Frontiers in Immunology, 2022 Pathogens that traffic in the blood of their hosts must employ mechanisms to evade the host innate immune system, including the complement cascade. The Lyme disease spirochete, Borreliella burgdorferi, has evolved numerous outer membrane lipoproteins ...
Charles E. Booth +3 more
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Corrigendum: C1R Mutations Trigger Constitutive Complement 1 Activation in Periodontal Ehlers-Danlos Syndrome [PDF]
Frontiers in Immunology, 2019 Rebekka Gröbner +13 more
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Periodontal Ehlers-Danlos Syndrome Is Caused by Mutations in C1R and C1S , which Encode Subcomponents C1r and C1s of Complement [PDF]
The American Journal of Human Genetics, 2016 Periodontal Ehlers-Danlos syndrome (pEDS) is an autosomal-dominant disorder characterized by early-onset periodontitis leading to premature loss of teeth, joint hypermobility, and mild skin findings. A locus was mapped to an approximately 5.8 Mb region at 12p13.1 but no candidate gene was identified.
Kapferer-Seebacher, Ines +54 more
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Molecules, 2020 The initiating protease of the complement classical pathway, C1r, represents an upstream and pathway-specific intervention point for complement-related autoimmune and inflammatory diseases.
Blake R. Rushing +4 more
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Borrelia burgdorferi BBK32 Inhibits the Classical Pathway by Blocking Activation of the C1 Complement Complex. [PDF]
PLoS Pathogens, 2016 Pathogens that traffic in blood, lymphatics, or interstitial fluids must adopt strategies to evade innate immune defenses, notably the complement system.
Brandon L Garcia +4 more
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The role of complement in the clinical course of hepatocellular carcinoma
Immunity, Inflammation and Disease, 2022 Background The complement system, an innate immune system, may either play an antitumor role, or promote tumorigenesis and cancer progression in different kinds of cancer. The function of complement in hepatocellular carcinoma (HCC) is unclear.
Xinye Qian +4 more
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Degradation of collagen I by activated C1s in periodontal Ehlers-Danlos Syndrome
Frontiers in Immunology, 2023 Periodontal Ehlers-Danlos syndrome (pEDS) is an autosomal dominant disorder characterized by early-onset periodontitis leading to premature loss of teeth, lack of attached gingiva and thin and fragile gums leading to gingival recession. Connective tissue
Albert Amberger +8 more
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Complement components C1q, C1r/C1s, and C1inh in rheumatoid arthritis [PDF]
Arthritis & Rheumatism, 1995 AbstractObjective. To analyze the synovial site and the cell types expressing C1q, C1r/C1s, and C1–esterase inhibitor (C1INH) and to characterize newly synthesized C1q in patients with rheumatoid arthritis (RA).Methods. Tissue and primary cell cultures of synovium from RA patients were analyzed for C1q, C1r/C1s, and C1INH by Northern blotting, in situ ...
Susanne Breitner +3 more
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Novel scabies mite serpins inhibit the three pathways of the human complement system. [PDF]
PLoS ONE, 2012 Scabies is a parasitic infestation of the skin by the mite Sarcoptes scabiei that causes significant morbidity worldwide, in particular within socially disadvantaged populations. In order to identify mechanisms that enable the scabies mite to evade human
Angela Mika +11 more
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Molecular Determinants of the Substrate Specificity of the Complement-initiating Protease, C1r [PDF]
Journal of Biological Chemistry, 2013 The serine protease, C1r, initiates activation of the classical pathway of complement, which is a crucial innate defense mechanism against pathogens and altered-self cells. C1r both autoactivates and subsequently cleaves and activates C1s. Because complement is implicated in many inflammatory diseases, an understanding of the interaction between C1r ...
Lakshmi C, Wijeyewickrema +9 more
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