Complement C1s deficiency in a male Caucasian patient with systemic lupus erythematosus: a case report [PDF]
Frontiers in Immunology, 2023 Deficiencies of the early complement components of the classical pathway (CP) are well-documented in association with systemic lupus erythematosus (SLE) or SLE-like syndromes and severe pyogenic infections.
Jessica S. Kleer +9 more
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Complement C1s as a diagnostic marker and therapeutic target: Progress and propective [PDF]
Frontiers in Immunology, 2022 The molecules of the complement system connect the effectors of innate and adaptive immunity and play critical roles in maintaining homeostasis. Among them, the C1 complex, composed of C1q, C1r, and C1s (C1qr2s2), is the initiator of the classical ...
Jun Ye +4 more
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HMGB1 cleavage by complement C1s and its potent anti-inflammatory product [PDF]
Frontiers in Immunology, 2023 Complement C1s association with the pathogenesis of several diseases cannot be simply explained only by considering its main role in activating the classical complement pathway.
Marie Lorvellec +11 more
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Quantitative fluorescence resonance energy transfer-based immunoassay for activated complement C1s [PDF]
Frontiers in Immunology, 2023 ObjectivesC1s activation is associated with the pathogenesis of various diseases, indicating the potential value of C1s activation detection in clinic.
Jun Ye +5 more
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The expression and biological role of complement C1s in esophageal squamous cell carcinoma [PDF]
Open Life SciencesThe present work focused on investigating the role of the altered expression of complement C1s in proliferation and apoptosis of esophageal squamous cell carcinoma (ESCC) cells and explore its biological functions in ESCC, so as to lay a theoretical ...
Ge Ruomu +5 more
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C1s protects cutaneous squamous carcinoma cells from TRAIL-induced apoptosis [PDF]
OncogenesisCutaneous squamous cell carcinoma (cSCC) is the most common metastatic skin cancer. The prognosis of the metastatic cSCC is poor, and there are no established biomarkers to predict metastasis risk, nor specific targeted therapies for advanced or ...
Maria Salmela +7 more
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C1 Complex: An Adaptable Proteolytic Module for Complement and Non-Complement Functions [PDF]
Frontiers in Immunology, 2017 Complement C1 is the defining component of the classical pathway. Within the C1qC1r2C1s2 complex, C1q functions as a molecular scaffold for C1r2C1s2 and C1q binding to its ligands activates these two serine proteases.
Jinhua Lu, Uday Kishore
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Long lasting complement neutralisation by RAY121, an engineered anti-C1s antibody with C1q displacement functionResearch in context [PDF]
EBioMedicineSummary: Background: Antibody drugs blocking the complement classical pathway (CP) often require frequent intravenous administration to overcome the high abundance or rapid turnover of complement proteins.
Adrian W.S. Ho +27 more
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Alzheimer’s disease-associated complement gene variants influence plasma complement protein levels
Journal of Neuroinflammation, 2023 Background Alzheimer’s disease (AD) has been associated with immune dysregulation in biomarker and genome-wide association studies (GWAS). GWAS hits include the genes encoding complement regulators clusterin (CLU) and complement receptor 1 (CR1 ...
Aurora Veteleanu +11 more
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Degradation of collagen I by activated C1s in periodontal Ehlers-Danlos Syndrome
Frontiers in Immunology, 2023 Periodontal Ehlers-Danlos syndrome (pEDS) is an autosomal dominant disorder characterized by early-onset periodontitis leading to premature loss of teeth, lack of attached gingiva and thin and fragile gums leading to gingival recession. Connective tissue
Albert Amberger +8 more
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