Results 1 to 10 of about 5,097 (156)

Complement C1r serine protease contributes to kidney fibrosis. [PDF]

Am J Physiol Renal Physiol, 2019
We have previously reported that complement activation precedes the development of kidney fibrosis; however, little is known about the cellular mechanisms involved in this transition. We hypothesized that increased expression of C1 complex protease C1r, the initiator of complement activation, contributes to tubulointerstitial fibrosis and tested this ...
Xavier S, Sahu RK, Bontha SV, Mass V, Taylor RP, Megyesi J, Thielens NM, Portilla D.   +7 more
europepmc   +4 more sources

C1R Mutations Trigger Constitutive Complement 1 Activation in Periodontal Ehlers-Danlos Syndrome [PDF]

Frontiers in Immunology, 2019
Heterozygous missense or in-frame insertion/deletion mutations in complement 1 subunits C1r and C1s cause periodontal Ehlers-Danlos Syndrome (pEDS), a specific EDS subtype characterized by early severe periodontal destruction and connective tissue ...
Rebekka Gröbner, Ines Kapferer-Seebacher, Albert Amberger, Rita Redolfi, Fabien Dalonneau, Erik Björck, Erik Björck, Di Milnes, Isabelle Bally, Veronique Rossi, Nicole Thielens, Heribert Stoiber, Christine Gaboriaud, Johannes Zschocke   +13 more
doaj   +5 more sources

Plasma Proteomic Signatures of Pediatric Sepsis Reveal Persistent Inflammation and Phase-Specific Biomarkers. [PDF]

FASEB Bioadv
We enrolled a pediatric sepsis cohort at acute and recovery phases for plasma proteomics analysis. Abundantly expressed proteins in sepsis were identified and subjected to machine learning. In addition, the data was compared to adult sepsis and sterile inflammation.
Alhamdan F, Sin YC, Malm E, Van Pelt H, Kim S, Higgins L, Chen Y, Yuki K.   +7 more
europepmc   +2 more sources

BBK32 attenuates antibody-dependent complement-mediated killing of infectious Borreliella burgdorferi isolates. [PDF]

PLoS Pathogens
Borreliella burgdorferi, the causative agent of Lyme disease, has evolved unique complement evasion proteins that promote its ability to establish and maintain infection in mammalian hosts. Among these is B.
Alexandra D Powell-Pierce, Charles E Booth, Payton G Smith, Brittany L Shapiro, Shannon S Allen, Brandon L Garcia, Jon T Skare   +6 more
doaj   +2 more sources

The insider's perspective: The intracellular complosome and immune cell dynamics in cancer. [PDF]

Clin Transl Med
Intracellular complement (complosome) shapes the tumour immune microenvironment. Complosome's role in cancer is underrecognised yet central to tumour immunity. C3/C5‐driven complosome signals rewire T‐cell activation, fate and metabolism. Complosome activity can promote pro‐tumour immune cell function.
Bennion A, Lysaght J, Lynam-Lennon N.
europepmc   +2 more sources

Blocking activation of the C1r zymogen defines a novel mode of complement inhibition. [PDF]

J Biol Chem
Many hematophagous organisms secrete inhibitors of the coagulation and complement systems as constituents of their salivary fluid. Whereas previous studies on salivary gland extracts from the sandfly Lutzomyia longipalpis identified SALO (salivary anticomplement from L.
Duan H, Wu W, Li P, Bouyain S, Garcia BL, Geisbrecht BV.   +5 more
europepmc   +3 more sources

Proteomics identifies complement protein signatures in patients with primary biliary cholangitis [PDF]

European Journal of Medical Research
Primary biliary cholangitis (PBC) is a chronic autoimmune liver disease lacking reliable biomarkers for diagnosis or prognosis. To identify plasma complement biomarkers that improve diagnosis and prognosis of PBC.
Xiaolin Ma, Hang Dong, Junming Han, Ming Han, Teng Zhang, Meng Zhou, Xiude Fan, Luna Liu, Zhen Wang   +8 more
doaj   +2 more sources

Spatial heterogeneity in microglia-complement crosstalk: Implications for synaptic pruning in Alzheimer's disease. [PDF]

Alzheimers Dement
Abstract Alzheimer's disease (AD) is a neurodegenerative disorder characterized by synaptic loss, as a key pathological feature in its early stages. Recent studies have highlighted the central role of microglia–complement interactions in synaptic pruning.
Ye Q, Gao W, Feng J, Li X, Li J, Yang F, Li L, Zi M, Wu X, Gao H, Li H.   +10 more
europepmc   +2 more sources

Complement pathway dysregulation and astrocyte alterations in Down syndrome: evidence from postmortem brain tissue and iPSC-derived astrocytes [PDF]

Acta Neuropathologica Communications
Background Down syndrome (DS), or trisomy 21 (T21), resulting from an extra copy of chromosome 21, occurs in 1 in 700–1,000 live births. Neuroinflammation is increasingly recognized as a critical contributor to DS neuropathology, although its underlying ...
André Luíz Teles e Silva, Pedro Henrique Prado de Oliveira, Bruno Yukio Yokota-Moreno, Jéssica da Silva Fausto, Jonatan Peña Avila, Helder I. Nakaya, Andréa Laurato Sertié, Bruna Lancia Zampieri   +7 more
doaj   +2 more sources

A novel human complement-related protein, C1r-like protease (C1r-LP), specifically cleaves pro-C1s [PDF]

Biochemical Journal, 2005
The availability of the human genome sequence allowed us to identify a human complement-related, C1r-like protease gene (c1r-LP) located 2 kb centromeric of the C1r gene (c1r). Compared with c1r, c1r-LP carries a large deletion corresponding to exons 4–8 of c1r.
Christina, Ligoudistianou, Yuanyuan, Xu, Gerard, Garnier, Antonella, Circolo, John E, Volanakis   +4 more
  +6 more sources