang   +5 more
openaire   +3 more sources

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source